Showing entry for Hypoxia-inducible factor 1-alpha inhibitor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021234
Protein NameHypoxia-inducible factor 1-alpha inhibitor
Uniport IdQ9NWT6
GeneHIF1AN
Gene Id55662
DomainCupin_8
Pfam PF13621  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045746 negative regulation of Notch signaling pathway
Biological Process GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0042265 peptidyl-asparagine hydroxylation
Biological Process GO:0042264 peptidyl-aspartic acid hydroxylation
Biological Process GO:0036138 peptidyl-histidine hydroxylation
Biological Process GO:0045663 positive regulation of myoblast differentiation
Biological Process GO:2001214 positive regulation of vasculogenesis
Biological Process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
molecular function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
molecular function GO:0071532 ankyrin repeat binding
molecular function GO:0031406 carboxylic acid binding
molecular function GO:0008198 ferrous iron binding
molecular function GO:0102113 hypoxia-inducible factor-asparagine oxygenase activity
molecular function GO:0051059 NF-kappaB binding
molecular function GO:0005112 Notch binding
molecular function GO:0019826 oxygen sensor activity
molecular function GO:0036140 peptidyl-asparagine 3-dioxygenase activity
molecular function GO:0036139 peptidyl-histidine dioxygenase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1234174 Cellular response to hypoxia
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0202177 BXGD004079 Phospholipid measurement
C0238284 BXGD004903 Acute mountain sickness Respiratory Tract Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1281901 BXGD012133 Fatty acid measurement
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1860224 BXGD015967 ABLEPHARON-MACROSTOMIA SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Stomatognathic Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4748839 BXGD024033 MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 32
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000436 Glycerol 92.09
BXGC0000764 L-Ascorbic acid 176.12
BXGC0001380 Succinic acid 118.09
BXGC0002485 2-Oxopentanedioic acid 146.1
BXGC0005683 Quercetin 302.24
BXGC0005793 Baicalein 270.24
BXGC0029784 Fumaric Acid 116.01
BXGC0042127 Oxyquinoline 145.05
BXGC0043436 D-Hydroxyglutarate 148.04
BXGC0044092 Daminozide 160.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein