Showing entry for Kynureninase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013662
Protein NameKynureninase
Uniport IdQ16719
GeneKYNU
Gene Id8942
DomainAminotran_5
Pfam PF00266  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00380 Tryptophan metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034354 'de novo' NAD biosynthetic process from tryptophan
Biological Process GO:0007568 aging
Biological Process GO:0043420 anthranilate metabolic process
Biological Process GO:0097053 L-kynurenine catabolic process
Biological Process GO:0009435 NAD biosynthetic process
Biological Process GO:0019805 quinolinate biosynthetic process
Biological Process GO:0034341 response to interferon-gamma
Biological Process GO:0034516 response to vitamin B6
Biological Process GO:0006569 tryptophan catabolic process
Biological Process GO:0019442 tryptophan catabolic process to acetyl-CoA
Biological Process GO:0019441 tryptophan catabolic process to kynurenine
molecular function GO:0061981 3-hydroxykynureninase activity
molecular function GO:0030429 kynureninase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030170 pyridoxal phosphate binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-71240 Tryptophan catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001126 BXGD000025 Renal tubular acidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025295 BXGD001855 Meningitis, Pneumococcal Infections; Nervous System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038362 BXGD002749 Stomatitis Stomatognathic Diseases
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0151747 BXGD003471 Renal tubular disorder Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152101 BXGD003540 Hypoplastic Left Heart Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0220981 BXGD004348 Metabolic acidosis Nutritional and Metabolic Diseases
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239234 BXGD004974 Low set ears
C0265677 BXGD005564 Congenital hemivertebra Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266294 BXGD005644 Unilateral agenesis of kidney Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266295 BXGD005645 Congenital hypoplasia of kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268474 BXGD005958 Hydroxykynureninuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270715 BXGD006089 Degenerative Diseases, Central Nervous System Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0423109 BXGD008470 Upward slant of palpebral fissure
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0426790 BXGD008577 Narrow thorax
C0432152 BXGD008728 Thoracic hemivertebra
C0432163 BXGD008729 Defect of vertebral segmentation Musculoskeletal Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0521525 BXGD009139 Short neck
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740404 BXGD009991 Limb defects
C0751733 BXGD010569 Degenerative Diseases, Spinal Cord Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1301937 BXGD012300 Talipes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1302790 BXGD012313 Congenital malformation syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836542 BXGD014129 Depressed nasal bridge
C1836806 BXGD014162 Mild microcephaly
C1838705 BXGD014341 Anteriorly placed anus
C1839731 BXGD014397 11 pairs of ribs
C1854912 BXGD015441 Short long bone
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1866730 BXGD016419 Rhizomelia
C1963094 BXGD016681 Dry Skin, CTCAE
C2985280 BXGD018223 Blood Protein Measurement
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808046 BXGD019538 Breathing dysregulation
C4018871 BXGD020463 Abnormality of the respiratory system
C4021745 BXGD020752 Abnormality of the musculature
C4024950 BXGD021497 Nonprogressive encephalopathy Nervous System Diseases
C4540004 BXGD023235 VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 1
C4540014 BXGD023236 VERTEBRAL, CARDIAC, RENAL, AND LIMB DEFECTS SYNDROME 2
C4551570 BXGD023357 2-3 toe syndactyly
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000279 L-Alanine 89.09
BXGC0001273 Hippuric acid 179.17
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein