Showing entry for 5-hydroxytryptamine receptor 7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009777
Protein Name5-hydroxytryptamine receptor 7
Uniport IdP34969
GeneHTR7
Gene Id3363
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008015 blood circulation
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process GO:0006939 smooth muscle contraction
Biological Process GO:0042310 vasoconstriction
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0004993 G protein-coupled serotonin receptor activity
molecular function GO:0030594 neurotransmitter receptor activity
cellular component GO:0030425 dendrite
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-390666 Serotonin receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002625 BXGD000122 Amnestic Disorder Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011573 BXGD000730 Endogenous depression Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0015674 BXGD001012 Chronic Fatigue Syndrome Infections; Musculoskeletal Diseases; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020453 BXGD001390 Hyperesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020624 BXGD001450 Hypomenorrhea Pathological Conditions, Signs and Symptoms
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023186 BXGD001613 Learning Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025193 BXGD001831 Melancholia Mental Disorders
C0025261 BXGD001843 Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029227 BXGD002123 Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0086133 BXGD003265 Depressive Syndrome Mental Disorders
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0232190 BXGD004534 Vagal autonomic bradycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0233488 BXGD004583 Feeling despair Behavior and Behavior Mechanisms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234230 BXGD004635 Pain, Burning Pathological Conditions, Signs and Symptoms
C0234238 BXGD004637 Ache Pathological Conditions, Signs and Symptoms
C0234254 BXGD004648 Radiating pain Pathological Conditions, Signs and Symptoms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0282126 BXGD006796 Depression, Neurotic Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376280 BXGD007983 Anxiety States, Neurotic Mental Disorders
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0458257 BXGD008905 Pain, Splitting Pathological Conditions, Signs and Symptoms
C0458259 BXGD008906 Pain, Crushing Pathological Conditions, Signs and Symptoms
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751262 BXGD010368 Adult Learning Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751263 BXGD010369 Learning Disturbance Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751292 BXGD010380 Age-Related Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751293 BXGD010381 Memory Disorder, Semantic Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751294 BXGD010382 Memory Disorder, Spatial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751407 BXGD010429 Pain, Migratory Pathological Conditions, Signs and Symptoms
C0751408 BXGD010430 Suffering, Physical Pathological Conditions, Signs and Symptoms
C0751508 BXGD010481 Long Sleeper Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751509 BXGD010482 Short Sleeper Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751510 BXGD010483 Sleep-Related Neurogenic Tachypnea Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751511 BXGD010484 Subwakefullness Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0813142 BXGD010851 Circadian Rhythm Disorders Nervous System Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1262211 BXGD011876 Diarrhoea predominant irritable bowel syndrome
C1279420 BXGD012122 Anxiety neurosis (finding) Mental Disorders
C1300682 BXGD012281 Acute and chronic colitis Digestive System Diseases
C1301797 BXGD012299 Induced hypothermia (finding) Pathological Conditions, Signs and Symptoms
C1330966 BXGD012478 Developmental Academic Disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4042891 BXGD021882 Sleep Wake Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4750718 BXGD024071 Cyclin-dependent kinase-like 5 deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000497 Vanillin 152.15
BXGC0000538 (R)-Norepinephrine 169.18
BXGC0000548 Tryptamine 160.22
BXGC0000651 Harmalan 184.24
BXGC0000982 L-Homocysteine 135.19
BXGC0001385 Stigmasterol 412.7
BXGC0001545 Harmine 212.25
BXGC0002780 (E)-Butylidene phthalide 188.23
BXGC0003196 Aripiprazole 448.39
BXGC0003519 Ligusticide 190.24
BXGC0003610 5-Hydroxy-L-tryptophan 220.22
BXGC0004907 p-Hydroxyphenethyl trans-ferulate 314.33
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0005874 Racemethionine 149.21
BXGC0006183 L-Cystine 240.3
BXGC0006326 Imperatorin 270.28
BXGC0006366 trans-Ferulic acid 194.18
BXGC0013854 Histamine 111.08
BXGC0014522 IKONNIKOSIDE I 462.08
BXGC0015320 sinaspirolide 392.2
BXGC0016692 Wogonin 284.07
BXGC0017182 angeliferulate 404.15
BXGC0017369 N-Methyllaurotetanine 341.16
BXGC0021210 Phenylpropanolamine 151.1
BXGC0023362 Fukinolic Acid 434.08
BXGC0025398 (8S,9Z)-8-Hydroxy-1-methoxy-9-heptadecene-4,6-diyne-3-one 290.19
BXGC0027118 Tamsulosin 408.17
BXGC0031558 Baicalin 446.08
BXGC0033089 Falcarindiol 260.18
BXGC0035825 Dihydrobaicalin 448.1
BXGC0036214 n.a 332.2
BXGC0038299 Ephedrine 165.12
BXGC0038837 Pseudohypericin 520.08
BXGC0038980 cathinone 149.08
BXGC0040582 nantenine 339.15
BXGC0040683 senkyunolide I 224.1
BXGC0041309 10-angeloylbutylphthalide 288.14
BXGC0041695 Sinapic Acid Methyl Ether 238.08
BXGC0042222 Propranolol 259.16
BXGC0042462 Cysteine 121.02
BXGC0042491 Z-6-hydroxy-7-methoxydihydroligustilide 238.12
BXGC0042974 N-butylbenzenesulfonamide 213.08
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
BXGC0044080 Scutellarin 462.08
BXGC0045812 Trifluoperazine 407.16
BXGC0045903 1,3-dilinolenin 612.48
BXGC0046069 n.a 276.17
BXGC0046755 Yohimbine 354.19
BXGC0047035 ansaspirolide 378.18
BXGC0050001 Oplopandiol 262.19
BXGC0052798 5-Meo-Dmt 218.14
BXGC0053872 Glaucine 355.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein