Showing entry for E3 ubiquitin-protein ligase RNF168


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023493
Protein NameE3 ubiquitin-protein ligase RNF168
Uniport IdQ8IYW5
GeneRNF168
Gene Id165918
DomainProk-RING_4
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006974 cellular response to DNA damage stimulus
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0036351 histone H2A-K13 ubiquitination
Biological Process GO:0036352 histone H2A-K15 ubiquitination
Biological Process GO:0070535 histone H2A K63-linked ubiquitination
Biological Process GO:0035518 histone H2A monoubiquitination
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0045190 isotype switching
Biological Process GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
Biological Process GO:0045739 positive regulation of DNA repair
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0010212 response to ionizing radiation
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0003682 chromatin binding
molecular function GO:0042393 histone binding
molecular function GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0031491 nucleosome binding
molecular function GO:0043130 ubiquitin binding
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0035861 site of double-strand break
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-2990846 SUMOylation
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-597592 Post-translational protein modification
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004045 BXGD000249 Asphyxia Neonatorum Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006277 BXGD000387 Bronchitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011311 BXGD000714 Dengue Fever Infections
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035021 BXGD002501 Relapsing Fever Infections
C0041834 BXGD002935 Erythema Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0149516 BXGD003324 Chronic sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0233844 BXGD004620 Clumsiness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0235971 BXGD004795 Elevated alpha-fetoprotein
C0237849 BXGD004849 Peeling of skin
C0239105 BXGD004962 Conjunctival telangiectasis
C0240059 BXGD005014 Ventricular hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0270327 BXGD006074 Bedwetting Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0270922 BXGD006134 Peripheral demyelinating neuropathy Immune System Diseases; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0349588 BXGD007933 Short stature
C0424503 BXGD008532 Dysmorphic facies
C0476486 BXGD008996 Generalized enlarged lymph nodes Hemic and Lymphatic Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0557874 BXGD009444 Global developmental delay
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0581354 BXGD009561 Recurrent sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0948163 BXGD011511 Leukoaraiosis Pathological Conditions, Signs and Symptoms
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837066 BXGD014190 Recurrent viral infection Infections
C1845864 BXGD014763 Poor hand-eye coordination
C1963094 BXGD016681 Dry Skin, CTCAE
C2677792 BXGD017386 Riddle Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Immune System Diseases; Nervous System Diseases; Mental Disorders
C2919142 BXGD017867 Short Stature, CTCAE
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3277226 BXGD018711 Restrictive ventilatory defect
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3714772 BXGD019433 Recurrent fevers
C4012968 BXGD020124 Mild global developmental delay
C4021206 BXGD020578 Chromosomal breakage induced by ionizing radiation Pathological Conditions, Signs and Symptoms
C4021850 BXGD020819 Increased sensitivity to ionizing radiation
C4025790 BXGD021791 Specific learning disability
C4551915 BXGD023441 Gait Disturbance, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein