Showing entry for Tubulin alpha-1C chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020109
Protein NameTubulin alpha-1C chain
Uniport IdQ9BQE3
GeneTUBA1C
Gene Id84790
DomainTubulin; Tubulin_C
Pfam PF00091   PF03953  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05130 Pathogenic Escherichia coli infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051301 cell division
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0007017 microtubule-based process
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000278 mitotic cell cycle
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0005200 structural constituent of cytoskeleton
molecular function GO:0005198 structural molecule activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005874 microtubule
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0005634 nucleus
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1632852 Macroautophagy
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-190828 Gap junction trafficking
R-HSA-190828 Gap junction trafficking
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861 Gap junction assembly
R-HSA-190861 Gap junction assembly
R-HSA-190872 Transport of connexons to the plasma membrane
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2262752 Cellular responses to stress
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977 Post-chaperonin tubulin folding pathway
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-437239 Recycling pathway of L1
R-HSA-437239 Recycling pathway of L1
R-HSA-438064 Post NMDA receptor activation events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5617833 Cilium Assembly
R-HSA-5620924 Intraflagellar transport
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9612973 Autophagy
R-HSA-9612973 Autophagy
R-HSA-9619483 Activation of AMPK downstream of NMDARs
R-HSA-9646399 Aggrephagy
R-HSA-9646399 Aggrephagy
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
R-HSA-9663891 Selective autophagy
R-HSA-9663891 Selective autophagy
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005938 BXGD000351 Bone Density
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0014743 BXGD000946 Erythema Nodosum Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0039263 BXGD002805 Takayasu Arteritis Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0346163 BXGD007785 Endometrioid carcinoma ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1832588 BXGD013856 Chromosome 11p11.2 Deletion Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C1849193 BXGD015022 PEELING SKIN SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000303 Eupatilin 344.32
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0002018 Morin 302.24
BXGC0003452 Pectolinarigenin 314.29
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005559 3',4',5'-Trimethoxyflavone 312.32
BXGC0005982 Curcumin 368.38
BXGC0008937 Demethylnobiletin 388.37
BXGC0009047 3-Methoxynobiletin 432.42
BXGC0013582 Curcumin 368.13
BXGC0014531 5,7-Dihydroxy-3,3',4',6-Tetramethoxyflavone 374.1
BXGC0019511 Ternatin 374.1
BXGC0021676 Withaferin A 470.27
BXGC0022140 Combretastatin 334.14
BXGC0024799 Cornigerine 383.14
BXGC0024985 (-)-Demecolcine 371.17
BXGC0025658 Vinblastine 810.42
BXGC0025812 5,4'dihydroxy-3,6,7,8,3'-Pentamethoxyflavone 404.11
BXGC0026758 Santin 344.09
BXGC0027421 Paclitaxel 853.33
BXGC0028043 Arenastatin A 606.29
BXGC0028710 Kokusaginine 259.08
BXGC0030138 Colchicine 399.17
BXGC0031622 Podofilox 414.13
BXGC0032244 10-deacetyltaxol 811.32
BXGC0033365 Gardenin 418.13
BXGC0034768 Vincristine 824.4
BXGC0034865 2-(3,4-Dimethoxyphenyl)-3-Hydroxy-5,7-Dimethoxychromen-4-One 358.11
BXGC0034941 Combretastatin A4 316.13
BXGC0035119 Cryptophycin A 654.27
BXGC0036123 Ayanin 344.09
BXGC0038619 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-3,6,8-Trimethoxychromen-4-One 390.1
BXGC0039971 3',5,7-Trihydroxy-3,4',5',6-Tetramethoxyflavone 390.1
BXGC0040019 2-Methoxy-5-(3,4,5-Trimethoxyphenethyl)Phenol 318.15
BXGC0040228 4'-Demethyldeoxypodophyllotoxin 384.12
BXGC0040364 Artesunate 384.18
BXGC0044329 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-3,6,7,8-Tetramethoxychromen-4-One 404.11
BXGC0044407 10-Deacetyltaxol B 789.34
BXGC0045260 Taxol C 847.38
BXGC0045289 10-Deacetyltaxayunnanine A 805.37
BXGC0045484 5,7-dihydroxy-3,6-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 404.11
BXGC0047749 Podoverine A 384.12
BXGC0049133 3-Desmethylcolchicin 385.15
BXGC0049213 Cephalomannine 831.35
BXGC0050385 3-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-5,6,7-Trimethoxychromen-4-One 374.1
BXGC0051028 n.a 434.12
BXGC0051114 Desoxypodophyllotoxin 398.14
BXGC0051401 5,7,3'-Trihydroxy-3,4'-Dimethoxyflavone 330.07
BXGC0051425 Combretastatin A-1 332.13
BXGC0052973 3,5-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-6,7-Dimethoxychromen-4-One 360.08
BXGC0053369 Centaureidin 360.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein