adisease

Showing entry for Dental caries

General Disease Information
BXGD Id	BXGD000716
Disease Name	Dental caries
Disease CUI Id	C0011334
MeSH Codes	C07
Disease Class Name	Stomatognathic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000152
Human Phenotype Ontology Term	Abnormality of head or neck
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O43570	BXGT004601	Carbonic anhydrase 12	771	reviewed
O43772	BXGT004623	Mitochondrial carnitine/acylcarnitine carrier protein	788	reviewed	Transporter
O43781	BXGT004625	Dual specificity tyrosine-phosphorylation-regulated kinase 3	8444	reviewed	Kinase
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60882	BXGT004905	Matrix metalloproteinase-20	9313	reviewed	Enzyme
O95718	BXGT005392	Steroid hormone receptor ERR2	2103	reviewed	Nuclear receptor
P00451	BXGT005545	Coagulation factor VIII	2157	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02533	BXGT005887	Keratin, type I cytoskeletal 14	3861	reviewed
P02538	BXGT005888	Keratin, type II cytoskeletal 6A	3853	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03886	BXGT006108	NADH-ubiquinone oxidoreductase chain 1	4535	reviewed	Enzyme
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P03915	BXGT006114	NADH-ubiquinone oxidoreductase chain 5	4540	reviewed	Enzyme
P03923	BXGT006115	NADH-ubiquinone oxidoreductase chain 6	4541	reviewed
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04003	BXGT006124	C4b-binding protein alpha chain	722	reviewed
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P05186	BXGT006338	Alkaline phosphatase, tissue-nonspecific isozyme	249	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08476	BXGT006774	Inhibin beta A chain	3624	reviewed	Signaling
P08697	BXGT006815	Alpha-2-antiplasmin	5345	reviewed	Enzyme modulator
P08779	BXGT006824	Keratin, type I cytoskeletal 16	3868	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P11168	BXGT007663	Solute carrier family 2, facilitated glucose transporter member 2	6514	reviewed	Transporter
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11912	BXGT007758	B-cell antigen receptor complex-associated protein alpha chain	973	reviewed	Receptor
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P12955	BXGT007865	Xaa-Pro dipeptidase	5184	reviewed	Enzyme
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P16144	BXGT008200	Integrin beta-4	3691	reviewed	Receptor
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P20810	BXGT008602	Calpastatin	831	reviewed
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22223	BXGT008744	Cadherin-3	1001	reviewed
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23280	BXGT008844	Carbonic anhydrase 6	765	reviewed
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25024	BXGT009005	C-X-C chemokine receptor type 1	3577	reviewed	G-protein coupled receptor
P25025	BXGT009006	C-X-C chemokine receptor type 2	3579	reviewed	G-protein coupled receptor
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27482	BXGT009185	Calmodulin-like protein 3	810	reviewed	Calcium-binding protein
P27797	BXGT009206	Calreticulin	811	reviewed	Calcium-binding protein
P29033	BXGT009308	Gap junction beta-2 protein	2706	reviewed	Cell-cell junction
P30988	BXGT009491	Calcitonin receptor	799	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P34059	BXGT009749	N-acetylgalactosamine-6-sulfatase	2588	reviewed	Enzyme
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P41231	BXGT010240	P2Y purinoceptor 2	5029	reviewed	G-protein coupled receptor
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P48029	BXGT010606	Sodium- and chloride-dependent creatine transporter 1	6535	reviewed	Transporter
P48549	BXGT010644	G protein-activated inward rectifier potassium channel 1	3760	reviewed	Ion channel
P48637	BXGT010649	Glutathione synthetase	2937	reviewed	Enzyme
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P51684	BXGT010880	C-C chemokine receptor type 6	1235	reviewed	G-protein coupled receptor
P51884	BXGT010903	Lumican	4060	reviewed
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P55786	BXGT011125	Puromycin-sensitive aminopeptidase	9520	reviewed	Enzyme
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61011	BXGT011346	Signal recognition particle 54 kDa protein	6729	reviewed	Nucleic acid binding
P61978	BXGT011399	Heterogeneous nuclear ribonucleoprotein K	3190	reviewed	Enzyme
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P81605	BXGT011954	Dermcidin	117159	reviewed
Q01415	BXGT012587	N-acetylgalactosamine kinase	2585	reviewed	Kinase
Q01968	BXGT012626	Inositol polyphosphate 5-phosphatase OCRL-1	4952	reviewed	Enzyme
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q13255	BXGT013332	Metabotropic glutamate receptor 1	2911	reviewed	G-protein coupled receptor
Q13402	BXGT013348	Unconventional myosin-VIIa	4647	reviewed	Cellular structure
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q15149	BXGT013547	Plectin	5339	reviewed	Cellular structure
Q15223	BXGT013551	Nectin-1	5818	reviewed
Q15349	BXGT013558	Ribosomal protein S6 kinase alpha-2	6196	reviewed	Kinase
Q15485	BXGT013574	Ficolin-2	2220	reviewed	Signaling
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q2M2I8	BXGT014130	AP2-associated protein kinase 1	22848	reviewed	Kinase
Q7RTX0	BXGT017088	Taste receptor type 1 member 3	83756	reviewed	G-protein coupled receptor
Q8NET8	BXGT018557	Transient receptor potential cation channel subfamily V member 3	162514	reviewed	Ion channel
Q8TE23	BXGT018819	Taste receptor type 1 member 2	80834	reviewed	G-protein coupled receptor
Q92859	BXGT019386	Neogenin	4756	reviewed
Q9BQ65	BXGT020107	U6 snRNA phosphodiesterase	79650	reviewed
Q9NP55	BXGT021141	BPI fold-containing family A member 1	51297	reviewed
Q9UK39	BXGT021737	Nocturnin	25819	reviewed	Enzyme
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y5K2	BXGT022293	Kallikrein-4	9622	reviewed	Enzyme
Q15878	BXGT022659	Voltage-dependent R-type calcium channel subunit alpha-1E	777	reviewed	Ion channel
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
Q6P4Q7	BXGT024061	Metal transporter CNNM4	26504	reviewed
Q9H611	BXGT024211	ATP-dependent DNA helicase PIF1	80119	reviewed
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}