Showing entry for Apoptosis-stimulating of p53 protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013384
Protein NameApoptosis-stimulating of p53 protein 2
Uniport IdQ13625
GeneTP53BP2
Gene Id7159
DomainAnk; Ank_3; SH3_1
Pfam PF12796   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:1900119 positive regulation of execution phase of apoptosis
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0007165 signal transduction
molecular function GO:0042802 identical protein binding
molecular function GO:0051059 NF-kappaB binding
molecular function GO:0002039 p53 binding
molecular function GO:0017124 SH3 domain binding
cellular component GO:0030054 cell junction
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-114452 Activation of BH3-only proteins
R-HSA-139915 Activation of PUMA and translocation to mitochondria
R-HSA-212436 Generic Transcription Pathway
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-5357801 Programmed Cell Death
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020217 BXGD001365 Hydatidiform Mole Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206692 BXGD004243 Carcinoma, Lobular Neoplasms; Skin and Connective Tissue Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242852 BXGD005197 Proliferative vitreoretinopathy Eye Diseases
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0339543 BXGD007267 Epiretinal Membrane Eye Diseases
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0478099 BXGD009014 Other deletions of part of a chromosome
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0940937 BXGD011490 precancerous lesions
C1135868 BXGD011700 Gestational Trophoblastic Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1334015 BXGD012677 High Grade Intraepithelial Neoplasia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675857 BXGD017310 Holoprosencephaly 10 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C2931618 BXGD018040 Gestational trophoblastic disease Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087504 BXGD022156 Peritoneal dissemination
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein