Showing entry for Gamma-aminobutyric acid receptor subunit alpha-3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009769
Protein NameGamma-aminobutyric acid receptor subunit alpha-3
Uniport IdP34903
GeneGABRA3
Gene Id2556
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0007214 gamma-aminobutyric acid signaling pathway
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0060078 regulation of postsynaptic membrane potential
Biological Process GO:0007165 signal transduction
Biological Process GO:0051932 synaptic transmission, GABAergic
molecular function GO:0008503 benzodiazepine receptor activity
molecular function GO:0005254 chloride channel activity
molecular function GO:0004890 GABA-A receptor activity
molecular function GO:0022851 GABA-gated chloride ion channel activity
molecular function GO:0005237 inhibitory extracellular ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0034707 chloride channel complex
cellular component GO:0032590 dendrite membrane
cellular component GO:1902711 GABA-A receptor complex
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-977443 GABA receptor activation
R-HSA-977443 GABA receptor activation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0020458 BXGD001393 Hyperhidrosis disorder Skin and Connective Tissue Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0034372 BXGD002480 Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035232 BXGD002517 Respiratory Paralysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0080274 BXGD003111 Urinary Retention Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0151878 BXGD003495 Prolonged QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0154141 BXGD003703 Thyrotoxicosis with toxic single thyroid nodule Endocrine System Diseases
C0154143 BXGD003704 Toxic multinodular goiter Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221170 BXGD004400 Muscular stiffness Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238358 BXGD004917 Hypokalemic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262404 BXGD005236 Cerebellar degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0264906 BXGD005434 Second degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0268024 BXGD005803 Hyperkalemia, diminished renal excretion Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268446 BXGD005949 Thyrotoxic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0410203 BXGD008417 X-linked centronuclear myopathy Musculoskeletal Diseases; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0476403 BXGD008992 Electromyogram abnormal
C0520878 BXGD009117 Shortened PR interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0751401 BXGD010427 Ophthalmoparesis Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1836296 BXGD014105 Muscle Weakness Lower Limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1855520 BXGD015506 Hyperglycemia, Postprandial Nutritional and Metabolic Diseases
C1855580 BXGD015515 Exercise-induced muscle fatigue
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3160712 BXGD018467 Palpitations, CTCAE
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714697 BXGD019424 AV Block Second Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4020730 BXGD020473 Increased intramyocellular lipid droplets
C4021553 BXGD020669 Periodic hypokalemic paresis
C4022754 BXGD020983 Episodic hypokalemia Nutritional and Metabolic Diseases
C4024709 BXGD021380 Transient hypophosphatemia Nutritional and Metabolic Diseases
C4025572 BXGD021671 Episodic flaccid weakness Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4025578 BXGD021675 Late-onset proximal muscle weakness
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4552839 BXGD023527 Hypomagnesemia, CTCAE
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001778 Scutellarein 286.24
BXGC0001841 Batatasin III 244.29
BXGC0002064 Amentoflavone 538.46
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002867 Lappaurin 284.74
BXGC0003776 Flavones 222.24
BXGC0003885 Lormetazepam 335.19
BXGC0003886 N-Demethyldiazepam 270.71
BXGC0003963 Dechlorodiazepam 250.3
BXGC0004115 Norharman 168.19
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005793 Baicalein 270.24
BXGC0005867 Serotonin 176.22
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0007014 Harman 182.22
BXGC0008167 Chrysin 254.24
BXGC0014991 Ethyl Beta-Carboline-3-Carboxylate 240.09
BXGC0016692 Wogonin 284.07
BXGC0021836 Honokiol 266.13
BXGC0025485 Transtorine 189.04
BXGC0028885 Secobarbital 238.13
BXGC0030085 Bicuculline 367.11
BXGC0031558 Baicalin 446.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein