Showing entry for Peregrin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011109
Protein NamePeregrin
Uniport IdP55201
GeneBRPF1
Gene Id7862
DomainBromodomain; EPL1; PHD_2; PWWP; zf-HC5HC2H_2
Pfam PF00439   PF10513   PF00855  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043966 histone H3 acetylation
Biological Process GO:0044154 histone H3-K14 acetylation
Biological Process GO:0043972 histone H3-K23 acetylation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
molecular function GO:0003677 DNA binding
molecular function GO:0042393 histone binding
molecular function GO:0046872 metal ion binding
cellular component GO:0005694 chromosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000123 histone acetyltransferase complex
cellular component GO:0070776 MOZ/MORF histone acetyltransferase complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-4839726 Chromatin organization
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005744 BXGD000330 Blepharophimosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009363 BXGD000599 Congenital ocular coloboma (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0221369 BXGD004453 Acquired Camptodactyly
C0232466 BXGD004543 Feeding difficulties
C0239479 BXGD004982 Round face
C0241726 BXGD005110 Delayed ability to walk
C0264306 BXGD005380 Laryngeal Obstruction Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0376175 BXGD007981 Bell Palsy Infections; Nervous System Diseases; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0432072 BXGD008718 Dysmorphic features
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0857379 BXGD011148 Abnormality of the pinna
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836542 BXGD014129 Depressed nasal bridge
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1843367 BXGD014576 Poor school performance
C1849089 BXGD015004 Broad forehead
C1849265 BXGD015028 Overgrowth
C1849367 BXGD015046 Nasal bridge wide
C1853241 BXGD015321 Flat face
C1857479 BXGD015705 Short columella
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861324 BXGD016029 Short philtrum
C1861403 BXGD016045 Variable expressivity
C1865014 BXGD016282 Long philtrum
C1865244 BXGD016301 Shallow orbits Eye Diseases
C1866195 BXGD016385 Downturned corners of mouth
C2673410 BXGD017200 Small midface
C3163801 BXGD018517 Abnormality of aortic arch
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4310617 BXGD022599 INTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND PTOSIS
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0002722 Nitrate 62
BXGC0003705 Chloride 35.45
BXGC0005169 4-Phenylpyridine 155.2
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein