Showing entry for Phosphatidylinositol 3-kinase catalytic subunit type 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018553
Protein NamePhosphatidylinositol 3-kinase catalytic subunit type 3
Uniport IdQ8NEB9
GenePIK3C3
Gene Id5289
DomainPI3Ka; PI3K_C2; PI3_PI4_kinase
Pfam PF00454   PF00792   PF00613  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00562 Inositol phosphate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
4. Cellular Processes 4.1 Transport and catabolism hsa04136 Autophagy - other
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000045 autophagosome assembly
Biological Process GO:0006914 autophagy
Biological Process GO:0030242 autophagy of peroxisome
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0045022 early endosome to late endosome transport
Biological Process GO:0006897 endocytosis
Biological Process GO:0007032 endosome organization
Biological Process GO:0016236 macroautophagy
Biological Process GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0046854 phosphatidylinositol phosphorylation
Biological Process GO:0006497 protein lipidation
Biological Process GO:0034497 protein localization to phagophore assembly site
Biological Process GO:0016485 protein processing
Biological Process GO:0032465 regulation of cytokinesis
Biological Process GO:0050708 regulation of protein secretion
Biological Process GO:0043201 response to leucine
Biological Process GO:0034162 toll-like receptor 9 signaling pathway
molecular function GO:0016303 1-phosphatidylinositol-3-kinase activity
molecular function GO:0005524 ATP binding
molecular function GO:0016301 kinase activity
molecular function GO:0052742 phosphatidylinositol kinase activity
molecular function GO:0004672 protein kinase activity
cellular component GO:0044754 autolysosome
cellular component GO:0005930 axoneme
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005768 endosome
cellular component GO:0005770 late endosome
cellular component GO:0016020 membrane
cellular component GO:0030496 midbody
cellular component GO:0005777 peroxisome
cellular component GO:0030670 phagocytic vesicle membrane
cellular component GO:0000407 phagophore assembly site
cellular component GO:0035032 phosphatidylinositol 3-kinase complex, class III
cellular component GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I
cellular component GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II
Reactome
Pathway Id Pathway Name
R-HSA-109704 PI3K Cascade
R-HSA-112399 IRS-mediated signalling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1430728 Metabolism
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-556833 Metabolism of lipids
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
R-HSA-9612973 Autophagy
R-HSA-9678108 SARS-CoV-1 Infection
R-HSA-9679504 Translation of Replicase and Assembly of the Replication Transcription Complex
R-HSA-9679506 SARS-CoV Infections
R-HSA-9679506 SARS-CoV Infections
R-HSA-9694516 SARS-CoV-2 Infection
R-HSA-9694676 Translation of Replicase and Assembly of the Replication Transcription Complex
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035436 BXGD002550 Rheumatic Fever Infections; Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0085136 BXGD003131 Central Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0264490 BXGD005394 Acute respiratory failure Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C4042933 BXGD021885 Specific Learning Disorder Mental Disorders
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0001545 Harmine 212.25
BXGC0003705 Chloride 35.45
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein