Showing entry for Free fatty acid receptor 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015621
Protein NameFree fatty acid receptor 4
Uniport IdQ5NUL3
GeneFFAR4
Gene Id338557
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0050873 brown fat cell differentiation
Biological Process GO:0036321 ghrelin secretion
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0046879 hormone secretion
Biological Process GO:0006954 inflammatory response
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0050710 negative regulation of cytokine secretion
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0032691 negative regulation of interleukin-1 beta production
Biological Process GO:0090275 negative regulation of somatostatin secretion
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0090336 positive regulation of brown fat cell differentiation
Biological Process GO:0043950 positive regulation of cAMP-mediated signaling
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0070094 positive regulation of glucagon secretion
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0010827 regulation of glucose transmembrane transport
Biological Process GO:0050872 white fat cell differentiation
molecular function GO:1990763 arrestin family protein binding
molecular function GO:0005504 fatty acid binding
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0008527 taste receptor activity
cellular component GO:0060170 ciliary membrane
cellular component GO:0005929 cilium
cellular component GO:0030139 endocytic vesicle
cellular component GO:0010008 endosome membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-2980736 Peptide hormone metabolism
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-388396 GPCR downstream signalling
R-HSA-392499 Metabolism of proteins
R-HSA-400508 Incretin synthesis, secretion, and inactivation
R-HSA-416476 G alpha (q) signalling events
R-HSA-444209 Free fatty acid receptors
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009363 BXGD000599 Congenital ocular coloboma (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235989 BXGD004801 Renal interstitial fibrosis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0282488 BXGD006804 Interstitial Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0373745 BXGD007966 Vitamin A measurement
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0524541 BXGD009230 Deciduoma
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600040 BXGD009684 Chronic interstitial cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1654637 BXGD013484 androgen independent prostate cancer
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2675659 BXGD017305 BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 10
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3554593 BXGD019225 RETINAL DYSTROPHY, IRIS COLOBOMA, AND COMEDOGENIC ACNE SYNDROME
C3642346 BXGD019245 Luminal B Breast Carcinoma
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C4225330 BXGD022224 MICROPHTHALMIA, ISOLATED, WITH COLOBOMA 10
C4316870 BXGD022707 Abnormality of the eye
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001089 16-Hydroxy-hexadecanoic acid 272.42
BXGC0002248 Dodecanoic acid 200.32
BXGC0003627 alpha-Linoleic acid 280.45
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0038641 Arundine 246.12
BXGC0040106 3-hydroxydodecanoic acid 216.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein