Showing entry for Guanylyl cyclase-activating protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010354
Protein NameGuanylyl cyclase-activating protein 1
Uniport IdP43080
GeneGUCA1A
Gene Id2978
DomainEF-hand_7
Pfam PF13499  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.7 Sensory system hsa04744 Phototransduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0007602 phototransduction
Biological Process GO:0010753 positive regulation of cGMP-mediated signaling
Biological Process GO:0031284 positive regulation of guanylate cyclase activity
Biological Process GO:0022400 regulation of rhodopsin mediated signaling pathway
Biological Process GO:0007165 signal transduction
Biological Process GO:0007601 visual perception
molecular function GO:0005509 calcium ion binding
molecular function GO:0008048 calcium sensitive guanylate cyclase activator activity
molecular function GO:0030249 guanylate cyclase regulator activity
cellular component GO:0120199 cone photoreceptor outer segment
cellular component GO:0097381 photoreceptor disc membrane
cellular component GO:0001917 photoreceptor inner segment
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-2187338 Visual phototransduction
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009398 BXGD000604 Color vision defect Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0162666 BXGD003967 Mitochondrial Encephalomyopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0271092 BXGD006161 Progressive cone dystrophy (without rod involvement) Eye Diseases
C0271097 BXGD006163 Usher Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0339508 BXGD007256 Hereditary macular dystrophy
C0339510 BXGD007257 Vitelliform Macular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0410000 BXGD008406 Overlap syndrome Skin and Connective Tissue Diseases; Immune System Diseases
C0423421 BXGD008484 Atrophic macular change
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0543968 BXGD009303 Cone dysfunction syndrome
C0730290 BXGD009946 Cone Dystrophy Eye Diseases
C0730292 BXGD009947 Macular dystrophy Eye Diseases
C0730362 BXGD009961 Disorder of macula of retina Eye Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0858618 BXGD011184 Dyschromatopsia
C1260959 BXGD011846 Drusen
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1536451 BXGD013344 Central areolar choroidal sclerosis Eye Diseases
C1839364 BXGD014371 Progressive visual loss
C1849394 BXGD015048 Enhanced S-Cone Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1852548 BXGD015291 Absent retinal pigment epithelium
C1853141 BXGD015307 Slow decrease in visual acuity
C1854065 BXGD015379 LATE-ONSET RETINAL DEGENERATION (disorder) Eye Diseases
C1857644 BXGD015728 Retinal pigment epithelial mottling
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1865869 BXGD016347 CONE DYSTROPHY 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1867326 BXGD016447 RETINAL CONE DYSTROPHY 1 Eye Diseases
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2733564 BXGD017563 Full thickness hole of macula lutea Eye Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C3275758 BXGD018675 Choriocapillaris atrophy
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3665342 BXGD019277 Progressive Cone Dystrophy Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3669212 BXGD019325 Progressive retinal atrophy
C4073085 BXGD022036 Foveal photoreceptor outer segment loss on macular OCT
C4073099 BXGD022037 Perifoveal ring of hyperautofluorescence
C4073101 BXGD022038 Hyperautofluorescent macular lesion
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002144 Tetradecanoic acid 228.37
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein