protein

Showing entry for Corticosteroid 11-beta-dehydrogenase isozyme 1

General Target Information
BXGT Id	BXGT009297
Protein Name	Corticosteroid 11-beta-dehydrogenase isozyme 1
Uniport Id	P28845
Gene	HSD11B1
Gene Id	3290
Domain	adh_short
Pfam	PF00106
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.3 Lipid metabolism	hsa00140	Steroid hormone biosynthesis
1. Metabolism	1.11 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways
6. Human Diseases	6.1 Cancers: Overview	hsa05204	Chemical carcinogenesis

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006704	glucocorticoid biosynthetic process
Biological Process	GO:0030324	lung development
Biological Process	GO:0006706	steroid catabolic process
molecular function	GO:0070524	11-beta-hydroxysteroid dehydrogenase (NADP+) activity
molecular function	GO:0050661	NADP binding
molecular function	GO:0042803	protein homodimerization activity
molecular function	GO:0005496	steroid binding
cellular component	GO:0005789	endoplasmic reticulum membrane
cellular component	GO:0030176	integral component of endoplasmic reticulum membrane
cellular component	GO:0016020	membrane
molecular function	GO:0003845	11-beta-hydroxysteroid dehydrogenase NAD(P) activity

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-194002	Glucocorticoid biosynthesis
R-HSA-196071	Metabolism of steroid hormones
R-HSA-556833	Metabolism of lipids
R-HSA-8957322	Metabolism of steroids

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0001206	BXGD000033	Acromegaly	Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0001403	BXGD000048	Addison Disease	Immune System Diseases; Endocrine System Diseases
C0001418	BXGD000050	Adenocarcinoma	Neoplasms
C0001430	BXGD000054	Adenoma	Neoplasms
C0001622	BXGD000065	Adrenal Gland Hyperfunction	Endocrine System Diseases
C0001624	BXGD000067	Adrenal Gland Neoplasms	Neoplasms; Endocrine System Diseases
C0001787	BXGD000076	Osteoporosis, Age-Related	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0002152	BXGD000104	Alloxan Diabetes	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002170	BXGD000105	Alopecia	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002622	BXGD000119	Amnesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002726	BXGD000125	Amyloidosis	Nutritional and Metabolic Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004936	BXGD000295	Mental disorders	Mental Disorders
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007114	BXGD000431	Malignant neoplasm of skin	Neoplasms; Skin and Connective Tissue Diseases
C0007120	BXGD000435	Bronchioloalveolar Adenocarcinoma	Neoplasms
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009404	BXGD000606	Colorectal Neoplasms	Digestive System Diseases; Neoplasms
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0010276	BXGD000659	Craniopharyngioma	Neoplasms
C0010278	BXGD000660	Craniosynostosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010481	BXGD000673	Cushing Syndrome	Endocrine System Diseases
C0011265	BXGD000708	Presenile dementia	Nervous System Diseases; Mental Disorders
C0011570	BXGD000729	Mental Depression	Behavior and Behavior Mechanisms
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011615	BXGD000738	Dermatitis, Atopic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853	BXGD000752	Diabetes Mellitus, Experimental	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013595	BXGD000858	Eczema	Skin and Connective Tissue Diseases
C0015695	BXGD001013	Fatty Liver	Digestive System Diseases
C0016053	BXGD001041	Fibromyalgia	Musculoskeletal Diseases; Nervous System Diseases
C0017601	BXGD001125	Glaucoma	Eye Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0020456	BXGD001392	Hyperglycemia	Nutritional and Metabolic Diseases
C0020459	BXGD001394	Hyperinsulinism	Nutritional and Metabolic Diseases
C0020473	BXGD001396	Hyperlipidemia	Nutritional and Metabolic Diseases
C0020476	BXGD001398	Hyperlipoproteinemias	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0021655	BXGD001508	Insulin Resistance	Nutritional and Metabolic Diseases
C0022104	BXGD001529	Irritable Bowel Syndrome	Digestive System Diseases
C0022661	BXGD001572	Kidney Failure, Chronic	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024117	BXGD001734	Chronic Obstructive Airway Disease	Respiratory Tract Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024530	BXGD001783	Malaria	Infections
C0025202	BXGD001832	melanoma	Neoplasms
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027121	BXGD001973	Myositis	Musculoskeletal Diseases; Nervous System Diseases
C0027430	BXGD001988	Nasal Polyps	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0029453	BXGD002154	Osteopenia	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456	BXGD002157	Osteoporosis	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459	BXGD002159	Osteoporosis, Senile	Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463	BXGD002160	Osteosarcoma	Neoplasms
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0032227	BXGD002336	Pleural effusion disorder	Respiratory Tract Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0037274	BXGD002676	Dermatologic disorders	Skin and Connective Tissue Diseases
C0038220	BXGD002740	Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038433	BXGD002754	Streptozotocin Diabetes	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0038443	BXGD002757	Stress, Psychological	Behavior and Behavior Mechanisms
C0039103	BXGD002791	Synovitis	Musculoskeletal Diseases
C0041326	BXGD002915	Pleural Tuberculosis	Infections; Respiratory Tract Diseases
C0041327	BXGD002916	Tuberculosis, Pulmonary	Infections; Respiratory Tract Diseases
C0042842	BXGD003005	Vitamin A Deficiency	Nutritional and Metabolic Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085580	BXGD003191	Essential Hypertension	Cardiovascular Diseases
C0149516	BXGD003324	Chronic sinusitis	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0149721	BXGD003349	Left Ventricular Hypertrophy	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151718	BXGD003464	Hypocholesterolemia	Nutritional and Metabolic Diseases
C0162309	BXGD003934	Adrenoleukodystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162820	BXGD003985	Dermatitis, Allergic Contact	Skin and Connective Tissue Diseases; Immune System Diseases
C0206081	BXGD004152	Hyperandrogenism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0221074	BXGD004388	Depression, Postpartum	Female Urogenital Diseases and Pregnancy Complications; Mental Disorders
C0221406	BXGD004459	Pituitary-dependent Cushing's disease	Nervous System Diseases; Endocrine System Diseases
C0233514	BXGD004584	Abnormal behavior	Behavior and Behavior Mechanisms
C0233794	BXGD004618	Memory impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234985	BXGD004708	Mental deterioration	Mental Disorders
C0238052	BXGD004866	Xanthomatosis, Cerebrotendinous	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0238198	BXGD004893	Gastrointestinal Stromal Tumors	Digestive System Diseases; Neoplasms
C0242339	BXGD005150	Dyslipidemias	Nutritional and Metabolic Diseases
C0242383	BXGD005160	Age related macular degeneration	Eye Diseases
C0242723	BXGD005193	Parasitemia	Pathological Conditions, Signs and Symptoms; Infections
C0263678	BXGD005343	Acute arthritis	Musculoskeletal Diseases
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0271885	BXGD006276	Hypothalamic obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0278652	BXGD006554	Childhood Craniopharyngioma	Neoplasms
C0278875	BXGD006606	Adult Craniopharyngioma	Neoplasms
C0311277	BXGD006874	Obesity, Abdominal	Nutritional and Metabolic Diseases
C0312414	BXGD006886	Menstrual spotting
C0333516	BXGD006957	Tumor necrosis	Pathological Conditions, Signs and Symptoms
C0338078	BXGD007166	Non-Functioning Pituitary Gland Neoplasm	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0338657	BXGD007212	Age-associated memory impairment
C0338908	BXGD007218	Mixed anxiety and depressive disorder	Mental Disorders
C0342335	BXGD007461	insulin resistance in diabetes	Nutritional and Metabolic Diseases
C0342443	BXGD007481	Adrenal Cushing's syndrome	Endocrine System Diseases
C0342488	BXGD007488	Mineralocorticoid Excess Syndrome, Apparent	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0344315	BXGD007666	Depressed mood	Behavior and Behavior Mechanisms
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0473527	BXGD008939	Hypoalphalipoproteinemias	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0494463	BXGD009029	Alzheimer Disease, Late Onset	Nervous System Diseases; Mental Disorders
C0497327	BXGD009061	Dementia	Nervous System Diseases; Mental Disorders
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0598608	BXGD009668	Hyperhomocysteinemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0747845	BXGD010184	early pregnancy
C0751295	BXGD010383	Memory Loss	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0849640	BXGD010889	skin damage
C0852036	BXGD010934	Pregnancy associated hypertension	Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0853897	BXGD010985	Diabetic Cardiomyopathies	Endocrine System Diseases; Cardiovascular Diseases
C0872084	BXGD011319	Sarcopenia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0877008	BXGD011325	Enzyme inhibition disorder
C0920563	BXGD011469	Insulin Sensitivity	Nutritional and Metabolic Diseases
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1290886	BXGD012200	Chronic inflammatory disorder	Pathological Conditions, Signs and Symptoms
C1291245	BXGD012205	Cortisone reductase deficiency	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Endocrine System Diseases
C1306214	BXGD012356	ACTH-Secreting Pituitary Adenoma	Neoplasms; Nervous System Diseases; Endocrine System Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1332986	BXGD012574	Childhood Osteosarcoma	Neoplasms
C1392786	BXGD012978	Cognitive changes	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1397307	BXGD012996	Cardiac fibrosis
C1735378	BXGD013710	Chronic polyarthritis
C1842981	BXGD014547	NEUROTICISM	Behavior and Behavior Mechanisms
C1855520	BXGD015506	Hyperglycemia, Postprandial	Nutritional and Metabolic Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2316810	BXGD017030	Chronic kidney disease stage 5	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2362324	BXGD017091	Pediatric Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2717865	BXGD017513	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	Immune System Diseases; Cardiovascular Diseases
C2936179	BXGD018103	Obesity, Visceral	Nutritional and Metabolic Diseases
C3489532	BXGD018934	Cone-Rod Dystrophy 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3553382	BXGD019172	CORTISONE REDUCTASE DEFICIENCY 2
C3714636	BXGD019421	Pneumonitis	Infections; Respiratory Tract Diseases
C3887949	BXGD019932	Apparent mineralocorticoid excess	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4268741	BXGD022327	Age-related sarcopenia
C4329210	BXGD022782	11-Beta-Hydroxysteroid Dehydrogenase Type 1 Deficiency
C4524092	BXGD023092	Chronic rhinosinusitis with nasal polyps
C4529962	BXGD023178	Fatty Liver Disease
C4551552	BXGD023346	Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000436	Glycerol		92.09
BXGC0000578	Herniarin		176.17
BXGC0000681	Umbelliferone		162.14
BXGC0003426	(-)-Kaur-16-en-19-oic acid		302.46
BXGC0003705	Chloride		35.45
BXGC0003776	Flavones		222.24
BXGC0005683	Quercetin		302.24
BXGC0008219	11-Keto-beta-boswellic acid		470.68
BXGC0011627	Glycyrrhetic acid		470.69
BXGC0013582	Curcumin		368.13
BXGC0017345	Maslinic Acid Methyl Ester		486.37
BXGC0020601	3-O-cis-p-coumaroyltormentic acid		634.39
BXGC0024810	curcumin		368.13
BXGC0026595	Glycyrrhizin		822.4
BXGC0029810	1,5-Bis(4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadien-3-One		326.12
BXGC0033922	Mauritine A		575.31
BXGC0033947	3-O-trans-p-coumaroyltormentic acid		634.39
BXGC0034601	Tomentic Acid		488.35
BXGC0034610	Tormentic Acid Methyl Ester		502.37
BXGC0035197	Acetyl-11-Keto-Beta-Boswellic Acid		512.35
BXGC0039114	n.a		470.34
BXGC0041271	Corosolic Acid Methyl Ester		486.37
BXGC0043670	Uvaol		442.38
BXGC0047088	Ursolic Acid		456.36
BXGC0049758	Corosolic Acid		472.36
BXGC0050317	Acetoxolone		512.35
BXGC0050329	3-Epicorosolic Acid Methyl Ester		486.37

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}