Showing entry for 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methyl-2,3-Dihydrochromen-4-One


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0042397
Compound Name5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methyl-2,3-Dihydrochromen-4-One
Structure
FormulaC16H14O5
InchiKeySLFZBNOERHGNMI-UHFFFAOYSA-N
SMILESOc1ccc(cc1)C1CC(=O)c2c(O1)cc(c(c2O)C)O
InchiInChI=1S/C16H14O5/c1-8-11(18)6-14-15(16(8)20)12(19)7-13(21-14)9-2-4-10(17)5-3-9/h2-6,13,17-18,20H,7H2,1H3
IUPAC5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydrochromen-4-one
Molecular Weight286.08
Pubchem Id301798
Chembl IdCHEMBL484640
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50571
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 3944.081622 - -
reviewed BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B - 13100 - -
reviewed BXGT020426 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 reviewed CTDSP1 - 4744 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 13273 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 9391 - -
CHEMBL CHEMBL484640
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 95283 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency - 5011 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency - 6701 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 56234 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 8912 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 44668 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 4466 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 14125 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 10000 nM
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 17782 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 5804 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 5804 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 5804 nM
Q9GZU7 BXGT020426 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 reviewed - CTDSP1 IC50 '=' 4744 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 19952 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 3981 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 25118 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 25118 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 3944 nM
Q02410 BXGT012652 Amyloid-beta A4 precursor protein-binding family A member 1 reviewed Transporter APBA1 IC50 '>' 50000 nM
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B IC50 '>' 50000 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 1584 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 50118 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 22387 nM
Q02410 BXGT012652 Amyloid-beta A4 precursor protein-binding family A member 1 reviewed Transporter APBA1 IC50 '=' 13100 nM
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B IC50 '=' 13100 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency - 14125 nM
P04608 BXGT006236 Protein Tat reviewed - tat IC50 - 37150 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 1258 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 25118 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 125892 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 89125 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease