Showing entry for Transducin-like enhancer protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012778
Protein NameTransducin-like enhancer protein 1
Uniport IdQ04724
GeneTLE1
Gene Id7088
DomainTLE_N; WD40
Pfam PF03920   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:1904837 beta-catenin-TCF complex assembly
Biological Process GO:0007275 multicellular organism development
Biological Process GO:2000811 negative regulation of anoikis
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0030178 negative regulation of Wnt signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0007165 signal transduction
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0042802 identical protein binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0003714 transcription corepressor activity
molecular function GO:0008134 transcription factor binding
cellular component GO:1990907 beta-catenin-TCF complex
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-1980143 Signaling by NOTCH1
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-4641265 Repression of WNT target genes
R-HSA-4641265 Repression of WNT target genes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017653 BXGD001135 Glomus Tumor Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027070 BXGD001967 Myoepithelioma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037579 BXGD002694 Soft Tissue Neoplasms Neoplasms
C0039101 BXGD002790 synovial sarcoma Neoplasms
C0042029 BXGD002951 Urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205641 BXGD004093 Adenocarcinoma, Basal Cell Neoplasms
C0205646 BXGD004098 Adenoma, Basal Cell Neoplasms
C0206647 BXGD004212 Dermatofibrosarcoma Neoplasms
C0206743 BXGD004285 Rhabdoid Tumor Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262584 BXGD005256 Carcinoma, Small Cell Neoplasms
C0278622 BXGD006551 Adult Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0278660 BXGD006555 Adult Synovial Sarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279982 BXGD006702 Childhood Synovial Sarcoma Neoplasms
C0279987 BXGD006706 Childhood Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349637 BXGD007942 Common acute lymphoblastic leukemia
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0392784 BXGD008069 Dermatofibrosarcoma Protuberans Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0751689 BXGD010552 Peripheral Nerve Sheath Neoplasm Neoplasms; Nervous System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0855070 BXGD011066 Synovial sarcoma metastatic Neoplasms
C0861353 BXGD011247 Noninvasive ductal carcinoma
C1176475 BXGD011798 Ductal Carcinoma Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1266025 BXGD011935 Traditional Serrated Adenoma Neoplasms
C1266127 BXGD011968 Histiocytoma, Angiomatoid Fibrous Neoplasms
C1266184 BXGD011991 Atypical Teratoid Rhabdoid Tumor Neoplasms
C1275210 BXGD012066 Sebaceoma
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1368816 BXGD012902 Sebaceous adenoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1527349 BXGD013277 Ductal Breast Carcinoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2243086 BXGD017010 basal cell adenocarcinoma of salivary gland Neoplasms
C2347613 BXGD017039 Childhood Atypical Teratoid/Rhabdoid Tumor
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3693482 BXGD019337 Giant Cell Fibroblastoma Neoplasms
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein