Showing entry for Cystine/glutamate transporter


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021803
Protein NameCystine/glutamate transporter
Uniport IdQ9UPY5
GeneSLC7A11
Gene Id23657
Domain_permease_2
Pfam PF13520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030534 adult behavior
Biological Process GO:0006865 amino acid transport
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0140206 dipeptide import across plasma membrane
Biological Process GO:0090461 glutamate homeostasis
Biological Process GO:0006749 glutathione metabolic process
Biological Process GO:0034775 glutathione transmembrane transport
Biological Process GO:0070306 lens fiber cell differentiation
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0098712 L-glutamate import across plasma membrane
Biological Process GO:0060173 limb development
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:1903204 negative regulation of oxidative stress-induced neuron death
Biological Process GO:0070527 platelet aggregation
Biological Process GO:1904717 regulation of AMPA glutamate receptor clustering
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:1901494 regulation of cysteine metabolic process
Biological Process GO:2000211 regulation of glutamate metabolic process
Biological Process GO:1903786 regulation of glutathione biosynthetic process
Biological Process GO:0048021 regulation of melanin biosynthetic process
Biological Process GO:0033029 regulation of neutrophil apoptotic process
Biological Process GO:0051223 regulation of protein transport
Biological Process GO:0035094 response to nicotine
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:0051775 response to redox state
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0021756 striatum development
Biological Process GO:0021591 ventricular system development
Biological Process GO:0008542 visual learning
molecular function GO:0015327 cystine:glutamate antiporter activity
molecular function GO:0015179 L-amino acid transmembrane transporter activity
cellular component GO:0045177 apical part of cell
cellular component GO:0097449 astrocyte projection
cellular component GO:0031526 brush border membrane
cellular component GO:0009986 cell surface
cellular component GO:0005856 cytoskeleton
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-210991 Basigin interactions
R-HSA-352230 Amino acid transport across the plasma membrane
R-HSA-382551 Transport of small molecules
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-425407 SLC-mediated transmembrane transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032197 BXGD002333 Platelet Storage Pool Deficiency Hemic and Lymphatic Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0079504 BXGD003080 Hermanski-Pudlak Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases
C0085090 BXGD003122 Lymphoma, AIDS-Related Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153381 BXGD003626 Malignant neoplasm of mouth Neoplasms; Stomatognathic Diseases
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220641 BXGD004305 Lip and Oral Cavity Carcinoma Neoplasms; Stomatognathic Diseases
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280734 BXGD006755 AIDS-related malignancies Neoplasms; Infections; Immune System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0521158 BXGD009130 Recurrent tumor
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1527311 BXGD013268 Brain Edema Nervous System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0006271 L-Cysteine 121.16
BXGC0024228 Cystine 240.02
BXGC0033112 Acetylcysteine 163.03
BXGC0036441 Quisqualate 189.04
BXGC0045817 Congo Red 650.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein