adisease

Showing entry for Otitis Media

General Disease Information
BXGD Id	BXGD002177
Disease Name	Otitis Media
Disease CUI Id	C0029882
MeSH Codes	C09
Disease Class Name	Otorhinolaryngologic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0002715 HP:0000598
Human Phenotype Ontology Term	Abnormality of the immune system; Abnormality of the ear
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O14920	BXGT004110	Inhibitor of nuclear factor kappa-B kinase subunit beta	3551	reviewed	Kinase
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O15553	BXGT004181	Pyrin	4210	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75663	BXGT005143	TIP41-like protein	261726	reviewed
O95347	BXGT005374	Structural maintenance of chromosomes protein 2	10592	reviewed
P00491	BXGT005555	Purine nucleoside phosphorylase	4860	reviewed	Enzyme
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08648	BXGT006804	Integrin alpha-5	3678	reviewed
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P08887	BXGT006835	Interleukin-6 receptor subunit alpha	3570	reviewed	Signaling
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10147	BXGT007543	C-C motif chemokine 3	6348	reviewed	Signaling
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P12273	BXGT007787	Prolactin-inducible protein	5304	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13647	BXGT007937	Keratin, type II cytoskeletal 5	3852	reviewed
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14598	BXGT008024	Neutrophil cytosol factor 1	653361	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15941	BXGT008176	Mucin-1	4582	reviewed
P16070	BXGT008186	CD44 antigen	960	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P16871	BXGT008269	Interleukin-7 receptor subunit alpha	3575	reviewed	Receptor
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31785	BXGT009577	Cytokine receptor common subunit gamma	3561	reviewed	Signaling
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P54802	BXGT011081	Alpha-N-acetylglucosaminidase	4669	reviewed
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P78504	BXGT011844	Protein jagged-1	182	reviewed
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q13153	BXGT013319	Serine/threonine-protein kinase PAK 1	5058	reviewed	Kinase
Q15080	BXGT013535	Neutrophil cytosol factor 4	4689	reviewed
Q76LX8	BXGT016870	A disintegrin and metalloproteinase with thrombospondin motifs 13	11093	reviewed	Enzyme
Q86UE8	BXGT017612	Serine/threonine-protein kinase tousled-like 2	11011	reviewed	Kinase
Q8NEM0	BXGT018555	Microcephalin	79648	reviewed	Nucleic acid binding
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q92993	BXGT019403	Histone acetyltransferase KAT5	10524	reviewed
Q9NP55	BXGT021141	BPI fold-containing family A member 1	51297	reviewed
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9Y2I1	BXGT022235	Nischarin	11188	reviewed	Enzyme modulator
Q9Y5X0	BXGT022305	Sorting nexin-10	29887	reviewed
P35240	BXGT022927	Merlin	4771	reviewed
O60939	BXGT023048	Sodium channel subunit beta-2	6327	reviewed	Ion channel
P07766	BXGT023327	T-cell surface glycoprotein CD3 epsilon chain	916	reviewed
Q16254	BXGT023368	Transcription factor E2F4	1874	reviewed	Nucleic acid binding
Q8IYW5	BXGT023493	E3 ubiquitin-protein ligase RNF168	165918	reviewed
Q15583	BXGT024027	Homeobox protein TGIF1	7050	reviewed	Enzyme
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
Q96SD1	BXGT025929	Protein artemis	64421	reviewed
P51798	BXGT026083	H(+)/Cl(-) exchange transporter 7	1186	reviewed	Ion channel
P07315	BXGT026109	Gamma-crystallin C	1420	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}