Showing entry for Gamma-aminobutyric acid receptor subunit beta-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008409
Protein NameGamma-aminobutyric acid receptor subunit beta-1
Uniport IdP18505
GeneGABRB1
Gene Id2560
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05033 Nicotine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071420 cellular response to histamine
Biological Process GO:0021954 central nervous system neuron development
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0007214 gamma-aminobutyric acid signaling pathway
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0042698 ovulation cycle
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0032570 response to progesterone
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0007165 signal transduction
molecular function GO:0004890 GABA-A receptor activity
molecular function GO:0022851 GABA-gated chloride ion channel activity
molecular function GO:0050811 GABA receptor binding
molecular function GO:0015276 ligand-gated ion channel activity
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
cellular component GO:0034707 chloride channel complex
cellular component GO:0005737 cytoplasm
cellular component GO:0030425 dendrite
cellular component GO:1902711 GABA-A receptor complex
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005635 nuclear envelope
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1236394 Signaling by ERBB4
R-HSA-162582 Signal Transduction
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-977443 GABA receptor activation
R-HSA-977443 GABA receptor activation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0019147 BXGD001289 Hepatic Coma Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270496 BXGD006076 Schizoaffective disorder, bipolar type Mental Disorders
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0596887 BXGD009648 mathematical ability
C0684276 BXGD009793 Hypsarrhythmia Nervous System Diseases
C0751197 BXGD010345 Fulminant Hepatic Failure with Cerebral Edema Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0751198 BXGD010346 Hepatic Stupor Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1856689 BXGD015630 FRIEDREICH ATAXIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4310691 BXGD022626 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 45
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0000964 6-Methylscutellarein 300.26
BXGC0001778 Scutellarein 286.24
BXGC0002064 Amentoflavone 538.46
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002867 Lappaurin 284.74
BXGC0003776 Flavones 222.24
BXGC0003885 Lormetazepam 335.19
BXGC0003886 N-Demethyldiazepam 270.71
BXGC0004115 Norharman 168.19
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005793 Baicalein 270.24
BXGC0005867 Serotonin 176.22
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0007014 Harman 182.22
BXGC0008167 Chrysin 254.24
BXGC0016692 Wogonin 284.07
BXGC0021836 Honokiol 266.13
BXGC0025485 Transtorine 189.04
BXGC0030085 Bicuculline 367.11
BXGC0031558 Baicalin 446.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein