Showing entry for Tubulin beta-4A chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006193
Protein NameTubulin beta-4A chain
Uniport IdP04350
GeneTUBB4A
Gene Id10382
DomainTubulin; Tubulin_C
Pfam PF00091   PF03953  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05130 Pathogenic Escherichia coli infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0007017 microtubule-based process
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0031115 negative regulation of microtubule polymerization
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
molecular function GO:0005509 calcium ion binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0005200 structural constituent of cytoskeleton
cellular component GO:0005930 axoneme
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0033269 internode region of axon
cellular component GO:0005874 microtubule
cellular component GO:0043209 myelin sheath
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1632852 Macroautophagy
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-190828 Gap junction trafficking
R-HSA-190828 Gap junction trafficking
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861 Gap junction assembly
R-HSA-190861 Gap junction assembly
R-HSA-190872 Transport of connexons to the plasma membrane
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2262752 Cellular responses to stress
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380287 Centrosome maturation
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977 Post-chaperonin tubulin folding pathway
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-437239 Recycling pathway of L1
R-HSA-437239 Recycling pathway of L1
R-HSA-438064 Post NMDA receptor activation events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620924 Intraflagellar transport
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9612973 Autophagy
R-HSA-9612973 Autophagy
R-HSA-9619483 Activation of AMPK downstream of NMDARs
R-HSA-9646399 Aggrephagy
R-HSA-9646399 Aggrephagy
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
R-HSA-9663891 Selective autophagy
R-HSA-9663891 Selective autophagy
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005747 BXGD000332 Blepharospasm Eye Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013423 BXGD000838 Dystonia Musculorum Deformans Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0034152 BXGD002467 Henoch-Schoenlein Purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037773 BXGD002704 Spastic Paraplegia, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0040485 BXGD002871 Torticollis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0205711 BXGD004113 Pelizaeus-Merzbacher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0231471 BXGD004494 Abnormal posture Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0240379 BXGD005033 Open mouth (finding)
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0268575 BXGD005993 Isovaleryl-CoA dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0349588 BXGD007933 Short stature
C0393556 BXGD008089 Complicated hereditary spastic paraplegia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0683322 BXGD009782 Mental impairment
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0742028 BXGD010051 Cerebellar vermis atrophy
C0751093 BXGD010317 Dystonia, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752203 BXGD010692 Dystonia, Primary Nervous System Diseases
C0752207 BXGD010695 Familial Dystonia Nervous System Diseases
C0949445 BXGD011575 Cervical Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1527344 BXGD013275 Dysphonia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837463 BXGD014235 Narrow face
C1842364 BXGD014511 Central hypotonia
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848954 BXGD014989 Generalized dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1850573 BXGD015154 Slender build Pathological Conditions, Signs and Symptoms
C1851943 BXGD015248 DYSTONIA 4, TORSION, AUTOSOMAL DOMINANT (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1853237 BXGD015319 Isolated cases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1860315 BXGD015976 Whispering dysphonia, hereditary Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1861403 BXGD016045 Variable expressivity
C1867138 BXGD016442 Upper limb postural tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1955869 BXGD016612 Malformations of Cortical Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1963946 BXGD016707 Laryngeal dystonia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1997740 BXGD016863 Segmental dystonia Nervous System Diseases
C2676244 BXGD017329 Leukodystrophy, Hypomyelinating, 6 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2677328 BXGD017371 Cerebral hypomyelination
C2750737 BXGD017675 DIARRHEA 5, WITH TUFTING ENTEROPATHY, CONGENITAL Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Nutritional and Metabolic Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3539781 BXGD019086 Progressive cGVHD
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888090 BXGD019948 Early onset torsion dystonia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4022595 BXGD020933 Tetraplegia/tetraparesis
C4022745 BXGD020977 Abnormal basal ganglia MRI signal intensity
C4024154 BXGD021291 Sunken cheeks
C4025569 BXGD021668 Eunuchoid habitus Pathological Conditions, Signs and Symptoms
C4025790 BXGD021791 Specific learning disability
C4025882 BXGD021843 Movement abnormality of the tongue
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4520981 BXGD023051 Abnormality of the basal ganglia
C4551521 BXGD023337 Kinetic tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551563 BXGD023351 Microcephaly (physical finding)
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000303 Eupatilin 344.32
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0002018 Morin 302.24
BXGC0003452 Pectolinarigenin 314.29
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005559 3',4',5'-Trimethoxyflavone 312.32
BXGC0005982 Curcumin 368.38
BXGC0008937 Demethylnobiletin 388.37
BXGC0009047 3-Methoxynobiletin 432.42
BXGC0013582 Curcumin 368.13
BXGC0014531 5,7-Dihydroxy-3,3',4',6-Tetramethoxyflavone 374.1
BXGC0019511 Ternatin 374.1
BXGC0022140 Combretastatin 334.14
BXGC0024799 Cornigerine 383.14
BXGC0024985 (-)-Demecolcine 371.17
BXGC0025658 Vinblastine 810.42
BXGC0025812 5,4'dihydroxy-3,6,7,8,3'-Pentamethoxyflavone 404.11
BXGC0026758 Santin 344.09
BXGC0027421 Paclitaxel 853.33
BXGC0028043 Arenastatin A 606.29
BXGC0028710 Kokusaginine 259.08
BXGC0030138 Colchicine 399.17
BXGC0031622 Podofilox 414.13
BXGC0032244 10-deacetyltaxol 811.32
BXGC0033365 Gardenin 418.13
BXGC0034768 Vincristine 824.4
BXGC0034865 2-(3,4-Dimethoxyphenyl)-3-Hydroxy-5,7-Dimethoxychromen-4-One 358.11
BXGC0034941 Combretastatin A4 316.13
BXGC0035119 Cryptophycin A 654.27
BXGC0036123 Ayanin 344.09
BXGC0038619 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-3,6,8-Trimethoxychromen-4-One 390.1
BXGC0039971 3',5,7-Trihydroxy-3,4',5',6-Tetramethoxyflavone 390.1
BXGC0040019 2-Methoxy-5-(3,4,5-Trimethoxyphenethyl)Phenol 318.15
BXGC0040228 4'-Demethyldeoxypodophyllotoxin 384.12
BXGC0040364 Artesunate 384.18
BXGC0044329 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-3,6,7,8-Tetramethoxychromen-4-One 404.11
BXGC0044407 10-Deacetyltaxol B 789.34
BXGC0045260 Taxol C 847.38
BXGC0045289 10-Deacetyltaxayunnanine A 805.37
BXGC0045484 5,7-dihydroxy-3,6-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 404.11
BXGC0047749 Podoverine A 384.12
BXGC0049133 3-Desmethylcolchicin 385.15
BXGC0049213 Cephalomannine 831.35
BXGC0050385 3-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-5,6,7-Trimethoxychromen-4-One 374.1
BXGC0051028 n.a 434.12
BXGC0051100 dihydroartemisinin 284.16
BXGC0051114 Desoxypodophyllotoxin 398.14
BXGC0051401 5,7,3'-Trihydroxy-3,4'-Dimethoxyflavone 330.07
BXGC0051425 Combretastatin A-1 332.13
BXGC0052973 3,5-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-6,7-Dimethoxychromen-4-One 360.08
BXGC0053369 Centaureidin 360.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein