Showing entry for Peptidyl-prolyl cis-trans isomerase FKBP14


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021233
Protein NamePeptidyl-prolyl cis-trans isomerase FKBP14
Uniport IdQ9NWM8
GeneFKBP14
Gene Id55033
DomainEF-hand_7; FKBP_C
Pfam PF13499   PF00254  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0036498 IRE1-mediated unfolded protein response
molecular function GO:0005509 calcium ion binding
molecular function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
cellular component GO:0005788 endoplasmic reticulum lumen
Reactome
Pathway Id Pathway Name
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0013720 BXGD000861 Ehlers-Danlos Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026707 BXGD001922 Mucopolysaccharidosis IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0155760 BXGD003817 Rupture of artery
C0162154 BXGD003922 Atrophic scar Pathological Conditions, Signs and Symptoms
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0241074 BXGD005078 Hyperextensible skin
C0266544 BXGD005691 Microcornea Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268342 BXGD005904 Ehlers-Danlos syndrome type 6 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334013 BXGD006978 Phrynoderma Skin and Connective Tissue Diseases
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0406740 BXGD008368 Kohlschutter Tonz syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases
C0410653 BXGD008444 Atlantoaxial instability
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0541794 BXGD009262 Skeletal muscle atrophy
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C0699743 BXGD009862 Congenital muscular dystrophy (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0749379 BXGD010214 Thoracolumbar scoliosis Musculoskeletal Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1578482 BXGD013427 Valgus deformities of feet Musculoskeletal Diseases
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836996 BXGD014183 Disproportionate tall stature
C1837098 BXGD014198 Easy fatigability
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1844592 BXGD014649 Soft skin
C1844820 BXGD014681 Range of joint movement increased
C1854301 BXGD015391 Motor delay Mental Disorders
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3281160 BXGD018885 EHLERS-DANLOS SYNDROME, KYPHOSCOLIOTIC TYPE, 2
C4021775 BXGD020771 High-frequency sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0023687 (S)-(+)-1,2-Propanediol 76.05
BXGC0033776 Cycloheximide 281.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein