Showing entry for Gamma-aminobutyric acid receptor subunit delta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004094
Protein NameGamma-aminobutyric acid receptor subunit delta
Uniport IdO14764
GeneGABRD
Gene Id2563
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0007165 signal transduction
molecular function GO:0005254 chloride channel activity
molecular function GO:0004890 GABA-A receptor activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0030424 axon
cellular component GO:0034707 chloride channel complex
cellular component GO:0030425 dendrite
cellular component GO:1902711 GABA-A receptor complex
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020505 BXGD001412 Hyperphagia Pathological Conditions, Signs and Symptoms
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023221 BXGD001619 Leg Length Inequality Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026633 BXGD001910 Mouth Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039446 BXGD002811 Telangiectasis Cardiovascular Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0078917 BXGD003054 Albinism, Ocular Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0086543 BXGD003294 Cataract Eye Diseases
C0149955 BXGD003394 Annular pancreas Digestive System Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151311 BXGD003412 Cranial nerve palsies Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0158734 BXGD003904 Polydactyly of toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0221074 BXGD004388 Depression, Postpartum Female Urogenital Diseases and Pregnancy Complications; Mental Disorders
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0233565 BXGD004590 Bradykinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241654 BXGD005104 Abnormal heart valve morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0265695 BXGD005566 Congenital fusion of ribs Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266623 BXGD005702 Congenital anomaly of neck Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268800 BXGD006041 Simple renal cyst Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270834 BXGD006114 Complex partial seizure with impairment of consciousness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0277828 BXGD006480 Late fontanel closure
C0332573 BXGD006895 Macule
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0349588 BXGD007933 Short stature
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0426900 BXGD008596 Tibial torsion
C0431380 BXGD008680 Cortical Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0576226 BXGD009527 Short foot
C0678230 BXGD009750 Congenital Epicanthus
C0751122 BXGD010325 Infantile Severe Myoclonic Epilepsy Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0856748 BXGD011113 Aneurysm of aortic arch Cardiovascular Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1611743 BXGD013456 Familial (FPAH)
C1834433 BXGD013973 Obsessive-compulsive trait Behavior and Behavior Mechanisms
C1836542 BXGD014129 Depressed nasal bridge
C1836830 BXGD014165 Developmental regression Mental Disorders
C1839333 BXGD014369 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 Nervous System Diseases
C1839731 BXGD014397 11 pairs of ribs
C1842870 BXGD014541 Chromosome 1p36 Deletion Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1842876 BXGD014542 Depressed nasal ridge
C1844505 BXGD014633 Pointed chin
C1844690 BXGD014662 Limited knee extension
C1846131 BXGD014783 Photosensitive tonic-clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1847164 BXGD014854 Morning myoclonic jerks Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848673 BXGD014963 Hypoplastic feet
C1849211 BXGD015023 Generalized hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1849367 BXGD015046 Nasal bridge wide
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853242 BXGD015322 Midface retrusion
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1855925 BXGD015561 Hyperopia, High Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1861329 BXGD016033 Spinal canal stenosis Musculoskeletal Diseases
C1865014 BXGD016282 Long philtrum
C1867864 BXGD016472 Poor fine motor coordination
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1997217 BXGD016859 Low grade glioma Neoplasms
C2132198 BXGD016930 Abnormal blistering of the skin
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2674608 BXGD017250 Feeding difficulties in infancy
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2751603 BXGD017728 EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 10
C2919142 BXGD017867 Short Stature, CTCAE
C3277019 BXGD018698 Horizontal eyebrow
C3278923 BXGD018748 Dilated ventricles (finding)
C3502809 BXGD019049 Generalized Epilepsy with Febrile Seizures Plus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4021757 BXGD020760 EEG with polyspike wave complexes
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021822 BXGD020807 Abnormality of female external genitalia
C4023511 BXGD021206 Obtundation status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023683 BXGD021240 EEG with spike-wave complexes
C4024945 BXGD021492 Generalized cerebral atrophy/hypoplasia
C4025329 BXGD021647 Abnormality of the anus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4025749 BXGD021773 Abnormality of the spleen
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
C4316788 BXGD022697 Abnormality of the intestine
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505072 BXGD022953 Epileptic Syndromes Nervous System Diseases
C4551583 BXGD023361 Cerebral cortical atrophy
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721788 BXGD023771 Bifid ribs
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001778 Scutellarein 286.24
BXGC0002064 Amentoflavone 538.46
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002867 Lappaurin 284.74
BXGC0003776 Flavones 222.24
BXGC0003885 Lormetazepam 335.19
BXGC0003886 N-Demethyldiazepam 270.71
BXGC0004115 Norharman 168.19
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005793 Baicalein 270.24
BXGC0005867 Serotonin 176.22
BXGC0007014 Harman 182.22
BXGC0008167 Chrysin 254.24
BXGC0016692 Wogonin 284.07
BXGC0030085 Bicuculline 367.11
BXGC0031558 Baicalin 446.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein