Showing entry for Xanthyletin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0003221
Compound NameXanthyletin
Structure
FormulaC14H12O3
InchiKeyQOTBQNVNUBKJMS-UHFFFAOYSA-N
SMILESCC1(C)OC2=C(C=C1)C=C1C=CC(=O)OC1=C2
InchiInChI=1S/C14H12O3/c1-14(2)6-5-10-7-9-3-4-13(15)16-11(9)8-12(10)17-14/h3-8H,1-2H3
IUPAC8,8-dimethyl-2H,8H-pyrano[3,2-g]chromen-2-one
Molecular Weight228.24
Pubchem Id65188
Chembl IdCHEMBL303846
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50292575
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012495 Fructose-bisphosphate aldolase reviewed fba - >1111 - -
reviewed BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 - >500000 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 150000 - -
reviewed BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase reviewed Enzyme GAPDH - 194984 - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 >100000 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 25700 - - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 21500 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 9180 - - -
reviewed BXGT018499 Carbonic anhydrase 13 reviewed CA13 8360 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 7510 - - -
CHEMBL CHEMBL303846
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 18356 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 Inhibition '=' 37 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 15003 nM
Q27686 BXGT013930 Pyruvate kinase reviewed - PYK Potency '=' 25118 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 79432 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 25700 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 44668 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 50118 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 5011 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 35481 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 150000 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 14125 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 11220 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 31622 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '>' 500000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 10691 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase reviewed Enzyme GAPDH IC50 '=' 194984 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 21500 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 3162 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 75 %
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 5623 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 23099 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 10000 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14581 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 100000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
P9WQA3 BXGT012495 Fructose-bisphosphate aldolase reviewed - fba IC50 '>' 1111 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 5011 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '>' 100000 nM
P17405 BXGT008304 Sphingomyelin phosphodiesterase reviewed Enzyme SMPD1 Potency - 31622 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 29092 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 8199 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 7510 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 9180 nM
Q8N1Q1 BXGT018499 Carbonic anhydrase 13 reviewed - CA13 Ki '=' 8360 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 85 %
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a AC50 '=' 8649 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00053 Lime Citrus aurantiifolia Fruits
BXGF00054 Lemon Citrus limon Fruits
BXGF00056 Mandarin orange (Clementine, Tangerine) Citrus reticulata Fruits
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF01140 Angelica gigas Angelica gigas Medicinal Plant
BXGF01233 Citrus hassaku Citrus hassaku Others
BXGF01360 Aphelandra chamissoniana Aphelandra chamissoniana Others
BXGF01598 Bryopsis pennata Bryopsis pennata Others
BXGF01622 Pseudotsuga japonica Pseudotsuga japonica Others
BXGF01654 Plumbago zeylanica Plumbago zeylanica Medicinal Plant
BXGF01694 Luvunga scandens Luvunga scandens Medicinal Plant
BXGF01901 Uncaria perrottetii Uncaria perrottetii Medicinal Plant
BXGF01966 Chromolaena odorata Chromolaena odorata Medicinal Plant
BXGF02448 Strychnos henningsii Strychnos henningsii Medicinal Plant
BXGF02477 Aconitum tanguticum Aconitum tanguticum Medicinal Plant
BXGF02592 Ilex affinis Ilex affinis Human Edible Plant
BXGF02641 Acanthophyllum sordidum Acanthophyllum sordidum Others
BXGF02647 Citrus tamurana Citrus tamurana Others
BXGF02667 Anaxagorea clavata Anaxagorea clavata Others
BXGF02697 Vernonia scorpioides Vernonia scorpioides Others
BXGF02735 Anagallis arvensis Anagallis arvensis Medicinal Plant
BXGF02745 Rauvolfia verticillata Rauvolfia verticillata Medicinal Plant
BXGF02747 Polyalthia stenopetala Polyalthia stenopetala Others
BXGF02834 Citrus tankan Citrus tankan Medicinal Plant
BXGF02879 Roemeria refracta Roemeria refracta Others
BXGF02913 Bougainvillea glabra Bougainvillea glabra Medicinal Plant
BXGF03144 Stenostomum lucidum Stenostomum lucidum Others
BXGF03147 Beyeria brevifolia Beyeria brevifolia Others
BXGF03421 Kaempferia pulchra Kaempferia pulchra Medicinal Plant
BXGF03534 Drosera peltata Drosera peltata Medicinal Plant
BXGF03674 Zanthoxylum ailanthoides Zanthoxylum ailanthoides Medicinal Plant
BXGF03712 Arnica nevadensis Arnica nevadensis Others
BXGF03745 Odixia angusta Odixia angusta Others
BXGF03760 Prunus laurocerasus Prunus laurocerasus Medicinal Plant
BXGF03774 Citrus rugulosa Citrus rugulosa Others
BXGF03812 Ficus formosana Ficus formosana Human Edible Plant
BXGF03843 Dipterocarpus alatus Dipterocarpus alatus Medicinal Plant
BXGF03864 Echinops amplexicaulis Echinops amplexicaulis Medicinal Plant
BXGF03873 Quercus aegilops Quercus aegilops Medicinal Plant
BXGF03883 Chloranthus tianmushanensis Chloranthus tianmushanensis Others
BXGF03890 Boenninghausenia albiflora Boenninghausenia albiflora Medicinal Plant
BXGF03897 Prosopis glandulosa Prosopis glandulosa Human Edible Plant
BXGF03916 Aria pallescens Aria pallescens Others
BXGF03926 Simira eliezeriana Simira eliezeriana Others
BXGF03939 Senecio squalidus Senecio squalidus Medicinal Plant
BXGF03951 Araujia sericifera Araujia sericifera Medicinal Plant
BXGF03966 Artemisia monogyna Artemisia monogyna Others
BXGF03986 Epaltes gariepina Epaltes gariepina Others
BXGF03991 Seriphidium cinum Seriphidium cinum Medicinal Plant
BXGF04002 Dendrosenecio kilimanjari Dendrosenecio kilimanjari Others
BXGF04009 Isodon kameba Isodon kameba Medicinal Plant
BXGF04016 Pterocarpus grandiflorus Pterocarpus grandiflorus Others
BXGF04030 Chromolaena pulchella Chromolaena pulchella Others
BXGF04041 Bursaria spinosa Bursaria spinosa Human Edible Plant
BXGF04054 Taxodium mucronatum Taxodium mucronatum Medicinal Plant
BXGF04066 Gardenia fosbergii Gardenia fosbergii Others
BXGF04073 Vitex madiensis Vitex madiensis Medicinal Plant
BXGF04144 Agnorhiza bolanderi Agnorhiza bolanderi Others
BXGF04159 Panax spinosus Panax spinosus Others
BXGF04200 Euphorbia hirta Euphorbia hirta Medicinal Plant
BXGF04376 Aconitum habaense Aconitum habaense Others
BXGF04677 Cirsium canum Cirsium canum Others
BXGF04708 Sesbania punicea Sesbania punicea Others
BXGF04791 Zanthoxylum americanum Zanthoxylum americanum Medicinal Plant
BXGF04940 Strophanthus hispidus Strophanthus hispidus Medicinal Plant
BXGF05165 Ruta graveolens Ruta graveolens Medicinal Plant
BXGF05672 Podocarpus henckelii Podocarpus henckelii Others
BXGF05704 Securidaca inappendiculata Securidaca inappendiculata Medicinal Plant
BXGF05843 Pteris prolifera Pteris prolifera Others
BXGF05987 Opuntia vulgaris Opuntia vulgaris Medicinal Plant
BXGF06144 Piper hancei Piper hancei Medicinal Plant
BXGF06208 Rosa transmorrisonensis Rosa transmorrisonensis Others
BXGF06243 Bauhinia racemosa Bauhinia racemosa Medicinal Plant
BXGF06325 Salvia lasiantha Salvia lasiantha Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease