Showing entry for Receptor-type tyrosine-protein phosphatase F


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007581
Protein NameReceptor-type tyrosine-protein phosphatase F
Uniport IdP10586
GenePTPRF
Gene Id5792
Domainfn3; I-set; Y_phosphatase
Pfam PF00041   PF07679   PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:1900121 negative regulation of receptor binding
Biological Process GO:0031102 neuron projection regeneration
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0048679 regulation of axon regeneration
Biological Process GO:0099560 synaptic membrane adhesion
Biological Process GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0035373 chondroitin sulfate proteoglycan binding
molecular function GO:0008201 heparin binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-8849932 Synaptic adhesion-like molecules
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001206 BXGD000033 Acromegaly Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0009376 BXGD000603 Colonic Polyps Pathological Conditions, Signs and Symptoms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018979 BXGD001260 Hemianopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0020514 BXGD001414 Hyperprolactinemia Nervous System Diseases; Endocrine System Diseases
C0021167 BXGD001487 Incontinence Nervous System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024586 BXGD001787 Malignant Carcinoid Syndrome Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0033375 BXGD002405 Prolactinoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038586 BXGD002772 Substance Use Disorders Chemically-Induced Disorders; Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0079218 BXGD003066 Fibromatosis, Aggressive Neoplasms
C0085411 BXGD003169 Angiodysplasia Cardiovascular Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0175755 BXGD004016 Congenital absent nipple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0202239 BXGD004087 Uric acid measurement (procedure)
C0206093 BXGD004154 Neuroectodermal Tumors Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0332853 BXGD006901 Anastomosis
C0344453 BXGD007672 Macroprolactinoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346302 BXGD007807 Growth Hormone-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0346303 BXGD007808 Thyrotroph adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410005 BXGD008407 Nodular fasciitis Neoplasms; Musculoskeletal Diseases; Nervous System Diseases
C0425795 BXGD008553 Absent nipple (finding)
C0426429 BXGD008564 Broad nasal tip
C0432355 BXGD008780 Hypoplasia of nipple
C0432357 BXGD008781 Congenital absence of breast with absent nipple Skin and Connective Tissue Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0752149 BXGD010678 Headache, Intractable Nervous System Diseases
C1142533 BXGD011758 Smooth philtrum
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1519678 BXGD013243 Tumor Expansion
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1842680 BXGD014529 Small earlobe
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3160814 BXGD018477 Cannabis use
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4014918 BXGD020171 BREASTS AND/OR NIPPLES, APLASIA OR HYPOPLASIA OF, 2
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4723838 BXGD023809 Metastatic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0006466 Oleanolic acid 456.71
BXGC0013003 lipidyl pseudopterane A 626.38
BXGC0014385 1,2,3,4,6-Penta-O-Galloyl-D-Glucopyranose 940.12
BXGC0023586 Morolic Acid 456.36
BXGC0026592 Bruguiesulfurol 153.98
BXGC0027621 (3Beta,24R)-Stigmasta-5,28-Diene-3,24-Diol 428.37
BXGC0030612 tetraethylene glycol 194.12
BXGC0032040 (3Beta,24S)-Stigmasta-5,28-Diene-3,24-Diol 428.37
BXGC0035976 Trans-Phytol 296.31
BXGC0035993 n.a 462.37
BXGC0042728 3beta-Hydroxycholesta-5,22-diene-24-one 398.32
BXGC0045407 n.a 461.35
BXGC0045408 (23e)-3beta-hydroxystigmasta-5,23-dien-28-one 426.35
BXGC0047088 Ursolic Acid 456.36
BXGC0048386 Alpha-Tocoquinone 446.38
BXGC0049477 Moronic Acid 454.34
BXGC0049758 Corosolic Acid 472.36
BXGC0050651 Cryptotanshinone 296.14
BXGC0051666 Maslinic Acid 472.36
BXGC0053458 Phytyl acetate 338.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein