Showing entry for C-Jun-amino-terminal kinase-interacting protein 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021801
Protein NameC-Jun-amino-terminal kinase-interacting protein 3
Uniport IdQ9UPT6
GeneMAPK8IP3
Gene Id23162
DomainJIP_LZII; Jnk-SapK_ap_N
Pfam PF16471   PF09744  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0099641 anterograde axonal protein transport
Biological Process GO:0061564 axon development
Biological Process GO:0031103 axon regeneration
Biological Process GO:0046328 regulation of JNK cascade
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0008432 JUN kinase binding
molecular function GO:0019894 kinesin binding
molecular function GO:0005078 MAP-kinase scaffold activity
molecular function GO:0030159 signaling receptor complex adaptor activity
cellular component GO:0030424 axon
cellular component GO:1904115 axon cytoplasm
cellular component GO:0044297 cell body
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0030425 dendrite
cellular component GO:0000139 Golgi membrane
cellular component GO:0030426 growth cone
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004093 BXGD000251 Asthenia Pathological Conditions, Signs and Symptoms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0085632 BXGD003215 Apathy Behavior and Behavior Mechanisms
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0239479 BXGD004982 Round face
C0241726 BXGD005110 Delayed ability to walk
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0423082 BXGD008468 Hypometric saccades
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0575802 BXGD009521 Small hand
C0576226 BXGD009527 Short foot
C0700078 BXGD009874 Decreased tendon reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0852413 BXGD010943 Abnormal muscle tone Nervous System Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1840077 BXGD014434 Anteverted nostril
C1848673 BXGD014963 Hypoplastic feet
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1854113 BXGD015382 Prominent nasal bridge
C1857482 BXGD015706 Slender finger
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861324 BXGD016029 Short philtrum
C1861403 BXGD016045 Variable expressivity
C1865014 BXGD016282 Long philtrum
C1865017 BXGD016283 Thin upper lip vermilion
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3279675 BXGD018770 Perisylvian polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022810 BXGD021005 Abnormality of nervous system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4023073 BXGD021097 EEG with temporal focal spikes
C4023074 BXGD021098 EEG with parietal focal spikes
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003342 Guanidine 59.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein