Showing entry for Tubulointerstitial fibrosis


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD016775
Disease NameTubulointerstitial fibrosis
Disease CUI IdC1969372
MeSH Codes   
Disease Class Name
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000119  
Human Phenotype Ontology TermAbnormality of the genitourinary system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 6446 reviewed Kinase
O00159 BXGT003886 Unconventional myosin-Ic 4641 reviewed Cellular structure
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O60494 BXGT004879 Cubilin 8029 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00742 BXGT005636 Coagulation factor X 2159 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00750 BXGT005642 Tissue-type plasminogen activator 5327 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01031 BXGT005720 Complement C5 727 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01042 BXGT005722 Kininogen-1 3827 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P04264 BXGT006176 Keratin, type II cytoskeletal 1 3848 reviewed
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04839 BXGT006273 Cytochrome b-245 heavy chain 1536 reviewed Ion channel
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P07438 BXGT006625 Metallothionein-1B 4490 reviewed
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08670 BXGT006810 Vimentin 7431 reviewed
P09237 BXGT006874 Matrilysin 4316 reviewed Enzyme
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P11678 BXGT007736 Eosinophil peroxidase 8288 reviewed Enzyme
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14618 BXGT008027 Pyruvate kinase PKM 5315 reviewed Kinase
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15090 BXGT008079 Fatty acid-binding protein, adipocyte 2167 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P17676 BXGT008327 CCAAT/enhancer-binding protein beta 1051 reviewed Transcription factor
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18850 BXGT008433 Cyclic AMP-dependent transcription factor ATF-6 alpha 22926 reviewed
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P21730 BXGT008687 C5a anaphylatoxin chemotactic receptor 1 728 reviewed G-protein coupled receptor
P22612 BXGT008785 cAMP-dependent protein kinase catalytic subunit gamma 5568 reviewed Kinase
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P29274 BXGT009327 Adenosine receptor A2a 135 reviewed G-protein coupled receptor
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30405 BXGT009423 Peptidyl-prolyl cis-trans isomerase F, mitochondrial 10105 reviewed
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35247 BXGT009804 Pulmonary surfactant-associated protein D 6441 reviewed Surfactant
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41222 BXGT010237 Prostaglandin-H2 D-isomerase 5730 reviewed Enzyme
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46663 BXGT010531 B1 bradykinin receptor 623 reviewed G-protein coupled receptor
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48507 BXGT010636 Glutamate--cysteine ligase regulatory subunit 2730 reviewed Enzyme
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P48775 BXGT010662 Tryptophan 2,3-dioxygenase 6999 reviewed Enzyme
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 7182 reviewed Nuclear receptor
P49767 BXGT010739 Vascular endothelial growth factor C 7424 reviewed Signaling
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P51795 BXGT010891 H(+)/Cl(-) exchange transporter 5 1184 reviewed Ion channel
P52803 BXGT010958 Ephrin-A5 1946 reviewed Signaling
P55085 BXGT011104 Proteinase-activated receptor 2 2150 reviewed G-protein coupled receptor
P55157 BXGT011108 Microsomal triglyceride transfer protein large subunit 4547 reviewed Transporter
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q00536 BXGT012535 Cyclin-dependent kinase 16 5127 reviewed Kinase
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q02363 BXGT012650 DNA-binding protein inhibitor ID-2 3398 reviewed Transcription factor
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q04446 BXGT012764 1,4-alpha-glucan-branching enzyme 2632 reviewed Enzyme
Q06830 BXGT012894 Peroxiredoxin-1 5052 reviewed Enzyme
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q09428 BXGT013036 ATP-binding cassette sub-family C member 8 6833 reviewed Transporter
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q12931 BXGT013282 Heat shock protein 75 kDa, mitochondrial 10131 reviewed Chaperone
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13618 BXGT013382 Cullin-3 8452 reviewed
Q13887 BXGT013401 Krueppel-like factor 5 688 reviewed Nucleic acid binding
Q14103 BXGT013439 Heterogeneous nuclear ribonucleoprotein D0 3184 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14469 BXGT013473 Transcription factor HES-1 3280 reviewed Transcription factor
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15582 BXGT013581 Transforming growth factor-beta-induced protein ig-h3 7045 reviewed Signaling
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q16772 BXGT013666 Glutathione S-transferase A3 2940 reviewed
Q16827 BXGT013675 Receptor-type tyrosine-protein phosphatase O 5800 reviewed
Q16832 BXGT013678 Discoidin domain-containing receptor 2 4921 reviewed Kinase
Q5NUL3 BXGT015621 Free fatty acid receptor 4 338557 reviewed
Q7Z494 BXGT017254 Nephrocystin-3 27031 reviewed
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q92831 BXGT019380 Histone acetyltransferase KAT2B 8850 reviewed
Q96AC1 BXGT019617 Fermitin family homolog 2 10979 reviewed
Q96D42 BXGT019636 Hepatitis A virus cellular receptor 1 26762 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96F46 BXGT019656 Interleukin-17 receptor A 23765 reviewed
Q96J66 BXGT019680 ATP-binding cassette sub-family C member 11 85320 reviewed Transporter
Q96KB5 BXGT019685 Lymphokine-activated killer T-cell-originated protein kinase 55872 reviewed Kinase
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96Q40 BXGT019714 Cyclin-dependent kinase 15 65061 reviewed Kinase
Q99538 BXGT019931 Legumain 5641 reviewed Enzyme
Q99558 BXGT019934 Mitogen-activated protein kinase kinase kinase 14 9020 reviewed Kinase
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 4217 reviewed Kinase
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BWP8 BXGT020153 Collectin-11 78989 reviewed Surfactant
Q9BYF1 BXGT020186 Angiotensin-converting enzyme 2 59272 reviewed Enzyme
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9H6X2 BXGT020486 Anthrax toxin receptor 1 84168 reviewed Receptor
Q9HC29 BXGT020526 Nucleotide-binding oligomerization domain-containing protein 2 64127 reviewed Enzyme
Q9NTG7 BXGT021211 NAD-dependent protein deacetylase sirtuin-3, mitochondrial 23410 reviewed Epigenetic regulator
Q9NWX6 BXGT021238 Probable tRNA(His) guanylyltransferase 54974 reviewed
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9UHI8 BXGT021701 A disintegrin and metalloproteinase with thrombospondin motifs 1 9510 reviewed Enzyme
Q9UI95 BXGT021714 Mitotic spindle assembly checkpoint protein MAD2B 10459 reviewed
Q9UKI8 BXGT021743 Serine/threonine-protein kinase tousled-like 1 9874 reviewed Kinase
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UPZ9 BXGT021804 Serine/threonine-protein kinase ICK 22858 reviewed Kinase
Q9Y239 BXGT022213 Nucleotide-binding oligomerization domain-containing protein 1 10392 reviewed Enzyme
Q9Y4K0 BXGT022280 Lysyl oxidase homolog 2 4017 reviewed
P35232 BXGT022663 Prohibitin 5245 reviewed
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q9BYC5 BXGT025656 Alpha-(1,6)-fucosyltransferase 2530 reviewed
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease