Showing entry for Histone H3.3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012052
Protein NameHistone H3.3
Uniport IdP84243
GeneH3-3A
Gene Id3020;3021
DomainHistone
Pfam PF00125  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0007420 brain development
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0006336 DNA replication-independent nucleosome assembly
Biological Process GO:0007566 embryo implantation
Biological Process GO:0008584 male gonad development
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0042692 muscle cell differentiation
Biological Process GO:1902340 negative regulation of chromosome condensation
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0006997 nucleus organization
Biological Process GO:0048477 oogenesis
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0031508 pericentric heterochromatin assembly
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0000183 rDNA heterochromatin assembly
Biological Process GO:0090230 regulation of centromere complex assembly
Biological Process GO:0060964 regulation of gene silencing by miRNA
Biological Process GO:0045652 regulation of megakaryocyte differentiation
Biological Process GO:0009725 response to hormone
Biological Process GO:0007338 single fertilization
Biological Process GO:0007286 spermatid development
Biological Process GO:0031509 subtelomeric heterochromatin assembly
Biological Process GO:0032200 telomere organization
molecular function GO:0031492 nucleosomal DNA binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
cellular component GO:0001740 Barr body
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0000228 nuclear chromosome
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0000788 nuclear nucleosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0000786 nucleosome
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology
R-HSA-1474165 Reproduction
R-HSA-1500620 Meiosis
R-HSA-157118 Signaling by NOTCH
R-HSA-157579 Telomere Maintenance
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-1912422 Pre-NOTCH Expression and Processing
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-211000 Gene Silencing by RNA
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559583 Cellular Senescence
R-HSA-392499 Metabolism of proteins
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-73728 RNA Polymerase I Promoter Opening
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-73886 Chromosome Maintenance
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-8939211 ESR-mediated signaling
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-912446 Meiotic recombination
R-HSA-9616222 Transcriptional regulation of granulopoiesis
R-HSA-9670095 Inhibition of DNA recombination at telomere
R-HSA-977225 Amyloid fiber formation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0008441 BXGD000540 Chondroblastoma Neoplasms
C0008476 BXGD000543 Chondromatosis, Synovial Musculoskeletal Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017525 BXGD001112 Giant Cell Tumors Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0029405 BXGD002136 Osteitis Fibrosa Cystica Musculoskeletal Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029427 BXGD002144 Synovial osteochondromatosis Musculoskeletal Diseases
C0029441 BXGD002150 Osteoid osteoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0085136 BXGD003131 Central Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206637 BXGD004202 Mesenchymal Chondrosarcoma Neoplasms
C0206638 BXGD004203 Giant Cell Tumor of Bone Neoplasms
C0206715 BXGD004261 Neoplasms, Neuroepithelial Neoplasms
C0206726 BXGD004271 gliosarcoma Neoplasms
C0220603 BXGD004293 Childhood Brain Neoplasm Neoplasms; Nervous System Diseases
C0220620 BXGD004299 Gastrointestinal Carcinoid Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0221290 BXGD004439 Chondromyxoid fibroma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0280483 BXGD006750 Adult Anaplastic Astrocytoma Neoplasms
C0334552 BXGD007109 Malignant Giant Cell Tumor of Bone Neoplasms; Musculoskeletal Diseases
C0334553 BXGD007110 Giant Cell Tumor of Soft Tissue Neoplasms
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0334586 BXGD007126 Pleomorphic Xanthoastrocytoma Neoplasms
C0427460 BXGD008616 Red cell distribution width determination
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1266167 BXGD011985 Chondrosarcoma, Clear Cell Neoplasms
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332610 BXGD012538 Brain Stem Glioblastoma
C1332982 BXGD012572 Childhood Mesenchymal Chondrosarcoma Neoplasms
C1334008 BXGD012675 High Grade Sarcoma
C1541317 BXGD013351 Adult Gliosarcoma Neoplasms
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704327 BXGD013546 Bone Sarcoma Neoplasms; Musculoskeletal Diseases
C1845055 BXGD014705 ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1997217 BXGD016859 Low grade glioma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C3899645 BXGD020087 Childhood Pleomorphic Xanthoastrocytoma
C3899658 BXGD020092 Childhood Gliosarcoma Neoplasms
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4283858 BXGD022426 Anaplastic Pleomorphic Xanthoastrocytoma Neoplasms
C4289580 BXGD022491 Epithelioid glioblastoma
C4551548 BXGD023342 Grade III Childhood Astrocytoma Neoplasms
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722099 BXGD023789 High grade glioma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0004275 Acetaldehyde 44.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein