acompound

Showing entry for Corosolic Acid

General Compound Information
BXGC Id	BXGC0049758
Compound Name	Corosolic Acid
Structure
Formula	C30H48O4
InchiKey	HFGSQOYIOKBQOW-ZSDYHTTISA-N
SMILES	C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C)(C)CC[C@@H]1[C@]3(C)C[C@@H](O)[C@@H](C1(C)C)O)C(=O)O
Inchi	InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
IUPAC	(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
Molecular Weight	472.36
Pubchem Id	6918774
Chembl Id	CHEMBL391533

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50222205

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT006496	DNA polymerase beta	reviewed	Enzyme	POLB	-	12600	-	-
reviewed	BXGT009335	Tyrosine-protein phosphatase non-receptor type 6	reviewed		PTPN6	-	24560	-	-
reviewed	BXGT007581	Receptor-type tyrosine-protein phosphatase F	reviewed	Enzyme	PTPRF	-	>40000	-	-
reviewed	BXGT008403	Receptor-type tyrosine-protein phosphatase alpha	reviewed	Enzyme	PTPRA	-	>40000	-	-
reviewed	BXGT008871	Receptor-type tyrosine-protein phosphatase epsilon	reviewed	Enzyme	PTPRE	-	>40000	-	-
reviewed	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	reviewed		PTPN1	-	5490	-	-
reviewed	BXGT008330	Tyrosine-protein phosphatase non-receptor type 2	reviewed		PTPN2	-	11310	-	-
reviewed	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	reviewed		HSD11B1	-	810	-	-
reviewed	BXGT005553	Glycogen phosphorylase, muscle form	reviewed		PYGM	-	20000	-	-
reviewed	BXGT007674	Glycogen phosphorylase, muscle form	reviewed	Enzyme	PYGM	-	20000	-	-
reviewed	BXGT006925	Glycogen phosphorylase, liver form	reviewed		Pygl	-	101000	-	-
reviewed	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	reviewed		PTPN1	-	7000	-	-

CHEMBL

CHEMBL391533

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P29350	BXGT009335	Tyrosine-protein phosphatase non-receptor type 6	reviewed	-	PTPN6	IC50	'='	24560	nM
P00489	BXGT005553	Glycogen phosphorylase, muscle form	reviewed	-	PYGM	IC50	'='	20000	nM
P23469	BXGT008871	Receptor-type tyrosine-protein phosphatase epsilon	reviewed	Enzyme	PTPRE	IC50	'>'	40000	nM
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	reviewed	-	ATAD5	Potency	-	23109	nM
P00489	BXGT005553	Glycogen phosphorylase, muscle form	reviewed	-	PYGM	IC50	'='	19952	nM
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	Km	'='	2	mg/ml
P42858	BXGT010341	Huntingtin	reviewed	-	HTT	Potency	'='	12589	nM
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	reviewed	-	PTPN1	IC50	'='	5490	nM
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	35481	nM
P10520	BXGT007576	Streptokinase A	reviewed	-	ska	EC50	'='	2813	nM
P10586	BXGT007581	Receptor-type tyrosine-protein phosphatase F	reviewed	Enzyme	PTPRF	IC50	'>'	40000	nM
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	reviewed	-	HSD11B1	Inhibition	-	-	-
Q96QE3	BXGT019718	ATPase family AAA domain-containing protein 5	reviewed	-	ATAD5	Potency	-	32642	nM
P17706	BXGT008330	Tyrosine-protein phosphatase non-receptor type 2	reviewed	-	PTPN2	IC50	'='	11310	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	16360	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	29092	nM
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	reviewed	-	HSD11B1	IC50	'='	810	nM
P19357	BXGT008475	Solute carrier family 2, facilitated glucose transporter member 4	reviewed	-	Slc2a4	FC	'='	1	-
P06746	BXGT006496	DNA polymerase beta	reviewed	Enzyme	POLB	IC50	'='	12600	nM
P11217	BXGT007674	Glycogen phosphorylase, muscle form	reviewed	Enzyme	PYGM	IC50	'='	20000	nM
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	10000	nM
P18433	BXGT008403	Receptor-type tyrosine-protein phosphatase alpha	reviewed	Enzyme	PTPRA	IC50	'>'	40000	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	12995	nM
P09811	BXGT006925	Glycogen phosphorylase, liver form	reviewed	-	Pygl	IC50	'='	101000	nM
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	reviewed	Enzyme	NFE2L2	Potency	-	16360	nM
Q99700	BXGT019949	Ataxin-2	reviewed	Nucleic acid binding	ATXN2	Potency	-	39810	nM
P80365	BXGT011895	Corticosteroid 11-beta-dehydrogenase isozyme 2	reviewed	Enzyme	HSD11B2	Inhibition	-	-	-
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	Vmax	'='	21	ug/ml/min
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	89125	nM
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	reviewed	Transcription factor	SMAD3	Potency	-	35481	nM
Q8WZA2	BXGT019025	Rap guanine nucleotide exchange factor 4	reviewed	Enzyme modulator	RAPGEF4	Potency	-	89125	nM
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	reviewed	-	PTPN1	IC50	'='	7000	nM
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	Kis	'='	25	uM
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	IC50	'='	31200	nM
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	Km	'='	2	mg/ml
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	Kii	'='	28	uM
P00690	BXGT005612	Pancreatic alpha-amylase	reviewed	-	AMY2	Vmax	'='	14	ug/ml/min

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00076	Loquat	Eriobotrya japonica	Fruits
BXGF00162	Red raspberry	Rubus idaeus	Fruits
BXGF00910	Glechoma longituba	Glechoma longituba	Medicinal Plant
BXGF00940	Prunus cerasoides	Prunus cerasoides	Medicinal Plant
BXGF00959	Artemisia hanseniana	Artemisia hanseniana	Others
BXGF01074	Centella asiatica	Centella asiatica	Medicinal Plant
BXGF01091	Rubus alceifolius	Rubus alceifolius	Human Edible Plant
BXGF01109	Styrax benzoin	Styrax benzoin	Medicinal Plant
BXGF01138	Tulipa sylvestris	Tulipa sylvestris	Human Edible Plant
BXGF01159	Kopsia grandifolia	Kopsia grandifolia	Others
BXGF01281	Ledebouria socialis	Ledebouria socialis	Others
BXGF01317	Acer pictum subsp. okamotoanum	Acer pictum subsp. okamotoanum	Medicinal Plant
BXGF01338	Amsinckia menziesii	Amsinckia menziesii	Others
BXGF01361	Lycopus europaeus	Lycopus europaeus	Medicinal Plant
BXGF01380	Cneorum pulverulentum	Cneorum pulverulentum	Medicinal Plant
BXGF01383	Dipodium punctatum	Dipodium punctatum	Others
BXGF01400	Dipterocarpus dyeri	Dipterocarpus dyeri	Others
BXGF01426	Cornus officinalis	Cornus officinalis	Medicinal Plant
BXGF01481	Glycine falcata	Glycine falcata	Others
BXGF01487	Styrax tonkinensis	Styrax tonkinensis	Medicinal Plant
BXGF01518	Ipomoea cairica	Ipomoea cairica	Medicinal Plant
BXGF01616	Senecio fuertesii	Senecio fuertesii	Others
BXGF01642	Pyrola japonica	Pyrola japonica	Medicinal Plant
BXGF01693	Psittacanthus cucullaris	Psittacanthus cucullaris	Others
BXGF01699	Ceanothus velutinus	Ceanothus velutinus	Medicinal Plant
BXGF01701	Polygala amarella	Polygala amarella	Medicinal Plant
BXGF01712	Aspilia hispida	Aspilia hispida	Others
BXGF01732	Garcinia scortechinii	Garcinia scortechinii	Others
BXGF01756	Apollonias barbujana	Apollonias barbujana	Others
BXGF01770	Clutia richardiana	Clutia richardiana	Others
BXGF01781	Chlorophytum borivilianum	Chlorophytum borivilianum	Medicinal Plant
BXGF01785	Campsis radicans	Campsis radicans	Medicinal Plant
BXGF01798	Melaleuca uncinata	Melaleuca uncinata	Others
BXGF01800	Salvia palaestina	Salvia palaestina	Others
BXGF01833	Hakea saligna	Hakea saligna	Others
BXGF01853	Ilex pubescens	Ilex pubescens	Others
BXGF01856	Aquilaria sinensis	Aquilaria sinensis	Medicinal Plant
BXGF01868	Vitex negundo	Vitex negundo	Medicinal Plant
BXGF01922	Senecio nemorensis	Senecio nemorensis	Medicinal Plant
BXGF01940	Salvia trijuga	Salvia trijuga	Medicinal Plant
BXGF01959	Cissus quinquefolia	Cissus quinquefolia	Others
BXGF02011	Boswellia carterii	Boswellia carterii	Medicinal Plant
BXGF02061	Dracocephalum kotschyi	Dracocephalum kotschyi	Medicinal Plant
BXGF02164	Isodon japonica var. glaucocalyx	Isodon japonica var. glaucocalyx	Others
BXGF02307	Diospyros verrucosa	Diospyros verrucosa	Human Edible Plant
BXGF02316	Isodon lophanthoides	Isodon lophanthoides	Medicinal Plant
BXGF02384	Verbesina virgata	Verbesina virgata	Others
BXGF02398	Dalea versicolor	Dalea versicolor	Others
BXGF02452	Alstonia yunnanensis	Alstonia yunnanensis	Medicinal Plant
BXGF02552	Sideritis cystosiphon	Sideritis cystosiphon	Others
BXGF02553	Avrainvillea nigricans	Avrainvillea nigricans	Others
BXGF02596	Fragaria vesca	Fragaria vesca	Medicinal Plant
BXGF02604	Agrimonia pilosa	Agrimonia pilosa	Medicinal Plant
BXGF02611	Geranium nepalense	Geranium nepalense	Medicinal Plant
BXGF02612	Mosla chinensis	Mosla chinensis	Medicinal Plant
BXGF02614	Isodon adenolomus	Isodon adenolomus	Others
BXGF02639	Rhododendron ferrugineum	Rhododendron ferrugineum	Human Edible Plant
BXGF02668	Stachys tuberifera	Stachys tuberifera	Medicinal Plant
BXGF02683	Tylophora atrofolliculata	Tylophora atrofolliculata	Medicinal Plant
BXGF02711	Ligularia dentata	Ligularia dentata	Medicinal Plant
BXGF02713	Drypetes roxburghii	Drypetes roxburghii	Medicinal Plant
BXGF02719	Achyrocline bogotensis	Achyrocline bogotensis	Others
BXGF02825	Buddleja variabilis	Buddleja variabilis	Others
BXGF02842	Euphorbia franckiana	Euphorbia franckiana	Others
BXGF02865	Dasymaschalon blumei	Dasymaschalon blumei	Others
BXGF02910	Chamaemelum fuscatum	Chamaemelum fuscatum	Others
BXGF02926	Scutellaria albida	Scutellaria albida	Medicinal Plant
BXGF02937	Senecio scandens	Senecio scandens	Medicinal Plant
BXGF02998	Uncaria gambier	Uncaria gambier	Medicinal Plant
BXGF03001	Vallaris solanacea	Vallaris solanacea	Medicinal Plant
BXGF03048	Campsis grandiflora	Campsis grandiflora	Medicinal Plant
BXGF03065	Mentha pulegiformis	Mentha pulegiformis	Others
BXGF03072	Athanasia crithmifolia	Athanasia crithmifolia	Others
BXGF03090	Lasianthus fordii	Lasianthus fordii	Others
BXGF03096	Salvia nubicola	Salvia nubicola	Human Edible Plant
BXGF03125	Grindelia nana	Grindelia nana	Others
BXGF03164	Patrinia scabiosifolia	Patrinia scabiosifolia	Medicinal Plant
BXGF03170	Haloxylon salicornicum	Haloxylon salicornicum	Medicinal Plant
BXGF03229	Leucanthemum maximum	Leucanthemum maximum	Others
BXGF03243	Elsholtzia ciliata	Elsholtzia ciliata	Medicinal Plant
BXGF03249	Vitex trifolia	Vitex trifolia	Medicinal Plant
BXGF03281	Calea megacephala	Calea megacephala	Others
BXGF03323	Abies nobilis	Abies nobilis	Others
BXGF03345	Persea indica	Persea indica	Medicinal Plant
BXGF03369	Corydalis cornuta	Corydalis cornuta	Others
BXGF03401	Disepalum plagioneurum	Disepalum plagioneurum	Others
BXGF03412	Perovskia abrotanoides	Perovskia abrotanoides	Medicinal Plant
BXGF03418	Piper aequale	Piper aequale	Medicinal Plant
BXGF03430	Alkanna hirsutissima	Alkanna hirsutissima	Others
BXGF03448	Pinus picea	Pinus picea	Others
BXGF03466	Picris radicata	Picris radicata	Others
BXGF03471	Kippistia suaedifolia	Kippistia suaedifolia	Others
BXGF03525	Acrocomia sclerocarpa	Acrocomia sclerocarpa	Others
BXGF03539	Picradeniopsis pringlei	Picradeniopsis pringlei	Others
BXGF03540	Eremophila serrulata	Eremophila serrulata	Others
BXGF03550	Rodgersia podophylla	Rodgersia podophylla	Medicinal Plant
BXGF03566	Delphinium campylocentrum	Delphinium campylocentrum	Others
BXGF03574	Cordyline indivisa	Cordyline indivisa	Medicinal Plant
BXGF03588	Primula hirsuta	Primula hirsuta	Others
BXGF03604	Jasminum grandiflorum	Jasminum grandiflorum	Medicinal Plant
BXGF03611	Viscum coloratum	Viscum coloratum	Medicinal Plant
BXGF03635	Hertia intermedia	Hertia intermedia	Others
BXGF03718	Swertia angustifolia	Swertia angustifolia	Medicinal Plant
BXGF03767	Pelargonium reniforme	Pelargonium reniforme	Medicinal Plant
BXGF03824	Haplopappus ciliatus	Haplopappus ciliatus	Others
BXGF04049	Symplocos lancifolia	Symplocos lancifolia	Others
BXGF04076	Tetraneuris acaulis	Tetraneuris acaulis	Others
BXGF04095	Buddleja scordioides	Buddleja scordioides	Others
BXGF04122	Glechoma grandis	Glechoma grandis	Medicinal Plant
BXGF04196	Fagus crenata	Fagus crenata	Medicinal Plant
BXGF04204	Viburnum ayavacense	Viburnum ayavacense	Others
BXGF04266	Artemisia umbelliformis	Artemisia umbelliformis	Medicinal Plant
BXGF04278	Casimiroa tetrameria	Casimiroa tetrameria	Medicinal Plant
BXGF04370	Monochaetum vulcanicum	Monochaetum vulcanicum	Others
BXGF04385	Vatica cinerea	Vatica cinerea	Others
BXGF04522	Cardamine pinnata	Cardamine pinnata	Others
BXGF04524	Codonocarpus australis	Codonocarpus australis	Others
BXGF04531	Schizonepeta multifida	Schizonepeta multifida	Others
BXGF04536	Acer triflorum	Acer triflorum	Others
BXGF04537	Swertia japonica	Swertia japonica	Medicinal Plant
BXGF04546	Quercus serrata	Quercus serrata	Medicinal Plant
BXGF04551	Crateva nurvala	Crateva nurvala	Human Edible Plant
BXGF04567	Polygala amara	Polygala amara	Medicinal Plant
BXGF04574	Stephania sutchuenensis	Stephania sutchuenensis	Others
BXGF04583	Unonopsis glaucopetala	Unonopsis glaucopetala	Others
BXGF04609	Rubus rosa	Rubus rosa	Medicinal Plant
BXGF04616	Pleogyne cunninghamii	Pleogyne cunninghamii	Others
BXGF04626	Pyrola decorata	Pyrola decorata	Medicinal Plant
BXGF04633	Pleogyne cunninghami	Pleogyne cunninghami	Others
BXGF04639	Euonymus nanoides	Euonymus nanoides	Others
BXGF04667	Cerbera dilatata	Cerbera dilatata	Others
BXGF04674	Achillea clypeolata	Achillea clypeolata	Others
BXGF04679	Bridelia ferruginea	Bridelia ferruginea	Medicinal Plant
BXGF04692	Berberis julianae	Berberis julianae	Medicinal Plant
BXGF04695	Zieria smithii	Zieria smithii	Others
BXGF04701	Bystropogon origanifolius	Bystropogon origanifolius	Others
BXGF04998	Rhododendron brachycarpum	Rhododendron brachycarpum	Medicinal Plant
BXGF05039	Cynanchum auriculatum	Cynanchum auriculatum	Human Edible Plant
BXGF05057	Helichrysum nitens	Helichrysum nitens	Others
BXGF05096	Aconitum leucostomum	Aconitum leucostomum	Medicinal Plant
BXGF05118	Euscaphis japonica	Euscaphis japonica	Medicinal Plant
BXGF05142	Salix japonica	Salix japonica	Medicinal Plant
BXGF05169	Senecio sinuatus	Senecio sinuatus	Others
BXGF05200	Aquilegia ecalcarata	Aquilegia ecalcarata	Medicinal Plant
BXGF05218	Hedysarum multijugum	Hedysarum multijugum	Medicinal Plant
BXGF05238	Drimia sanguinea	Drimia sanguinea	Medicinal Plant
BXGF05281	Fritillaria thunbergii	Fritillaria thunbergii	Medicinal Plant
BXGF05305	Alangium ridleyi	Alangium ridleyi	Human Edible Plant
BXGF05310	Onopordum anatolicum	Onopordum anatolicum	Medicinal Plant
BXGF05313	Hedysarum denticulatum	Hedysarum denticulatum	Others
BXGF05316	Persea mexicana	Persea mexicana	Others
BXGF05340	Adiantum caudatum	Adiantum caudatum	Medicinal Plant
BXGF05345	Phlomis umbrosa	Phlomis umbrosa	Medicinal Plant
BXGF05348	Colchicum speciosum	Colchicum speciosum	Others
BXGF05355	Plectranthus sylvestris	Plectranthus sylvestris	Medicinal Plant
BXGF05375	Salvia cana	Salvia cana	Others
BXGF05448	Dryopteris crassirhizoma	Dryopteris crassirhizoma	Medicinal Plant
BXGF05460	Bryum weigelii	Bryum weigelii	Others
BXGF05462	Campsis flos	Campsis flos	Others
BXGF05531	Relbunium atherodes	Relbunium atherodes	Others
BXGF05534	Walsura chrysogyne	Walsura chrysogyne	Others
BXGF05539	Ligularia songarica	Ligularia songarica	Others
BXGF05563	Phegopteris bukoensis	Phegopteris bukoensis	Others
BXGF05571	Ziziphus jujuba	Ziziphus jujuba	Medicinal Plant
BXGF05621	Agathosma thymifolia	Agathosma thymifolia	Others
BXGF05625	Jacobaea subalpina	Jacobaea subalpina	Others
BXGF05649	Phlomis regelii	Phlomis regelii	Others
BXGF05663	Juglans sinensis	Juglans sinensis	Medicinal Plant
BXGF05754	Dalea purpurea	Dalea purpurea	Medicinal Plant
BXGF05767	Gardenia tubifera	Gardenia tubifera	Medicinal Plant
BXGF05784	Zaluzianskya capensis	Zaluzianskya capensis	Others
BXGF05787	Smilax glabra	Smilax glabra	Medicinal Plant
BXGF05831	Rosa laevigata	Rosa laevigata	Medicinal Plant
BXGF05845	Panax innovans	Panax innovans	Others
BXGF05921	Scapania nemorea	Scapania nemorea	Others
BXGF05937	Diphasiastrum alpinum	Diphasiastrum alpinum	Others
BXGF05953	Bryum rutilans	Bryum rutilans	Others
BXGF05956	Blumea mollis	Blumea mollis	Medicinal Plant
BXGF05977	Schisandra chinensis	Schisandra chinensis	Medicinal Plant
BXGF06070	Perilla frutescens	Perilla frutescens	Medicinal Plant
BXGF06184	Plantago cornuti	Plantago cornuti	Medicinal Plant
BXGF06213	Heliomeris multiflora	Heliomeris multiflora	Others
BXGF06220	Tiliacora triandra	Tiliacora triandra	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}