Showing entry for Tubulin alpha-1A chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016705
Protein NameTubulin alpha-1A chain
Uniport IdQ71U36
GeneTUBA1A
Gene Id7846
DomainTubulin; Tubulin_C
Pfam PF00091   PF03953  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05130 Pathogenic Escherichia coli infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051301 cell division
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0030705 cytoskeleton-dependent intracellular transport
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0007017 microtubule-based process
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0050807 regulation of synapse organization
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0005200 structural constituent of cytoskeleton
molecular function GO:0005198 structural molecule activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005881 cytoplasmic microtubule
cellular component GO:0036464 cytoplasmic ribonucleoprotein granule
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0045121 membrane raft
cellular component GO:0005874 microtubule
cellular component GO:0015630 microtubule cytoskeleton
cellular component GO:0043209 myelin sheath
cellular component GO:0031594 neuromuscular junction
cellular component GO:0005634 nucleus
cellular component GO:0055037 recycling endosome
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1632852 Macroautophagy
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-190828 Gap junction trafficking
R-HSA-190828 Gap junction trafficking
R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-HSA-190861 Gap junction assembly
R-HSA-190861 Gap junction assembly
R-HSA-190872 Transport of connexons to the plasma membrane
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2262752 Cellular responses to stress
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2995410 Nuclear Envelope (NE) Reassembly
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380287 Centrosome maturation
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-389977 Post-chaperonin tubulin folding pathway
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-437239 Recycling pathway of L1
R-HSA-437239 Recycling pathway of L1
R-HSA-438064 Post NMDA receptor activation events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620924 Intraflagellar transport
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9612973 Autophagy
R-HSA-9612973 Autophagy
R-HSA-9619483 Activation of AMPK downstream of NMDARs
R-HSA-9646399 Aggrephagy
R-HSA-9646399 Aggrephagy
R-HSA-9648025 EML4 and NUDC in mitotic spindle formation
R-HSA-9663891 Selective autophagy
R-HSA-9663891 Selective autophagy
R-HSA-9668328 Sealing of the nuclear envelope (NE) by ESCRT-III
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-983189 Kinesins
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004930 BXGD000294 Behavior Disorders Mental Disorders
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015393 BXGD000981 Eye Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0019621 BXGD001340 Histiocytosis, Langerhans-Cell Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0020225 BXGD001367 Hydranencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0021141 BXGD001485 Inappropriate ADH Syndrome Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0029401 BXGD002135 Osteitis Deformans Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035344 BXGD002541 Retinopathy of Prematurity Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151860 BXGD003490 Acquired porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221505 BXGD004466 Lesion of brain
C0266449 BXGD005670 Congenital anomaly of brain Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases
C0266463 BXGD005675 Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0266483 BXGD005680 Pachygyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266491 BXGD005683 Neuronal heterotopia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0302892 BXGD006864 Congenital porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0338502 BXGD007192 Hypoplasia of the optic nerve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0338503 BXGD007193 Septo-Optic Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0424688 BXGD008538 Small head
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0431375 BXGD008677 Classical Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1334455 BXGD012711 Pulmonary Sclerosing Hemangioma Neoplasms; Respiratory Tract Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1636149 BXGD013482 Macular dystrophy, corneal type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1833662 BXGD013936 INCLUSION BODY MYOPATHY WITH EARLY-ONSET PAGET DISEASE AND FRONTOTEMPORAL DEMENTIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1840379 BXGD014459 Cerebellar vermis hypoplasia
C1842688 BXGD014532 Hypoplasia of the brainstem
C1843367 BXGD014576 Poor school performance
C1854301 BXGD015391 Motor delay Mental Disorders
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1879312 BXGD016571 Agyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1955869 BXGD016612 Malformations of Cortical Development Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1956147 BXGD016622 Microlissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1969029 BXGD016748 Lissencephaly 3 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2677180 BXGD017366 Congenital microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2936332 BXGD018107 Alpha-Sarcoglycanopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Nervous System Diseases; Cardiovascular Diseases
C2981150 BXGD018211 Uranostaphyloschisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3711387 BXGD019391 Autosomal Recessive Primary Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022808 BXGD021004 Cerebellar agenesis
C4082173 BXGD022087 Porencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4274995 BXGD022358 Lissencephaly with cerebellar hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000303 Eupatilin 344.32
BXGC0001403 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone 418.39
BXGC0002018 Morin 302.24
BXGC0002588 Magnesium 24.31
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0003452 Pectolinarigenin 314.29
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005559 3',4',5'-Trimethoxyflavone 312.32
BXGC0005982 Curcumin 368.38
BXGC0008937 Demethylnobiletin 388.37
BXGC0009047 3-Methoxynobiletin 432.42
BXGC0013582 Curcumin 368.13
BXGC0014531 5,7-Dihydroxy-3,3',4',6-Tetramethoxyflavone 374.1
BXGC0019511 Ternatin 374.1
BXGC0021676 Withaferin A 470.27
BXGC0022140 Combretastatin 334.14
BXGC0024799 Cornigerine 383.14
BXGC0024985 (-)-Demecolcine 371.17
BXGC0025658 Vinblastine 810.42
BXGC0025812 5,4'dihydroxy-3,6,7,8,3'-Pentamethoxyflavone 404.11
BXGC0026758 Santin 344.09
BXGC0027421 Paclitaxel 853.33
BXGC0028043 Arenastatin A 606.29
BXGC0028710 Kokusaginine 259.08
BXGC0030138 Colchicine 399.17
BXGC0031622 Podofilox 414.13
BXGC0032244 10-deacetyltaxol 811.32
BXGC0033365 Gardenin 418.13
BXGC0034768 Vincristine 824.4
BXGC0034865 2-(3,4-Dimethoxyphenyl)-3-Hydroxy-5,7-Dimethoxychromen-4-One 358.11
BXGC0034941 Combretastatin A4 316.13
BXGC0035119 Cryptophycin A 654.27
BXGC0036123 Ayanin 344.09
BXGC0038619 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-3,6,8-Trimethoxychromen-4-One 390.1
BXGC0039971 3',5,7-Trihydroxy-3,4',5',6-Tetramethoxyflavone 390.1
BXGC0040019 2-Methoxy-5-(3,4,5-Trimethoxyphenethyl)Phenol 318.15
BXGC0040228 4'-Demethyldeoxypodophyllotoxin 384.12
BXGC0040364 Artesunate 384.18
BXGC0044329 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-3,6,7,8-Tetramethoxychromen-4-One 404.11
BXGC0044407 10-Deacetyltaxol B 789.34
BXGC0045260 Taxol C 847.38
BXGC0045289 10-Deacetyltaxayunnanine A 805.37
BXGC0045484 5,7-dihydroxy-3,6-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 404.11
BXGC0047749 Podoverine A 384.12
BXGC0048845 Guanosine Triphosphate 522.99
BXGC0049133 3-Desmethylcolchicin 385.15
BXGC0049213 Cephalomannine 831.35
BXGC0050385 3-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-5,6,7-Trimethoxychromen-4-One 374.1
BXGC0051028 n.a 434.12
BXGC0051100 dihydroartemisinin 284.16
BXGC0051114 Desoxypodophyllotoxin 398.14
BXGC0051401 5,7,3'-Trihydroxy-3,4'-Dimethoxyflavone 330.07
BXGC0051425 Combretastatin A-1 332.13
BXGC0052973 3,5-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-6,7-Dimethoxychromen-4-One 360.08
BXGC0053369 Centaureidin 360.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein