Showing entry for Neuronal acetylcholine receptor subunit alpha-7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012847
Protein NameNeuronal acetylcholine receptor subunit alpha-7
Uniport IdQ05941
GeneChrna7
Gene Id25302
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0095500 acetylcholine receptor signaling pathway
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0008306 associative learning
Biological Process GO:0042113 B cell activation
Biological Process GO:0048149 behavioral response to ethanol
Biological Process GO:0035095 behavioral response to nicotine
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050890 cognition
Biological Process GO:0140059 dendrite arborization
Biological Process GO:0097061 dendritic spine organization
Biological Process GO:0042416 dopamine biosynthetic process
Biological Process GO:0006897 endocytosis
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0060112 generation of ovulation cycle rhythm
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0007611 learning or memory
Biological Process GO:0007613 memory
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0098815 modulation of excitatory postsynaptic potential
Biological Process GO:1902430 negative regulation of amyloid-beta formation
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0032715 negative regulation of interleukin-6 production
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0032720 negative regulation of tumor necrosis factor production
Biological Process GO:0050877 nervous system process
Biological Process GO:0019228 neuronal action potential
Biological Process GO:0042698 ovulation cycle
Biological Process GO:1902004 positive regulation of amyloid-beta formation
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:1905920 positive regulation of CoA-transferase activity
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0001988 positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:0033138 positive regulation of peptidyl-serine phosphorylation
Biological Process GO:0051247 positive regulation of protein metabolic process
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:1905906 regulation of amyloid fibril formation
Biological Process GO:1902991 regulation of amyloid precursor protein catabolic process
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:1901214 regulation of neuron death
Biological Process GO:0014061 regulation of norepinephrine secretion
Biological Process GO:0032225 regulation of synaptic transmission, dopaminergic
Biological Process GO:1905144 response to acetylcholine
Biological Process GO:1904645 response to amyloid-beta
Biological Process GO:0009409 response to cold
Biological Process GO:0045471 response to ethanol
Biological Process GO:0032094 response to food
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0035094 response to nicotine
Biological Process GO:0050893 sensory processing
Biological Process GO:0007165 signal transduction
Biological Process GO:0050808 synapse organization
Biological Process GO:0007271 synaptic transmission, cholinergic
Biological Process GO:0042110 T cell activation
molecular function GO:0042166 acetylcholine binding
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0008179 adenylate cyclase binding
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0051117 ATPase binding
molecular function GO:0017081 chloride channel regulator activity
molecular function GO:0008144 drug binding
molecular function GO:0005216 ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0015643 toxic substance binding
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0016324 apical plasma membrane
cellular component GO:0032279 asymmetric synapse
cellular component GO:0030673 axolemma
cellular component GO:0030424 axon
cellular component GO:0098981 cholinergic synapse
cellular component GO:0005737 cytoplasm
cellular component GO:0030425 dendrite
cellular component GO:0043198 dendritic shaft
cellular component GO:0043197 dendritic spine
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0030426 growth cone
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0099065 integral component of spine apparatus membrane
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0044853 plasma membrane raft
cellular component GO:0014069 postsynaptic density
cellular component GO:0042734 presynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000409 Choline 104.17
BXGC0000555 3-Ethylpyridine 107.15
BXGC0001488 Erysodine 299.36
BXGC0001518 (S)-2-Propylpiperidine 127.23
BXGC0001589 Arecoline 155.19
BXGC0002796 Nicotine 162.23
BXGC0002987 2,6-Diemthyl-pyridine 107.15
BXGC0002989 2-Ethylpyridine 107.15
BXGC0002992 2-Methylpyridine 93.13
BXGC0003004 3-Methylpyridine 93.13
BXGC0003010 4-Methylpyridine 93.13
BXGC0003102 Acetylcholine 146.21
BXGC0003128 Cotinine 176.22
BXGC0003965 Prolamine 71.12
BXGC0006243 Piperidine 85.15
BXGC0007675 Pyridine 79.1
BXGC0017878 lappaconitine 584.31
BXGC0019419 2-hydroxypyridine 95.04
BXGC0021495 Dl-Anabasine 162.12
BXGC0021636 2-[(2R,6S)-1-Methyl-6-Phenacylpiperidin-2-Yl]-1-Phenylethanone 335.19
BXGC0021656 Lycoctonine 467.29
BXGC0026677 4-methylpiperidine 99.1
BXGC0027349 Lycoctonine 467.29
BXGC0033981 Cyfusine 176.09
BXGC0035415 R-Nicotine 162.12
BXGC0035631 cytisine 190.11
BXGC0035635 Karakoline 377.26
BXGC0038169 (-)-Lobeline 337.2
BXGC0042104 Trimethyl(2-Phenoxyethyl)Azanium 180.14
BXGC0042179 Atropine 289.17
BXGC0046653 (+/-)Nicotine 162.12
BXGC0049005 (1R)-2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-Phenylethyl]-1-Methylpiperidin-2-Yl]-1-Phenylethanol 339.22
BXGC0050754 Cytisine 190.11
BXGC0052646 Tubocurarine 609.3
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein