Showing entry for Wogonin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0016692
Compound NameWogonin
Structure
FormulaC16H12O5
InchiKeyXLTFNNCXVBYBSX-UHFFFAOYSA-N
SMILESCOc1c(O)cc(c2c1oc(cc2=O)c1ccccc1)O
InchiInChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
IUPAC5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one
Molecular Weight284.07
Pubchem Id5281703
Chembl IdCHEMBL16171
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50140257
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 - >350000 - -
reviewed BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 - 46000 - -
reviewed BXGT012834 Prostaglandin G/H synthase 2 reviewed Ptgs2 - 1070 - -
reviewed BXGT011911 Xanthine dehydrogenase/oxidase reviewed XDH - 176100 - -
reviewed BXGT009355 Nitric oxide synthase, inducible reviewed Nos2 - 7800 - -
CHEMBL CHEMBL16171
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 12589 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 36 %
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 16360 nM
P08047 BXGT006720 Transcription factor Sp1 reviewed Nucleic acid binding SP1 Activity - - -
P35030 BXGT009784 Trypsin-3 reviewed Enzyme PRSS3 IC50 '=' 105000 nM
P07478 BXGT006630 Trypsin-2 reviewed Enzyme PRSS2 IC50 '=' 105000 nM
P07477 BXGT006629 Trypsin-1 reviewed Enzyme PRSS1 IC50 '=' 105000 nM
P35030 BXGT009784 Trypsin-3 reviewed Enzyme PRSS3 Activity - - -
P07478 BXGT006630 Trypsin-2 reviewed Enzyme PRSS2 Activity - - -
P07477 BXGT006629 Trypsin-1 reviewed Enzyme PRSS1 Activity - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Inhibition '=' 40 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q86831 BXGT017584 Polyprotein II unreviewed - Inhibition '=' 36 %
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 IC50 '>' 350000 nM
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 1070 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 37933 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 17782 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' -5 %
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Inhibition '=' 98 %
Q16445 BXGT013629 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed Ion channel GABRA6 Ki '=' 2041 nM
P31644 BXGT009557 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed Ion channel GABRA5 Ki '=' 2041 nM
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed Ion channel GABRA2 Ki '=' 2041 nM
P78334 BXGT011834 Gamma-aminobutyric acid receptor subunit epsilon reviewed Ion channel GABRE Ki '=' 2041 nM
P18505 BXGT008409 Gamma-aminobutyric acid receptor subunit beta-1 reviewed Ion channel GABRB1 Ki '=' 2041 nM
Q8N1C3 BXGT018498 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed Ion channel GABRG1 Ki '=' 2041 nM
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta reviewed Ion channel GABRD Ki '=' 2041 nM
O00591 BXGT003939 Gamma-aminobutyric acid receptor subunit pi reviewed Ion channel GABRP Ki '=' 2041 nM
P34903 BXGT009769 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed Ion channel GABRA3 Ki '=' 2041 nM
Q9UN88 BXGT021783 Gamma-aminobutyric acid receptor subunit theta reviewed Ion channel GABRQ Ki '=' 2041 nM
Q99928 BXGT019975 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed Ion channel GABRG3 Ki '=' 2041 nM
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed Ion channel GABRA4 Ki '=' 2041 nM
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 reviewed Ion channel GABRB3 Ki '=' 2041 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 Ki '=' 2041 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 Ki '=' 2041 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 Ki '=' 2041 nM
Q05769 BXGT012834 Prostaglandin G/H synthase 2 reviewed - Ptgs2 Inhibition '=' 103 %
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 '=' 46000 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Potency - 20596 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity '=' 37 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' -1 %
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 50 %
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 1000 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 '=' 7800 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 35481 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 125892 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 176100 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 50118 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00016 Peanut Arachis hypogaea Nuts
BXGF00149 Peach Prunus persica Fruits
BXGF00889 Petrosimonia monandra Petrosimonia monandra Others
BXGF01005 Dictamnus dasycarpus Dictamnus dasycarpus Medicinal Plant
BXGF01194 Stellaria dichotoma Stellaria dichotoma Others
BXGF01555 Scutellaria amoena Scutellaria amoena Medicinal Plant
BXGF01631 Anodendron affine Anodendron affine Medicinal Plant
BXGF01696 Coptis japonica Coptis japonica Medicinal Plant
BXGF01886 Crambe hispanica subsp. abyssinica Crambe hispanica subsp. abyssinica Human Edible Plant
BXGF01911 Bupleurum scorzonerifolium Bupleurum scorzonerifolium Medicinal Plant
BXGF01929 Uvaria acuminata Uvaria acuminata Medicinal Plant
BXGF02087 Utricularia vulgaris Utricularia vulgaris Medicinal Plant
BXGF02103 Astragalus mongholicus Astragalus mongholicus Medicinal Plant
BXGF02167 Scutellaria barbata Scutellaria barbata Medicinal Plant
BXGF02182 Atractylodes lancea Atractylodes lancea Medicinal Plant
BXGF02325 Helichrysum lindleyi Helichrysum lindleyi Others
BXGF02333 Saposhnikovia divaricata Saposhnikovia divaricata Medicinal Plant
BXGF02359 Eucommia ulmoides Eucommia ulmoides Medicinal Plant
BXGF02490 Stizophyllum riparium Stizophyllum riparium Others
BXGF02846 Kalmia latifolia Kalmia latifolia Medicinal Plant
BXGF02895 Caesalpinia tinctoria Caesalpinia tinctoria Medicinal Plant
BXGF02991 Scutellaria viscidula Scutellaria viscidula Medicinal Plant
BXGF03018 Anthemis auriculata Anthemis auriculata Medicinal Plant
BXGF03152 Sophora japonica Sophora japonica Medicinal Plant
BXGF03234 Plantago major Plantago major Medicinal Plant
BXGF03356 Clathrotropis brachypetala Clathrotropis brachypetala Others
BXGF03391 Dioscorea tokoro Dioscorea tokoro Medicinal Plant
BXGF03427 Phellodendron chinense Phellodendron chinense Medicinal Plant
BXGF03483 Senecio speciosus Senecio speciosus Medicinal Plant
BXGF03498 Coptis deltoidea Coptis deltoidea Medicinal Plant
BXGF03530 Kopsia hainanensis Kopsia hainanensis Others
BXGF03584 Dalbergia nigra Dalbergia nigra Others
BXGF03599 Andropogon jwarancusa Andropogon jwarancusa Medicinal Plant
BXGF03786 Euphorbia sapinii Euphorbia sapinii Others
BXGF03901 Astragalus membranaceus Astragalus membranaceus Medicinal Plant
BXGF04155 Vincetoxicum amplexicaule Vincetoxicum amplexicaule Others
BXGF04691 Oroxylum indicum Oroxylum indicum Medicinal Plant
BXGF04750 Scutellaria baicalensis Scutellaria baicalensis Medicinal Plant
BXGF04784 Coptis teeta Coptis teeta Medicinal Plant
BXGF04875 Bupleurum chinense Bupleurum chinense Medicinal Plant
BXGF04906 Andrographis herba Andrographis herba Others
BXGF05002 Scutellaria balcalensis Scutellaria balcalensis Others
BXGF05115 Andrographis paniculata Andrographis paniculata Medicinal Plant
BXGF05185 Parinari campestris Parinari campestris Human Edible Plant
BXGF05506 Coptis chinensis Coptis chinensis Medicinal Plant
BXGF06151 Scutellaria lateriflora Scutellaria lateriflora Others
BXGF06238 Gardenia jasminoides Gardenia jasminoides Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease