adisease

Showing entry for Weight decreased

General Disease Information
BXGD Id	BXGD011882
Disease Name	Weight decreased
Disease CUI Id	C1262477
MeSH Codes	C23
Disease Class Name	Pathological Conditions, Signs and Symptoms
Semantic Type	Finding
Human Phenotype Ontology Id	HP:0001507
Human Phenotype Ontology Term	Growth abnormality
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O15553	BXGT004181	Pyrin	4210	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O96017	BXGT005415	Serine/threonine-protein kinase Chk2	11200	reviewed	Kinase
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01308	BXGT005749	Insulin	3630	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02788	BXGT005963	Lactotransferrin	4057	reviewed	Enzyme
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04264	BXGT006176	Keratin, type II cytoskeletal 1	3848	reviewed
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06748	BXGT006497	Nucleophosmin	4869	reviewed	Chaperone
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07902	BXGT006697	Galactose-1-phosphate uridylyltransferase	2592	reviewed	Enzyme
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08397	BXGT006768	Porphobilinogen deaminase	3145	reviewed	Enzyme
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P13645	BXGT007936	Keratin, type I cytoskeletal 10	3858	reviewed
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P21333	BXGT008638	Filamin-A	2316	reviewed
P22459	BXGT008773	Potassium voltage-gated channel subfamily A member 4	3739	reviewed	Ion channel
P24158	BXGT008951	Myeloblastin	5657	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P24752	BXGT008993	Acetyl-CoA acetyltransferase, mitochondrial	38	reviewed	Enzyme
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P31040	BXGT009503	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	6389	reviewed	Enzyme
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	2556	reviewed	Ion channel
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P35914	BXGT009880	Hydroxymethylglutaryl-CoA lyase, mitochondrial	3155	reviewed	Enzyme
P36894	BXGT009939	Bone morphogenetic protein receptor type-1A	657	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40926	BXGT010207	Malate dehydrogenase, mitochondrial	4191	reviewed	Enzyme
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42658	BXGT010327	Dipeptidyl aminopeptidase-like protein 6	1804	reviewed	Enzyme
P42858	BXGT010341	Huntingtin	3064	reviewed
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P49638	BXGT010720	Alpha-tocopherol transfer protein	7274	reviewed	Transporter
P50542	BXGT010808	Peroxisomal targeting signal 1 receptor	5830	reviewed	Transporter
P50747	BXGT010817	Biotin--protein ligase	3141	reviewed	Enzyme
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P51812	BXGT010893	Ribosomal protein S6 kinase alpha-3	6197	reviewed	Kinase
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54819	BXGT011084	Adenylate kinase 2, mitochondrial	204	reviewed	Kinase
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
Q01718	BXGT012609	Adrenocorticotropic hormone receptor	4158	reviewed	G-protein coupled receptor
Q04637	BXGT012771	Eukaryotic translation initiation factor 4 gamma 1	1981	reviewed	Nucleic acid binding
Q05516	BXGT012822	Zinc finger and BTB domain-containing protein 16	7704	reviewed	Transcription factor
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q07973	BXGT012952	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	1591	reviewed	Enzyme
Q08209	BXGT012968	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	5530	reviewed
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13423	BXGT013352	NAD(P) transhydrogenase, mitochondrial	23530	reviewed	Enzyme
Q13472	BXGT013360	DNA topoisomerase 3-alpha	7156	reviewed	Enzyme
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13489	BXGT013364	Baculoviral IAP repeat-containing protein 3	330	reviewed	Enzyme modulator
Q13698	BXGT013392	Voltage-dependent L-type calcium channel subunit alpha-1S	779	reviewed	Ion channel
Q14203	BXGT013455	Dynactin subunit 1	1639	reviewed	Chaperone
Q14654	BXGT013495	ATP-sensitive inward rectifier potassium channel 11	3767	reviewed	Ion channel
Q15131	BXGT013545	Cyclin-dependent kinase 10	8558	reviewed	Kinase
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q4G0J3	BXGT014809	La-related protein 7	51574	reviewed	Nucleic acid binding
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q6PCD5	BXGT016464	E3 ubiquitin-protein ligase RFWD3	55159	reviewed	Enzyme
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8TDQ0	BXGT018810	Hepatitis A virus cellular receptor 2	84868	reviewed
Q96IV0	BXGT019677	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	55768	reviewed	Enzyme
Q96QK1	BXGT019720	Vacuolar protein sorting-associated protein 35	55737	reviewed	Transporter
Q9BZ23	BXGT020194	Pantothenate kinase 2, mitochondrial	80025	reviewed	Kinase
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9HC97	BXGT020527	G-protein coupled receptor 35	2859	reviewed	G-protein coupled receptor
Q9NNW7	BXGT021139	Thioredoxin reductase 2, mitochondrial	10587	reviewed	Enzyme
Q9NPD8	BXGT021152	Ubiquitin-conjugating enzyme E2 T	29089	reviewed
Q9NPI8	BXGT021161	Fanconi anemia group F protein	2188	reviewed
Q9NW38	BXGT021230	E3 ubiquitin-protein ligase FANCL	55120	reviewed	Enzyme
Q9NZ08	BXGT021266	Endoplasmic reticulum aminopeptidase 1	51752	reviewed	Enzyme
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9UDY8	BXGT021670	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	10892	reviewed	Enzyme
Q9UER7	BXGT021672	Death domain-associated protein 6	1616	reviewed
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9Y2M0	BXGT022241	Fanconi-associated nuclease 1	22909	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
P20036	BXGT022764	HLA class II histocompatibility antigen, DP alpha 1 chain	3113	reviewed	Immune response
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
Q99748	BXGT023217	Neurturin	4902	reviewed	Signaling
Q8IYW5	BXGT023493	E3 ubiquitin-protein ligase RNF168	165918	reviewed
P35670	BXGT023695	Copper-transporting ATPase 2	540	reviewed	Transporter
P15260	BXGT023924	Interferon gamma receptor 1	3459	reviewed	Receptor
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
P29590	BXGT024350	Protein PML	5371	reviewed
Q9H040	BXGT024831	SprT-like domain-containing protein Spartan	83932	reviewed
Q14980	BXGT025336	Nuclear mitotic apparatus protein 1	4926	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}