Showing entry for Pectolinarigenin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0003452
Compound NamePectolinarigenin
Structure
FormulaC17H14O6
InchiKeyGPQLHGCIAUEJQK-UHFFFAOYSA-N
SMILESCOC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C(OC)=C2O
InchiInChI=1S/C17H14O6/c1-21-10-5-3-9(4-6-10)13-7-11(18)15-14(23-13)8-12(19)17(22-2)16(15)20/h3-8,19-20H,1-2H3
IUPAC5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Molecular Weight314.29
Pubchem Id5320438
Chembl IdCHEMBL78010
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50064896
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012754 Transcription factor p65 reviewed Transcription factor RELA - - - 2290
reviewed BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 - 32400 - -
reviewed BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 8400 - - -
reviewed BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT - 600 - -
reviewed BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT - 1500 - -
CHEMBL CHEMBL78010
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 268 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 10000 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 31622 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 15848 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 IC50 '>' 40000 nM
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B IC50 '>' 40000 nM
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A IC50 '>' 40000 nM
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E IC50 '>' 40000 nM
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C IC50 '>' 40000 nM
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B IC50 '>' 40000 nM
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB IC50 '>' 40000 nM
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 IC50 '>' 40000 nM
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A IC50 '>' 40000 nM
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A IC50 '>' 40000 nM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 IC50 '>' 40000 nM
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A IC50 '>' 40000 nM
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C IC50 '>' 40000 nM
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 IC50 '>' 40000 nM
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B IC50 '>' 40000 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Inhibition '=' 11 %
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Inhibition '=' 11 %
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Inhibition '=' 11 %
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Inhibition '=' 11 %
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Inhibition '=' 11 %
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Inhibition '=' 11 %
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Inhibition '=' 11 %
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Inhibition '=' 11 %
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Inhibition '=' 11 %
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Inhibition '=' 11 %
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Inhibition '=' 11 %
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Inhibition '=' 11 %
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Inhibition '=' 11 %
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Inhibition '=' 11 %
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Inhibition '=' 11 %
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 3548 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 22387 nM
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA EC50 '=' 2290 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 EC50 '=' 2290 nM
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 EC50 '=' 2290 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 11220 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 11220 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 1834 nM
Q27686 BXGT013930 Pyruvate kinase reviewed - PYK Potency '=' 7943 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 12589 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 3162 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 18356 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 89125 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Activity '=' 48 %
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Activity '=' 20 %
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 3162 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 5623 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Activity '=' 79 %
P34972 BXGT009779 Cannabinoid receptor 2 reviewed G-protein coupled receptor CNR2 Activity '=' 13 %
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT Activity '=' 0 %
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 17782 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 11220 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 32 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 1995 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Activity '=' 19 %
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Activity - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki '=' 8400 nM
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT Activity '=' 3 %
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT IC50 '=' 600 nM
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit reviewed Kinase KIT IC50 '=' 1500 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00019 Tarragon Artemisia dracunculus Herbs and Spices
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF00269 Asian pear Pyrus pyrifolia Fruits
BXGF00888 Echinocereus blanckii Echinocereus blanckii Others
BXGF00934 Aristolochia maxima Aristolochia maxima Medicinal Plant
BXGF01004 Rabdosia weisiensis Rabdosia weisiensis Others
BXGF01065 Artemisia capillaris Artemisia capillaris Medicinal Plant
BXGF01084 Duranta erecta Duranta erecta Medicinal Plant
BXGF01139 Alluaudia ascendens Alluaudia ascendens Others
BXGF01182 Betula mandshurica Betula mandshurica Medicinal Plant
BXGF01247 Achillea collina Achillea collina Others
BXGF01415 Mikania obtusata Mikania obtusata Others
BXGF01557 Jasminum officinale Jasminum officinale Medicinal Plant
BXGF01681 Barleria acanthoides Barleria acanthoides Medicinal Plant
BXGF01715 Bergenia purpurascens Bergenia purpurascens Medicinal Plant
BXGF01890 Trollius chinensis Trollius chinensis Medicinal Plant
BXGF01961 Polygala myrtifolia Polygala myrtifolia Others
BXGF02090 Ligularia platyglossa Ligularia platyglossa Medicinal Plant
BXGF02128 Rhodiola krylovii Rhodiola krylovii Others
BXGF02224 Rapanea myricoides Rapanea myricoides Others
BXGF02247 Crataegus sinaica Crataegus sinaica Human Edible Plant
BXGF02298 Malus asiatica Malus asiatica Medicinal Plant
BXGF02336 Marrubium globosum Marrubium globosum Others
BXGF02396 Artemisia vachanica Artemisia vachanica Others
BXGF02411 Lasiocephalus ovatus Lasiocephalus ovatus Others
BXGF02427 Montrouziera sphaeroidea Montrouziera sphaeroidea Others
BXGF02443 Cotoneaster orbicularis Cotoneaster orbicularis Others
BXGF02450 Bischofia trifoliata Bischofia trifoliata Others
BXGF02475 Uncaria sessilifructus Uncaria sessilifructus Medicinal Plant
BXGF02517 Pimpinella saxifraga Pimpinella saxifraga Medicinal Plant
BXGF02531 Caragana tibetica Caragana tibetica Medicinal Plant
BXGF02538 Macrotyloma axillare Macrotyloma axillare Others
BXGF02555 Trigonostemon reidioides Trigonostemon reidioides Medicinal Plant
BXGF02581 Euphorbia ferganensis Euphorbia ferganensis Others
BXGF02594 Arachniodes dimorphophylla Arachniodes dimorphophylla Others
BXGF02608 Oreosolen wattii Oreosolen wattii Others
BXGF02742 Discaria crenata Discaria crenata Others
BXGF02756 Schizonepeta tenuisfolia Schizonepeta tenuisfolia Others
BXGF02767 Aloe nobilis Aloe nobilis Others
BXGF02783 Hexalobus crispiflorus Hexalobus crispiflorus Medicinal Plant
BXGF02837 Tsuga heterophylla Tsuga heterophylla Medicinal Plant
BXGF02899 Euodia lunu-ankenda Euodia lunu-ankenda Others
BXGF03014 Cirsium japonicum Cirsium japonicum Medicinal Plant
BXGF03015 Gmelina arborea Gmelina arborea Medicinal Plant
BXGF03392 Paulownia tomentosa Paulownia tomentosa Medicinal Plant
BXGF03397 Trifolium pratense Trifolium pratense Medicinal Plant
BXGF03472 Tropaeolum speciosum Tropaeolum speciosum Others
BXGF03547 Physostigma venenosum Physostigma venenosum Medicinal Plant
BXGF04120 Solanum bahamense Solanum bahamense Others
BXGF04121 Cordia elaeagnoides Cordia elaeagnoides Others
BXGF04247 Tinospora smilacina Tinospora smilacina Medicinal Plant
BXGF04408 Sarcomelicope argyrophylla Sarcomelicope argyrophylla Others
BXGF04698 Isodon rubescens Isodon rubescens Others
BXGF05240 Centaurea collina Centaurea collina Others
BXGF05282 Achillea serbica Achillea serbica Others
BXGF05461 Euonymus nanus Euonymus nanus Others
BXGF05536 Millingtonia hortensis Millingtonia hortensis Medicinal Plant
BXGF05703 Sinapis nigra Sinapis nigra Medicinal Plant
BXGF05751 Vatica diospyroides Vatica diospyroides Others
BXGF05856 Isodon leucophyllus Isodon leucophyllus Medicinal Plant
BXGF05864 Ptelea viscosa Ptelea viscosa Others
BXGF06009 Picrasma quassioides Picrasma quassioides Medicinal Plant
BXGF06041 Pithecellobium clypearia Pithecellobium clypearia Medicinal Plant
BXGF06092 Schizonepeta tenuifolia Schizonepeta tenuifolia Medicinal Plant
BXGF06221 Annona rensoniana Annona rensoniana Others
BXGF06238 Gardenia jasminoides Gardenia jasminoides Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease