protein

Showing entry for Egl nine homolog 1

General Target Information
BXGT Id	BXGT020425
Protein Name	Egl nine homolog 1
Uniport Id	Q9GZT9
Gene	EGLN1
Gene Id	54583
Domain	2OG-FeII_Oxy_3; zf-MYND
Pfam	PF13640 PF01753
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.2 Signal transduction	hsa04066	HIF-1 signaling pathway
6. Human Diseases	6.1 Cancers: Overview	hsa05200	Pathways in cancer
6. Human Diseases	6.2 Cancers: Specific types	hsa05211	Renal cell carcinoma

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0071456	cellular response to hypoxia
Biological Process	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity
Biological Process	GO:0032364	oxygen homeostasis
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Biological Process	GO:0045765	regulation of angiogenesis
Biological Process	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0071731	response to nitric oxide
molecular function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity
molecular function	GO:0019899	enzyme binding
molecular function	GO:0008198	ferrous iron binding
molecular function	GO:0031418	L-ascorbic acid binding
molecular function	GO:0031545	peptidyl-proline 4-dioxygenase activity
molecular function	GO:0031543	peptidyl-proline dioxygenase activity
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0005634	nucleus

Reactome

Pathway Id	Pathway Name
R-HSA-1234174	Cellular response to hypoxia
R-HSA-1234174	Cellular response to hypoxia
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-2262752	Cellular responses to stress
R-HSA-2262752	Cellular responses to stress
R-HSA-8953897	Cellular responses to external stimuli
R-HSA-8953897	Cellular responses to external stimuli

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002351	BXGD000108	Altitude Sickness	Respiratory Tract Diseases
C0002871	BXGD000132	Anemia	Hemic and Lymphatic Diseases
C0003130	BXGD000183	Anoxia	Pathological Conditions, Signs and Symptoms
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007103	BXGD000426	Malignant neoplasm of endometrium	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007134	BXGD000443	Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007786	BXGD000486	Brain Ischemia	Nervous System Diseases; Cardiovascular Diseases
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0014335	BXGD000908	Enteritis	Digestive System Diseases
C0014772	BXGD000948	Red Blood Cell Count measurement
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0015826	BXGD001022	Fenestration (morphologic abnormality)
C0017636	BXGD001131	Glioblastoma	Neoplasms
C0018609	BXGD001208	Hartnup Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Nervous System Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0018935	BXGD001252	Hematocrit procedure
C0019562	BXGD001336	Von Hippel-Lindau Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0020488	BXGD001402	Hypernatremia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0023418	BXGD001642	leukemia	Neoplasms
C0024419	BXGD001769	Waldenstrom Macroglobulinemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0025202	BXGD001832	melanoma	Neoplasms
C0026470	BXGD001903	Monoclonal Gammopathy of Undetermined Significance	Immune System Diseases; Hemic and Lymphatic Diseases
C0026764	BXGD001928	Multiple Myeloma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027543	BXGD001997	Avascular necrosis of bone	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030421	BXGD002218	Paraganglioma	Neoplasms
C0030422	BXGD002219	Extra-Adrenal Paraganglioma	Neoplasms
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0031511	BXGD002304	Pheochromocytoma	Neoplasms
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032461	BXGD002356	Polycythemia	Hemic and Lymphatic Diseases
C0034069	BXGD002458	Pulmonary Fibrosis	Respiratory Tract Diseases
C0035222	BXGD002513	Respiratory Distress Syndrome, Adult	Respiratory Tract Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0149504	BXGD003322	Encephalopathy, Toxic	Nervous System Diseases; Chemically-Induced Disorders
C0149782	BXGD003365	Squamous cell carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0151650	BXGD003454	Renal fibrosis	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0152264	BXGD003577	Familial erythrocytosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0154659	BXGD003725	Toxic Encephalitis	Nervous System Diseases; Chemically-Induced Disorders
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0158266	BXGD003878	Intervertebral Disc Degeneration	Musculoskeletal Diseases
C0162534	BXGD003953	Prion Diseases	Infections; Nervous System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0233532	BXGD004589	Maladaptive behavior associated with physical illness	Behavior and Behavior Mechanisms
C0235032	BXGD004715	Neurotoxicity Syndromes	Nervous System Diseases; Chemically-Induced Disorders
C0238284	BXGD004903	Acute mountain sickness	Respiratory Tract Diseases
C0239935	BXGD005007	Hematocrit increased
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0268641	BXGD006019	Amino acid transport disorder	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271084	BXGD006159	Exudative age-related macular degeneration	Eye Diseases
C0274294	BXGD006367	Chronic mountain sickness	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0278878	BXGD006609	Adult Glioblastoma	Neoplasms
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280141	BXGD006716	Acute Undifferentiated Leukemia
C0280474	BXGD006748	Childhood Glioblastoma	Neoplasms
C0302592	BXGD006851	Cervix carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0340100	BXGD007304	High altitude pulmonary edema	Respiratory Tract Diseases
C0349658	BXGD007947	Trichoepithelioma	Neoplasms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0549448	BXGD009381	Hemoglobin increased	Neoplasms; Hemic and Lymphatic Diseases
C0585129	BXGD009584	Retroperitoneal sarcoma	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935	BXGD009674	Tumor Initiation	Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0751435	BXGD010440	Hyperphenylalaninaemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0853662	BXGD010975	Oestrogen deficiency
C0853879	BXGD010982	Invasive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0947751	BXGD011494	Vascular inflammations	Cardiovascular Diseases
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C0948249	BXGD011521	Femoral artery occlusion	Cardiovascular Diseases
C1136084	BXGD011708	Plasma cell dyscrasia	Immune System Diseases; Hemic and Lymphatic Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401	BXGD011792	Squamous cell carcinoma of the head and neck	Neoplasms
C1261473	BXGD011855	Sarcoma	Neoplasms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1318485	BXGD012394	Liver regeneration disorder	Digestive System Diseases
C1378511	BXGD012932	Undifferentiated leukemia
C1458155	BXGD013136	Mammary Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C1512694	BXGD013193	Increased Cellularity Present
C1519670	BXGD013241	Tumor Angiogenesis	Pathological Conditions, Signs and Symptoms
C1533592	BXGD013316	Malignant Paraganglionic Neoplasm	Neoplasms
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1621958	BXGD013468	Glioblastoma Multiforme	Neoplasms
C1708353	BXGD013599	Hereditary Paraganglioma-Pheochromocytoma Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C1719672	BXGD013659	Severe Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C1847640	BXGD014879	KUFOR-RAKEB SYNDROME	Nervous System Diseases
C1853286	BXGD015328	Erythrocytosis, Familial, 3	Hemic and Lymphatic Diseases
C1853288	BXGD015329	Increased red blood cell mass	Hemic and Lymphatic Diseases
C1860224	BXGD015967	ABLEPHARON-MACROSTOMIA SYNDROME	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Stomatognathic Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2609414	BXGD017182	Acute kidney injury	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2826323	BXGD017790	Refractory Cytopenia of Childhood
C4045968	BXGD021887	Altitude Hypoxia	Respiratory Tract Diseases
C4551637	BXGD023379	Erythrocytosis familial, 1	Hemic and Lymphatic Diseases
C4551683	BXGD023389	Adrenal Gland Pheochromocytoma	Neoplasms; Endocrine System Diseases
C4551686	BXGD023391	Malignant neoplasm of soft tissue	Neoplasms
C4688007	BXGD023582	Platinum-Resistant Ovarian Carcinoma
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4728046	BXGD023884	Diabetic wound
C4749274	BXGD024052	Chuvash erythrocytosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0000505	Protocatechuic acid		154.12
BXGC0000764	L-Ascorbic acid		176.12
BXGC0001002	1,2-Benzenediol		110.11
BXGC0001380	Succinic acid		118.09
BXGC0001857	Caffeic acid		180.16
BXGC0002431	Isocitric acid		192.12
BXGC0002485	2-Oxopentanedioic acid		146.1
BXGC0003705	Chloride		35.45
BXGC0003915	Maslic acid		134.09
BXGC0004266	2-Propanol		60.1
BXGC0005701	2,3-Butanediol		90.12
BXGC0005793	Baicalein		270.24
BXGC0006198	Citric acid		192.12
BXGC0006368	Formic acid		46.03
BXGC0008661	Iron		55.85
BXGC0025746	Hydroxyproline		131.06
BXGC0029784	Fumaric Acid		116.01
BXGC0030123	Ethyl 3,4-Dihydroxybenzoate		182.06
BXGC0030612	tetraethylene glycol		194.12
BXGC0044092	Daminozide		160.08
BXGC0049447	acetate		59.01

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}