Showing entry for AP2-associated protein kinase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT014130
Protein NameAP2-associated protein kinase 1
Uniport IdQ2M2I8
GeneAAK1
Gene Id22848
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006897 endocytosis
Biological Process GO:0061024 membrane organization
Biological Process GO:0045747 positive regulation of Notch signaling pathway
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0050821 protein stabilization
Biological Process GO:2000369 regulation of clathrin-dependent endocytosis
Biological Process GO:0032880 regulation of protein localization
molecular function GO:0035612 AP-2 adaptor complex binding
molecular function GO:0005524 ATP binding
molecular function GO:0005112 Notch binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0031252 cell leading edge
cellular component GO:0005905 clathrin-coated pit
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0019897 extrinsic component of plasma membrane
cellular component GO:0043195 terminal bouton
Reactome
Pathway Id Pathway Name
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0005890 BXGD000345 Body Height
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0202239 BXGD004087 Uric acid measurement (procedure)
C0238124 BXGD004883 Necrotizing fasciitis Musculoskeletal Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein