Showing entry for Sulfuretin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0017933
Compound NameSulfuretin
Structure
FormulaC15H10O5
InchiKeyRGNXWPVNPFAADO-NSIKDUERSA-N
SMILESOc1ccc2c(c1)O/C(=C\c1ccc(c(c1)O)O)/C2=O
InchiInChI=1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6-
IUPAC(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one
Molecular Weight270.05
Pubchem Id5281295
Chembl IdCHEMBL490355
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50580
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 1534.628546 - -
reviewed BXGT020189 Serine/threonine-protein kinase 33 reviewed Kinase STK33 - - - 9630
reviewed BXGT008148 Intestinal-type alkaline phosphatase 1 reviewed Alpi - 19700 - -
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - 66300 - -
reviewed BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG - 67200 - -
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - 52900 - -
reviewed BXGT011852 Multidrug resistance protein CDR2 reviewed CDR2 - - - 424
reviewed BXGT003931 26S proteasome non-ATPase regulatory subunit 14 reviewed Enzyme PSMD14 - 23800 - -
reviewed BXGT005631 Prothrombin reviewed F2 - 21700 - -
reviewed BXGT008694 Acetylcholinesterase reviewed Ache - 698880 - -
reviewed BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 - 37030 - -
CHEMBL CHEMBL490355
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P00735 BXGT005631 Prothrombin reviewed - F2 IC50 '=' 21700 nM
Q9HBX9 BXGT020523 Relaxin receptor 1 reviewed G-protein coupled receptor RXFP1 Potency - 48943 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 36200 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 56234 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 39810 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 39810 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 39810 nM
P11802 BXGT007750 Cyclin-dependent kinase 4 reviewed Kinase CDK4 IC50 '=' 2820 nM
Q8WXD0 BXGT019009 Relaxin receptor 2 reviewed G-protein coupled receptor RXFP2 Potency - 43620 nM
P47901 BXGT010596 Vasopressin V1b receptor reviewed G-protein coupled receptor AVPR1B Potency - 43620 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 50118 nM
P11308 BXGT007684 Transcriptional regulator ERG reviewed Transcription factor ERG Potency - 35481 nM
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 IC50 '>' 100000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 15848 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 8912 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 50118 nM
P03468 BXGT006079 Neuraminidase reviewed - NA IC50 '=' 8 ug.mL-1
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 25118 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 25118 nM
P24822 BXGT008996 Intestinal-type alkaline phosphatase reviewed - Iap IC50 '=' 19700 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 1534 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 125892 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 14575 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' -2 %
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 35481 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 29600 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency - 56234 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 3793 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 8912 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 89125 nM
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache IC50 '=' 698880 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 51200 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 14125 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 35481 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 6309 nM
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Inhibition '<' 50 %
Q06187 BXGT012860 Tyrosine-protein kinase BTK reviewed Kinase BTK IC50 '=' 6020 nM
P43405 BXGT010386 Tyrosine-protein kinase SYK reviewed Kinase SYK IC50 '=' 4630 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 33807 nM
Q02763 BXGT012667 Angiopoietin-1 receptor reviewed Kinase TEK IC50 '=' 950 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 6012 nM
O14965 BXGT004117 Aurora kinase A reviewed Kinase AURKA IC50 '=' 850 nM
P10696 BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG IC50 '=' 67200 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 2238 nM
O43293 BXGT004584 Death-associated protein kinase 3 reviewed Kinase DAPK3 IC50 '=' 2330 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 28183 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 15848 nM
P51451 BXGT010848 Tyrosine-protein kinase Blk reviewed Kinase BLK IC50 '=' 2880 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a AC50 '=' 2320 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 15101 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 19952 nM
P03468 BXGT006079 Neuraminidase reviewed - NA logIC50 '=' 0 -
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI IC50 '=' 66300 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 89125 nM
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase reviewed Kinase MELK Inhibition '<' 50 %
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 IC50 '=' 37030 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '=' 37030 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 22387 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 25118 nM
Q57TT1 BXGT015153 Uncharacterized protein unreviewed - Tb927.8.6820 Potency - 31622 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '=' 4160 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '>' 80000 nM
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Inhibition '<' 50 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 17782 nM
O00487 BXGT003931 26S proteasome non-ATPase regulatory subunit 14 reviewed Enzyme PSMD14 IC50 '=' 23800 nM
Q9Z1B7 BXGT022403 Mitogen-activated protein kinase 13 reviewed - Mapk13 FC '=' 1 -
Q9WUI1 BXGT021940 Mitogen-activated protein kinase 11 reviewed - Mapk11 FC '=' 1 -
O08911 BXGT004043 Mitogen-activated protein kinase 12 reviewed - Mapk12 FC '=' 1 -
P47811 BXGT010587 Mitogen-activated protein kinase 14 reviewed - Mapk14 FC '=' 1 -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
P23458 BXGT008868 Tyrosine-protein kinase JAK1 reviewed Kinase JAK1 Inhibition '<' 50 %
P52333 BXGT010928 Tyrosine-protein kinase JAK3 reviewed Kinase JAK3 IC50 '=' 4260 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 6309 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL IC50 '=' 52900 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 5623 nM
P47199 BXGT010568 Quinone oxidoreductase reviewed - Cryz CD '=' 20 uM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 50118 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 22387 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 11577 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 56234 nM
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Activity '=' 99 %
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 17782 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 13459 nM
O60674 BXGT004892 Tyrosine-protein kinase JAK2 reviewed Kinase JAK2 IC50 '=' 9320 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Inhibition '<' 50 %
Q9H0H5 BXGT020436 Rac GTPase-activating protein 1 reviewed Enzyme modulator RACGAP1 IC50 - 20560 nM
Q00534 BXGT012533 Cyclin-dependent kinase 6 reviewed Kinase CDK6 IC50 '=' 2440 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 24 %
Q9UIK4 BXGT021720 Death-associated protein kinase 2 reviewed Kinase DAPK2 IC50 '=' 3070 nM
O94768 BXGT005331 Serine/threonine-protein kinase 17B reviewed Kinase STK17B IC50 '=' 1020 nM
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB Inhibition '<' 50 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B IC50 '=' 1950 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 23778 nM
Q8IUX4 BXGT018337 DNA dC->dU-editing enzyme APOBEC-3F reviewed Enzyme APOBEC3F Potency - 14125 nM
P78595 BXGT011852 Multidrug resistance protein CDR2 reviewed - CDR2 EC50 - 424 nM
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Inhibition '<' 50 %
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Inhibition '<' 50 %
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition '=' 20 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA TDI - - -
Q9UEE5 BXGT021671 Serine/threonine-protein kinase 17A reviewed Kinase STK17A IC50 '=' 5850 nM
Q08881 BXGT013012 Tyrosine-protein kinase ITK/TSK reviewed Kinase ITK IC50 '=' 2020 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '=' 1500 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 25118 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 3100 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Inhibition '<' 50 %
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 79432 nM
P53355 BXGT010985 Death-associated protein kinase 1 reviewed Kinase DAPK1 IC50 '=' 13150 nM
P50750 BXGT010818 Cyclin-dependent kinase 9 reviewed Kinase CDK9 IC50 '=' 2160 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF02626 Dalbergia odorifera Dalbergia odorifera Medicinal Plant
BXGF02963 Jasminum sambac Jasminum sambac Medicinal Plant
BXGF05367 Toxicodendron vernicifluum Toxicodendron vernicifluum Medicinal Plant
BXGF05403 Dipteryx odorata Dipteryx odorata Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease