Showing entry for Ras-related protein Rab-8A


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011345
Protein NameRas-related protein Rab-8A
Uniport IdP61006
GeneRAB8A
Gene Id4218
DomainRas
Pfam PF00071  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006914 autophagy
Biological Process GO:0007409 axonogenesis
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0060271 cilium assembly
Biological Process GO:0048210 Golgi vesicle fusion to target membrane
Biological Process GO:0098969 neurotransmitter receptor transport to postsynaptic membrane
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0009306 protein secretion
Biological Process GO:0010506 regulation of autophagy
Biological Process GO:0017157 regulation of exocytosis
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:0051223 regulation of protein transport
Biological Process GO:0006904 vesicle docking involved in exocytosis
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0031489 myosin V binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0017137 Rab GTPase binding
cellular component GO:0005814 centriole
cellular component GO:0005813 centrosome
cellular component GO:0036064 ciliary basal body
cellular component GO:0097546 ciliary base
cellular component GO:0005929 cilium
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0005768 endosome
cellular component GO:0070062 extracellular exosome
cellular component GO:0000139 Golgi membrane
cellular component GO:0030496 midbody
cellular component GO:0043025 neuronal cell body
cellular component GO:0097730 non-motile cilium
cellular component GO:0045335 phagocytic vesicle
cellular component GO:0030670 phagocytic vesicle membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0055038 recycling endosome membrane
cellular component GO:0008021 synaptic vesicle
cellular component GO:0032588 trans-Golgi network membrane
cellular component GO:0030140 trans-Golgi network transport vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1640170 Cell Cycle
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-199991 Membrane Trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-392499 Metabolism of proteins
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620916 VxPx cargo-targeting to cilium
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-597592 Post-translational protein modification
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-9007101 Rab regulation of trafficking
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004565 BXGD000276 Melanoma, B16 Neoplasms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020490 BXGD001403 Hyperopia Eye Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026847 BXGD001940 Spinal Muscular Atrophy Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0341306 BXGD007401 Microvillus inclusion disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0521585 BXGD009145 Gastrointestinal mucositis Digestive System Diseases; Stomatognathic Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0752166 BXGD010684 Bardet-Biedl Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1837148 BXGD014202 MYOPIA 6 (disorder) Eye Diseases
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1998028 BXGD016865 Photoreceptor degeneration Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C2745900 BXGD017568 Promyelocytic leukemia
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2939461 BXGD018180 Myeloid neoplasm Neoplasms; Hemic and Lymphatic Diseases
C3714514 BXGD019409 Infection Infections
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4725861 BXGD023840 Metastatic Malignant Neoplasm in the Viscera
C4727838 BXGD023874 Advanced Melanoma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein