acompound

Showing entry for Cytisine

General Compound Information
BXGC Id	BXGC0050754
Compound Name	Cytisine
Structure
Formula	C11H14N2O
InchiKey	ANJTVLIZGCUXLD-DTWKUNHWSA-N
SMILES	O=c1cccc2n1C[C@@H]1CNC[C@H]2C1
Inchi	InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1
IUPAC
Molecular Weight	190.11
Pubchem Id	10235
Chembl Id	CHEMBL497939

Targets of Information Source

DrugBank

DB09028

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	experimental	agonist
P36544	BXGT009926	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	CHRNA7	experimental	agonist
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	experimental	agonist
Q15825	BXGT013603	Neuronal acetylcholine receptor subunit alpha-6	reviewed	Ion channel	CHRNA6	experimental	agonist
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	experimental	partial agonist

PDB

C5E

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Q8WSF8	BXGT018982	Soluble acetylcholine receptor	unreviewed		-	-	-	-	-

Binding DB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM

CHEMBL

CHEMBL497939

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Ki	'='	0	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Ki	'='	0	nM
Q07001	BXGT012907	Acetylcholine receptor subunit delta	reviewed	Ion channel	CHRND	Ki	'='	250	nM
P11230	BXGT007677	Acetylcholine receptor subunit beta	reviewed	Ion channel	CHRNB1	Ki	'='	250	nM
P07510	BXGT006631	Acetylcholine receptor subunit gamma	reviewed	Ion channel	CHRNG	Ki	'='	250	nM
P02708	BXGT005927	Acetylcholine receptor subunit alpha	reviewed	Ion channel	CHRNA1	Ki	'='	250	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Rmax	'='	42	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Rmax	'='	42	%
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Efficacy	'='	6	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Efficacy	'='	6	%
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Rmax	'='	55	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Rmax	'='	55	%
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	EC50	'='	67000	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	EC50	'='	67000	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Rmax	'='	90	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	90	%
P97697	BXGT012214	Inositol monophosphatase 1	reviewed	-	Impa1	Potency	'='	3162	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Rmax	'='	23	uM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Rmax	'='	23	uM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Rmax	'='	105	%
P36544	BXGT009926	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	CHRNA7	EC50	'='	71000	nM
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	2	%
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	2	nM
P20420	BXGT008572	Neuronal acetylcholine receptor subunit alpha-5	reviewed	-	Chrna5	Ki	'='	2	nM
P43143	BXGT010361	Neuronal acetylcholine receptor subunit alpha-6	reviewed	-	Chrna6	Ki	'='	2	nM
P12391	BXGT007811	Neuronal acetylcholine receptor subunit beta-3	reviewed	-	Chrnb3	Ki	'='	2	nM
Q9JLB5	BXGT020832	Neuronal acetylcholine receptor subunit alpha-10	reviewed	-	Chrna10	Ki	'='	2	nM
P43144	BXGT010362	Neuronal acetylcholine receptor subunit alpha-9	reviewed	-	Chrna9	Ki	'='	2	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	2	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	2	nM
P12389	BXGT007809	Neuronal acetylcholine receptor subunit alpha-2	reviewed	-	Chrna2	Ki	'='	2	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	2	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Ki	'='	2	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	4	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	4	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	EC50	'='	8	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	EC50	'='	8	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Affinity	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Affinity	'='	0	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Ki	'='	1560	nM
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Ki	'='	1560	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	0	nM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	AC50	-	-	-
P02710	BXGT005928	Acetylcholine receptor subunit alpha	reviewed	-	CHRNA1	Activity	-	-	-
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	1	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Affinity	'='	220	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Affinity	'='	220	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	EC50	'='	0	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	EC50	'='	0	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	-	-	-
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	5820	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	-3	%
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Efficacy	'='	62	%
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Efficacy	'='	62	%
Q9NPD5	BXGT021151	Solute carrier organic anion transporter family member 1B3	reviewed	Transporter	SLCO1B3	Inhibition	'='	106	%
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	0	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P12389	BXGT007809	Neuronal acetylcholine receptor subunit alpha-2	reviewed	-	Chrna2	Ki	'='	1	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Rmax	'='	56	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	56	%
P04062	BXGT006140	Lysosomal acid glucosylceramidase	reviewed	-	GBA	Potency	-	17782	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Potency	'='	31622	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Rmax	'='	11	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Rmax	'='	11	%
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	IC50	'='	50	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	IC50	'='	50	nM
Q07001	BXGT012907	Acetylcholine receptor subunit delta	reviewed	Ion channel	CHRND	Efficacy	'='	55	%
P11230	BXGT007677	Acetylcholine receptor subunit beta	reviewed	Ion channel	CHRNB1	Efficacy	'='	55	%
P07510	BXGT006631	Acetylcholine receptor subunit gamma	reviewed	Ion channel	CHRNG	Efficacy	'='	55	%
P02708	BXGT005927	Acetylcholine receptor subunit alpha	reviewed	Ion channel	CHRNA1	Efficacy	'='	55	%
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	0	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Response	'='	56	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Response	'='	56	%
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	-	-	-
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	'='	31622	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	-	-	-
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	EC50	-	-	-
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	EC50	-	-	-
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	8	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	8	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	37	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Ki	'='	37	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	0	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	331	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Ki	'='	840	nM
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Ki	'='	840	nM
P36544	BXGT009926	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	CHRNA7	Ki	'='	1420	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Inhibition	'='	30	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Inhibition	'='	30	%
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	1	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	37	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Ki	'='	37	nM
Q15822	BXGT013602	Neuronal acetylcholine receptor subunit alpha-2	reviewed	Ion channel	CHRNA2	Rmax	'='	58	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	58	%
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Rmax	'='	2	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Rmax	'='	2	%
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	4200	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	2	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	2	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	1000	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Rmax	'='	90	%
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	300	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	261	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	-	-	-
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	0	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	217	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Ki	'='	217	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P12389	BXGT007809	Neuronal acetylcholine receptor subunit alpha-2	reviewed	-	Chrna2	Ki	'='	1	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	2	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	2	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	14125	nM
P02718	BXGT005931	Acetylcholine receptor subunit delta	reviewed	-	chrnd	EC50	'='	100000	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Rmax	'='	77	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	77	%
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	EC50	'='	25	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	EC50	'='	25	nM
Q07001	BXGT012907	Acetylcholine receptor subunit delta	reviewed	Ion channel	CHRND	Ki	-	-	-
P11230	BXGT007677	Acetylcholine receptor subunit beta	reviewed	Ion channel	CHRNB1	Ki	-	-	-
P07510	BXGT006631	Acetylcholine receptor subunit gamma	reviewed	Ion channel	CHRNG	Ki	-	-	-
P02708	BXGT005927	Acetylcholine receptor subunit alpha	reviewed	Ion channel	CHRNA1	Ki	-	-	-
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	EC50	'='	26000	nM
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	EC50	'='	26000	nM
P02545	BXGT005889	Prelamin-A/C	reviewed	-	LMNA	Potency	'='	63	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	210	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Ki	'='	210	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Rmax	'='	51	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	51	%
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Rmax	'='	70	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	70	%
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Rmax	'='	89	%
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Rmax	'='	89	%
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Ki	'='	2	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Ki	'='	2	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	203	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	Ki	'='	203	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	0	nM
Q07001	BXGT012907	Acetylcholine receptor subunit delta	reviewed	Ion channel	CHRND	EC50	'='	11	nM
P11230	BXGT007677	Acetylcholine receptor subunit beta	reviewed	Ion channel	CHRNB1	EC50	'='	11	nM
P07510	BXGT006631	Acetylcholine receptor subunit gamma	reviewed	Ion channel	CHRNG	EC50	'='	11	nM
P02708	BXGT005927	Acetylcholine receptor subunit alpha	reviewed	Ion channel	CHRNA1	EC50	'='	11	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	IC50	'='	69	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	IC50	'='	69	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	1	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	2	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	2	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	1	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	1	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Efficacy	'='	59	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Efficacy	'='	59	%
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	EC50	'='	38000	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	EC50	'='	38000	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	EC50	'='	10000	nM
P20420	BXGT008572	Neuronal acetylcholine receptor subunit alpha-5	reviewed	-	Chrna5	EC50	'='	10000	nM
P43143	BXGT010361	Neuronal acetylcholine receptor subunit alpha-6	reviewed	-	Chrna6	EC50	'='	10000	nM
P12391	BXGT007811	Neuronal acetylcholine receptor subunit beta-3	reviewed	-	Chrnb3	EC50	'='	10000	nM
Q9JLB5	BXGT020832	Neuronal acetylcholine receptor subunit alpha-10	reviewed	-	Chrna10	EC50	'='	10000	nM
P43144	BXGT010362	Neuronal acetylcholine receptor subunit alpha-9	reviewed	-	Chrna9	EC50	'='	10000	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	EC50	'='	10000	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	EC50	'='	10000	nM
P12389	BXGT007809	Neuronal acetylcholine receptor subunit alpha-2	reviewed	-	Chrna2	EC50	'='	10000	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	EC50	'='	10000	nM
P04757	BXGT006258	Neuronal acetylcholine receptor subunit alpha-3	reviewed	-	Chrna3	EC50	'='	10000	nM
P36544	BXGT009926	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	CHRNA7	Ki	'='	4200	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	1	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	1	nM
P12392	BXGT007812	Neuronal acetylcholine receptor subunit beta-4	reviewed	-	Chrnb4	Ki	'='	5	nM
P12389	BXGT007809	Neuronal acetylcholine receptor subunit alpha-2	reviewed	-	Chrna2	Ki	'='	5	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	22387	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	8000	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	'='	31622	nM
P02714	BXGT005930	Acetylcholine receptor subunit gamma	reviewed	-	CHRNG	Ki	'='	250	nM
P02718	BXGT005931	Acetylcholine receptor subunit delta	reviewed	-	chrnd	Ki	'='	250	nM
P02712	BXGT005929	Acetylcholine receptor subunit beta	reviewed	-	CHRNB1	Ki	'='	250	nM
P02710	BXGT005928	Acetylcholine receptor subunit alpha	reviewed	-	CHRNA1	Ki	'='	250	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Ki	'='	280	nM
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Ki	'='	280	nM
O94782	BXGT005332	Ubiquitin carboxyl-terminal hydrolase 1	reviewed	Enzyme	USP1	Potency	-	39810	nM
O94782	BXGT005332	Ubiquitin carboxyl-terminal hydrolase 1	reviewed	Enzyme	USP1	Potency	-	158489	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Ki	'='	525	nM
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Ki	'='	525	nM
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	reviewed	Transporter	SLCO1B1	Inhibition	'='	99	%
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	2	nM
P12390	BXGT007810	Neuronal acetylcholine receptor subunit beta-2	reviewed	-	Chrnb2	Ki	'='	0	nM
P09483	BXGT006896	Neuronal acetylcholine receptor subunit alpha-4	reviewed	-	Chrna4	Ki	'='	0	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	39810	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	39810	nM
P02710	BXGT005928	Acetylcholine receptor subunit alpha	reviewed	-	CHRNA1	IC50	'='	3530	nM
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	250	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Efficacy	'='	56	%
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Efficacy	'='	56	%
Q05941	BXGT012847	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	Chrna7	Ki	'='	230	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	IC50	'='	28000	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	IC50	'='	28000	nM
P32297	BXGT009616	Neuronal acetylcholine receptor subunit alpha-3	reviewed	Ion channel	CHRNA3	Ki	'='	480	nM
P30926	BXGT009482	Neuronal acetylcholine receptor subunit beta-4	reviewed	Ion channel	CHRNB4	Ki	'='	480	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	Ki	'='	2	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	Ki	'='	2	nM
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	reviewed	Ion channel	CHRNA4	EC50	'='	2000	nM
P17787	BXGT008341	Neuronal acetylcholine receptor subunit beta-2	reviewed	Ion channel	CHRNB2	EC50	'='	2000	nM
P36544	BXGT009926	Neuronal acetylcholine receptor subunit alpha-7	reviewed	-	CHRNA7	Ki	'='	5890	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	44668	nM
A9XFY4	BXGT001818	Nicotinic acetylcholine receptor alpha 5 subunit	unreviewed	-	nAChRalpha5	Ki	'='	1230	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00994	Piper dilatatum	Piper dilatatum	Medicinal Plant
BXGF01068	Inulanthera calva	Inulanthera calva	Others
BXGF01318	Nicotiana raimondii	Nicotiana raimondii	Others
BXGF02139	Scolopia chinensis	Scolopia chinensis	Others
BXGF02852	Sophora flavescens	Sophora flavescens	Medicinal Plant
BXGF04284	Heliotropium hirsutissimum	Heliotropium hirsutissimum	Others
BXGF05212	Trollius europaeus	Trollius europaeus	Medicinal Plant
BXGF05582	Amaranthus spinosus	Amaranthus spinosus	Medicinal Plant
BXGF06294	Arum maximum	Arum maximum	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}