Showing entry for L-Cysteine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0006271
Compound NameL-Cysteine
Structure
FormulaC3H7NO2S
InchiKeyXUJNEKJLAYXESH-REOHCLBHSA-N
SMILESN[C@@H](CS)C(O)=O
InchiInChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
IUPAC(2R)-2-amino-3-sulfanylpropanoic acid
Molecular Weight121.16
Pubchem Id5862
Chembl IdCHEMBL863
Targets of Information Source
DrugBank DB00151
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P48507 BXGT010636 Glutamate--cysteine ligase regulatory subunit reviewed Enzyme GCLM approved; nutraceutical -
P48506 BXGT010635 Glutamate--cysteine ligase catalytic subunit reviewed Enzyme GCLC approved; nutraceutical -
P17174 BXGT008289 Aspartate aminotransferase, cytoplasmic reviewed - GOT1 approved; nutraceutical substrate
P00505 BXGT005560 Aspartate aminotransferase, mitochondrial reviewed - GOT2 approved; nutraceutical substrate
P32929 BXGT009682 Cystathionine gamma-lyase reviewed Enzyme CTH approved; nutraceutical -
P35520 BXGT009842 Cystathionine beta-synthase reviewed - CBS approved; nutraceutical -
P49589 BXGT010714 Cysteine--tRNA ligase, cytoplasmic reviewed Enzyme CARS approved; nutraceutical substrate
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase reviewed - MGMT approved; nutraceutical -
P48637 BXGT010649 Glutathione synthetase reviewed Enzyme GSS approved; nutraceutical -
Q9HA77 BXGT020504 Probable cysteine--tRNA ligase, mitochondrial reviewed Enzyme CARS2 approved; nutraceutical substrate
Q9Y600 BXGT022311 Cysteine sulfinic acid decarboxylase reviewed Enzyme CSAD approved; nutraceutical -
Q9Y697 BXGT022322 Cysteine desulfurase, mitochondrial reviewed Enzyme NFS1 approved; nutraceutical -
Q16878 BXGT013687 Cysteine dioxygenase type 1 reviewed - CDO1 approved; nutraceutical -
PDB CYS
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00451 BXGT005545 Coagulation factor VIII reviewed F8 Enzyme - - - -
Q9X218 BXGT022122 Aminotransferase, class V unreviewed TM_1692 - - - - -
P21310 BXGT008636 Histidine ammonia-lyase reviewed hutH - - - - -
P0A9Q9 BXGT007198 Aspartate-semialdehyde dehydrogenase reviewed asd - - - - -
P07598 BXGT006645 Periplasmic [Fe] hydrogenase large subunit reviewed hydA - - - - -
P13599 BXGT007926 IgG receptor FcRn large subunit p51 reviewed Fcgrt - - - - -
P21888 BXGT008703 Cysteine--tRNA ligase reviewed cysS - - - - -
Q9KQG2 BXGT020975 Aspartate-semialdehyde dehydrogenase 1 reviewed asd1 - - - - -
P08887 BXGT006835 Interleukin-6 receptor subunit alpha reviewed IL6R Signaling - - - -
Q9ZHG9 BXGT022456 L-cysteine/cystine lyase C-DES unreviewed c-des - - - - -
Q9Y286 BXGT022225 Sialic acid-binding Ig-like lectin 7 reviewed SIGLEC7 Receptor - - - -
P44801 BXGT010440 Aspartate-semialdehyde dehydrogenase reviewed asd - - - - -
Q00511 BXGT012529 Uricase reviewed uaZ - - - - -
P43886 BXGT010418 Serine acetyltransferase reviewed cysE - 1000 - - -
P0A9D4 BXGT007183 Serine acetyltransferase reviewed cysE - - - - -
P07013 BXGT006537 Primosomal replication protein N reviewed priB - - - - -
Q0P9S0 BXGT013123 Putative amino-acid transporter periplasmic solute-binding protein unreviewed cjaA - - - 100 -
P61626 BXGT011382 Lysozyme C reviewed LYZ - - - - -
P0A6W9 BXGT007077 Glutamate--cysteine ligase reviewed gshA - - - - -
Q9UGB7 BXGT021678 Inositol oxygenase reviewed MIOX Enzyme - - - -
Q16878 BXGT013687 Cysteine dioxygenase type 1 reviewed CDO1 - - - - -
P0AES0 BXGT007327 Bifunctional glutathionylspermidine synthetase/amidase reviewed gss - - - - -
Q99104 BXGT019910 Unconventional myosin-Va reviewed Myo5a - - - - -
P00784 BXGT005655 Papain reviewed - - - - -
P0AFX9 BXGT007358 Sigma-E factor regulatory protein RseB reviewed rseB - - - - -
Q06A71 BXGT012901 Glutathione transferase sigma class unreviewed - - - - -
Q5F5B5 BXGT015356 ABC transporter substrate-binding protein unreviewed NGO_2014 - - - 21 -
Q5F9M1 BXGT015368 Amino acid ABC transporter substrate-binding protein unreviewed NGO_0372 - - - 21 -
P01901 BXGT005813 H-2 class I histocompatibility antigen, K-B alpha chain reviewed H2-K1 - - - - -
Q68FT9 BXGT016190 Selenocysteine lyase reviewed Scly - 9600000 - - -
Q68FT9 BXGT016190 Selenocysteine lyase reviewed Scly - - - - -
O15570 BXGT004184 Cysteine synthase unreviewed - - - 1100000 -
P40702 BXGT010197 Surface presentation of antigens protein SpaS reviewed spaS - - - - -
P00889 BXGT005684 Citrate synthase, mitochondrial reviewed CS - - - - -
A0A384KMH6 BXGT000804 Serine acetyltransferase unreviewed cysE - - - - -
Q9U8X2 BXGT021647 Serine acetyltransferase unreviewed EhSAT - - - - -
P9WNX5 BXGT022710 Aspartate-semialdehyde dehydrogenase reviewed asd - - - - -
P48357 BXGT010627 Leptin receptor reviewed LEPR Signaling - - - -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed SERPINA6 Enzyme modulator - - - -
Q6XJV4 BXGT016608 Cell surface glycoprotein CD200 receptor 4 reviewed Cd200r4 - - - - -
Q9ES57 BXGT020316 Cell surface glycoprotein CD200 receptor 1 reviewed Cd200r1 - - - - -
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] reviewed SOD1 Enzyme - - - -
P43616 BXGT010402 Cys-Gly metallodipeptidase DUG1 reviewed DUG1 - - - - -
Q9KNT2 BXGT020960 Serine acetyltransferase unreviewed VC_2649 - - - - -
Q94734 BXGT019555 Nitrophorin-4 reviewed - - - - 167
P21816 BXGT008692 Cysteine dioxygenase type 1 reviewed Cdo1 - - - - -
Q739M9 BXGT016777 Metallothiol transferase FosB reviewed fosB - - - - -
P80025 BXGT011867 Lactoperoxidase reviewed LPO - - - - -
A8YBP8 BXGT001729 Cysteine synthase unreviewed IPF_3084 - - - - -
P60864 BXGT011334 Metallothiol transferase FosB reviewed fosB - - - - -
Q3MFZ5 BXGT014504 Amino acid/amide ABC transporter substrate-binding protein, HAAT family unreviewed Ava_0465 - - - - -
Q9HXN1 BXGT020651 Membrane-bound lytic murein transglycosylase F reviewed mltF - - - - -
O32085 BXGT004423 Cysteine dioxygenase reviewed cdoA - - - - -
Q9RQJ2 BXGT021484 Peptidylarginine deiminase reviewed PG_1424 - - - - -
O67141 BXGT004980 Elongation factor SelB unreviewed selB - - - - -
Q9YBL2 BXGT022363 Protein CysO reviewed cysO - - - - -
B6YT87 BXGT002231 Cysteine desulfurase unreviewed TON_0289 - - - - -
P77444 BXGT011808 Cysteine desulfurase reviewed sufS - - - - -
P38484 BXGT010042 Interferon gamma receptor 2 reviewed IFNGR2 Receptor - - - -
P32929 BXGT009682 Cystathionine gamma-lyase reviewed CTH Enzyme - - - -
P01031 BXGT005720 Complement C5 reviewed C5 Enzyme modulator - - - -
P14784 BXGT008054 Interleukin-2 receptor subunit beta reviewed IL2RB Receptor - - - -
Q15063 BXGT013531 Periostin reviewed POSTN Signaling - - - -
C6XGT2 BXGT023701 Putative amino acid-binding periplasmic ABC transporter protein unreviewed CLIBASIA_05070 - - - 1450 -
O59010 BXGT004824 Glutamate transporter homolog reviewed PH1295 - - - - -
P55899 BXGT011131 IgG receptor FcRn large subunit p51 reviewed FCGRT - - - - -
P00748 BXGT005640 Coagulation factor XII reviewed F12 Enzyme - - - -
A6TFK2 BXGT024548 Serine acetyltransferase unreviewed cysE - - - - -
O30347 BXGT024796 Glutathione S-transferase unreviewed phnC - - - - -
P14618 BXGT008027 Pyruvate kinase PKM reviewed PKM Kinase - - - -
P0DOX5 BXGT007515 Immunoglobulin gamma-1 heavy chain reviewed - - - - -
Q9C8E7 BXGT025419 Glutamate receptor 3.3 reviewed GLR3.3 - - - - -
Q2LKZ0 BXGT025622 Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 unreviewed - - - - -
P01009 BXGT005714 Alpha-1-antitrypsin reviewed SERPINA1 Enzyme modulator - - - -
P02768 BXGT005955 Serum albumin reviewed ALB Transporter - - - -
Binding DB 50109609
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005629 Carboxypeptidase A1 reviewed CPA1 350000 - - -
reviewed BXGT010948 Kinesin-like protein KIF11 reviewed Cellular structure KIF11 - >63000 - -
reviewed BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 46000000 - - -
reviewed BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 - 116000 - -
reviewed BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 59000 - - -
CHEMBL CHEMBL863
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9UPY5 BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 Activity '=' 22 %
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 pKi '=' -1 mM
Q9UPY5 BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 Drug uptake '=' 22 %
Q93UV0 BXGT019537 Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme unreviewed - SPT1 Activity - - -
P10649 BXGT007600 Glutathione S-transferase Mu 1 reviewed - Gstm1 Ratio '=' 0 -
P52732 BXGT010948 Kinesin-like protein KIF11 reviewed Cellular structure KIF11 IC50 '>' 63000 nM
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 reviewed - GSTK1 Activity '=' 0 uM min-1 (mg of protein)-1
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 reviewed - GSTK1 Activity '=' 0 uM min-1 (mg of protein)-1
P00730 BXGT005629 Carboxypeptidase A1 reviewed - CPA1 Ki '=' 350000 nM
P10649 BXGT007600 Glutathione S-transferase Mu 1 reviewed - Gstm1 Ratio '=' 0 -
Q9UPY5 BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 Ki '=' 59000 nM
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 reviewed - GSTK1 Activity '=' 0 uM min-1 (mg of protein)-1
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 reviewed - GSTK1 Activity '=' 0 uM min-1 (mg of protein)-1
Q9UPY5 BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 Activity - - -
Q93UV0 BXGT019537 Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme unreviewed - SPT1 Inhibition - - -
Q9UPY5 BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 Activity '=' 13 %
Q9UPY5 BXGT021803 Cystine/glutamate transporter reviewed Transporter SLC7A11 IC50 '=' 116000 nM
P10649 BXGT007600 Glutathione S-transferase Mu 1 reviewed - Gstm1 Ratio '=' 0 -
Q93UV0 BXGT019537 Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme unreviewed - SPT1 Activity '=' 83 %
Q93UV0 BXGT019537 Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme unreviewed - SPT1 Activity '=' 24 %
P10649 BXGT007600 Glutathione S-transferase Mu 1 reviewed - Gstm1 Ratio '=' 0 -
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 reviewed - GSTK1 Activity '=' 5 uM min-1 (mg of protein)-1
P10649 BXGT007600 Glutathione S-transferase Mu 1 reviewed - Gstm1 Ratio '=' 1 -
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 reviewed - GSTK1 Activity '=' 0 uM min-1 (mg of protein)-1
P10649 BXGT007600 Glutathione S-transferase Mu 1 reviewed - Gstm1 Ratio '=' 1 -
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
J3SE37 BXGT003735 Phosphodiesterase unreviewed - IC50 '=' 748000 nM
Q9Z1J7 BXGT022405 Amino acid transporter unreviewed - Slc1a5 Inhibition '>=' 25 %
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 Ki '=' 46000000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00006 Garden onion Allium cepa Vegetables
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00038 Tea Camellia sinensis Teas
BXGF00052 Watermelon Citrullus lanatus Gourds
BXGF00059 Arabica coffee Coffea arabica Coffee and coffee products
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00085 Soy bean Glycine max Soy
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00101 Flaxseed Linum usitatissimum Herbs and Spices
BXGF00125 Rice Oryza sativa Cereals and cereal products
BXGF00135 Date Phoenix dactylifera Fruits
BXGF00184 Linden Tilia Herbs and Spices
BXGF00187 Common wheat Triticum aestivum Cereals and cereal products
BXGF00206 Ginger Zingiber officinale Herbs and Spices
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00802 Soft-necked garlic Allium sativum L. var. sativum Herbs and Spices
BXGF02275 Trichosanthes kirilowii maxim Trichosanthes kirilowii maxim Others
BXGF05504 Silybum marianum Silybum marianum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease