adisease

Showing entry for Liver Failure

General Disease Information
BXGD Id	BXGD003200
Disease Name	Liver Failure
Disease CUI Id	C0085605
MeSH Codes	C06
Disease Class Name	Digestive System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0025031
Human Phenotype Ontology Term	Abnormality of the digestive system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00142	BXGT003883	Thymidine kinase 2, mitochondrial	7084	reviewed	Kinase
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15111	BXGT004126	Inhibitor of nuclear factor kappa-B kinase subunit alpha	1147	reviewed	Kinase
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O15120	BXGT004129	1-acyl-sn-glycerol-3-phosphate acyltransferase beta	10555	reviewed
O43181	BXGT004576	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	4724	reviewed
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43660	BXGT004609	Pleiotropic regulator 1	5356	reviewed
O43708	BXGT004617	Maleylacetoacetate isomerase	2954	reviewed
O43772	BXGT004623	Mitochondrial carnitine/acylcarnitine carrier protein	788	reviewed	Transporter
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75880	BXGT005158	Protein SCO1 homolog, mitochondrial	6341	reviewed	Enzyme
O95150	BXGT005351	Tumor necrosis factor ligand superfamily member 15	9966	reviewed	Signaling
O95278	BXGT005370	Laforin	7957	reviewed
O95342	BXGT005373	Bile salt export pump	8647	reviewed	Transporter
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00480	BXGT005551	Ornithine carbamoyltransferase, mitochondrial	5009	reviewed
P00488	BXGT005552	Coagulation factor XIII A chain	2162	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00846	BXGT005674	ATP synthase subunit a	4508	reviewed	Transporter
P00966	BXGT005707	Argininosuccinate synthase	445	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02763	BXGT005951	Alpha-1-acid glycoprotein 1	5004	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03886	BXGT006108	NADH-ubiquinone oxidoreductase chain 1	4535	reviewed	Enzyme
P03891	BXGT006110	NADH-ubiquinone oxidoreductase chain 2	4536	reviewed
P03897	BXGT006111	NADH-ubiquinone oxidoreductase chain 3	4537	reviewed
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P03915	BXGT006114	NADH-ubiquinone oxidoreductase chain 5	4540	reviewed	Enzyme
P03923	BXGT006115	NADH-ubiquinone oxidoreductase chain 6	4541	reviewed
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04424	BXGT006214	Argininosuccinate lyase	435	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05160	BXGT006330	Coagulation factor XIII B chain	2165	reviewed
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05181	BXGT006337	Cytochrome P450 2E1	1571	reviewed
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05787	BXGT006385	Keratin, type II cytoskeletal 8	3856	reviewed
P06276	BXGT006430	Cholinesterase	590	reviewed
P07902	BXGT006697	Galactose-1-phosphate uridylyltransferase	2592	reviewed	Enzyme
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	3309	reviewed
P11678	BXGT007736	Eosinophil peroxidase	8288	reviewed	Enzyme
P13236	BXGT007891	C-C motif chemokine 4	6351	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13612	BXGT007928	Integrin alpha-4	3676	reviewed
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14550	BXGT008019	Aldo-keto reductase family 1 member A1	10327	reviewed	Enzyme
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16930	BXGT008272	Fumarylacetoacetase	2184	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	5770	reviewed
P21266	BXGT008632	Glutathione S-transferase Mu 3	2947	reviewed
P21439	BXGT008649	Phosphatidylcholine translocator ABCB4	5244	reviewed	Transporter
P22087	BXGT008729	rRNA 2'-O-methyltransferase fibrillarin	2091	reviewed	Enzyme
P22455	BXGT008772	Fibroblast growth factor receptor 4	2264	reviewed	Kinase
P22830	BXGT008809	Ferrochelatase, mitochondrial	2235	reviewed	Enzyme
P23381	BXGT008860	Tryptophan--tRNA ligase, cytoplasmic	7453	reviewed	Enzyme
P23526	BXGT008878	Adenosylhomocysteinase	191	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23786	BXGT008906	Carnitine O-palmitoyltransferase 2, mitochondrial	1376	reviewed	Enzyme
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31327	BXGT009523	Carbamoyl-phosphate synthase [ammonia], mitochondrial	1373	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P34931	BXGT009771	Heat shock 70 kDa protein 1-like	3305	reviewed
P34949	BXGT009775	Mannose-6-phosphate isomerase	4351	reviewed	Enzyme
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35398	BXGT009825	Nuclear receptor ROR-alpha	6095	reviewed	Nuclear receptor
P35498	BXGT009838	Sodium channel protein type 1 subunit alpha	6323	reviewed	Ion channel
P35558	BXGT009847	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	5105	reviewed	Kinase
P37023	BXGT009953	Serine/threonine-protein kinase receptor R3	94	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38571	BXGT010054	Lysosomal acid lipase/cholesteryl ester hydrolase	3988	reviewed	Enzyme
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46781	BXGT010539	40S ribosomal protein S9	6203	reviewed	Nucleic acid binding
P46934	BXGT010553	E3 ubiquitin-protein ligase NEDD4	4734	reviewed	Enzyme
P47712	BXGT010577	Cytosolic phospholipase A2	5321	reviewed	Enzyme
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48065	BXGT010617	Sodium- and chloride-dependent betaine transporter	6539	reviewed	Transporter
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P50416	BXGT010797	Carnitine O-palmitoyltransferase 1, liver isoform	1374	reviewed	Enzyme
P50542	BXGT010808	Peroxisomal targeting signal 1 receptor	5830	reviewed	Transporter
P51787	BXGT010889	Potassium voltage-gated channel subfamily KQT member 1	3784	reviewed	Ion channel
P51857	BXGT010899	Aldo-keto reductase family 1 member D1	6718	reviewed	Enzyme
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P55789	BXGT011126	FAD-linked sulfhydryl oxidase ALR	2671	reviewed	Enzyme
P56192	BXGT011149	Methionine--tRNA ligase, cytoplasmic	4141	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62753	BXGT011454	40S ribosomal protein S6	6194	reviewed	Nucleic acid binding
P78504	BXGT011844	Protein jagged-1	182	reviewed
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
Q00059	BXGT012512	Transcription factor A, mitochondrial	7019	reviewed
Q04446	BXGT012764	1,4-alpha-glucan-branching enzyme	2632	reviewed	Enzyme
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q5T6L4	BXGT015848	Argininosuccinate synthase 1 isoform 1	445	unreviewed
Q6P589	BXGT016452	Tumor necrosis factor alpha-induced protein 8-like protein 2	79626	reviewed
Q8TDU6	BXGT018814	G-protein coupled bile acid receptor 1	151306	reviewed	G-protein coupled receptor
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q9BQ65	BXGT020107	U6 snRNA phosphodiesterase	79650	reviewed
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9HBE5	BXGT020518	Interleukin-21 receptor	50615	reviewed	Receptor
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9UER7	BXGT021672	Death domain-associated protein 6	1616	reviewed
Q9UGM6	BXGT021687	Tryptophan--tRNA ligase, mitochondrial	10352	reviewed
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y572	BXGT022289	Receptor-interacting serine/threonine-protein kinase 3	11035	reviewed	Kinase
Q9Y5L0	BXGT022296	Transportin-3	23534	reviewed	Transporter
Q9Y619	BXGT022316	Mitochondrial ornithine transporter 1	10166	reviewed	Transporter
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
P09622	BXGT023116	Dihydrolipoyl dehydrogenase, mitochondrial	1738	reviewed	Enzyme
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P35670	BXGT023695	Copper-transporting ATPase 2	540	reviewed	Transporter
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
P61916	BXGT025881	NPC intracellular cholesterol transporter 2	10577	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}