Showing entry for Tyrosine-protein phosphatase non-receptor type 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008330
Protein NameTyrosine-protein phosphatase non-receptor type 2
Uniport IdP17706
GenePTPN2
Gene Id5771
DomainY_phosphatase
Pfam PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:0030218 erythrocyte differentiation
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0050922 negative regulation of chemotaxis
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
Biological Process GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
Biological Process GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
Biological Process GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
Biological Process GO:0010888 negative regulation of lipid storage
Biological Process GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
Biological Process GO:0045650 negative regulation of macrophage differentiation
Biological Process GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Biological Process GO:1902233 negative regulation of positive thymic T cell selection
Biological Process GO:0061099 negative regulation of protein tyrosine kinase activity
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
Biological Process GO:0060339 negative regulation of type I interferon-mediated signaling pathway
Biological Process GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0045722 positive regulation of gluconeogenesis
Biological Process GO:1903899 positive regulation of PERK-mediated unfolded protein response
Biological Process GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
Biological Process GO:0060334 regulation of interferon-gamma-mediated signaling pathway
Biological Process GO:0030217 T cell differentiation
molecular function GO:0005178 integrin binding
molecular function GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0097677 STAT family protein binding
molecular function GO:0019905 syntaxin binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-446652 Interleukin-1 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-6806834 Signaling by MET
R-HSA-6807004 Negative regulation of MET activity
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9008059 Interleukin-37 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003635 BXGD000214 Apraxias Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013537 BXGD000853 Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0014772 BXGD000948 Red Blood Cell Count measurement
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022073 BXGD001525 Iridocyclitis Eye Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023492 BXGD001671 Leukemia, T-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024266 BXGD001754 Lymphocytic Choriomeningitis Infections; Nervous System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026918 BXGD001948 Mycobacterium Infections Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031046 BXGD002275 Pericarditis Cardiovascular Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0087031 BXGD003319 Juvenile-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0151480 BXGD003426 Anti-nuclear factor positive Skin and Connective Tissue Diseases
C0151632 BXGD003450 ESR raised
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152031 BXGD003524 Joint swelling Pathological Conditions, Signs and Symptoms
C0153014 BXGD003612 Non-arthropod borne lymphocytic choriomeningitis Infections; Nervous System Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0162323 BXGD003937 Polyarthritis Musculoskeletal Diseases
C0162538 BXGD003954 Immunoglobulin A deficiency (disorder) Immune System Diseases; Hemic and Lymphatic Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0201657 BXGD004051 C-reactive protein measurement
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0267380 BXGD005743 Crohn's disease of the ileum Digestive System Diseases
C0275524 BXGD006376 Coinfection Infections
C0278486 BXGD006513 Breast cancer stage II
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678202 BXGD009747 Regional enteritis Digestive System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0949272 BXGD011573 IIeocolitis Digestive System Diseases
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1384600 BXGD012945 Systemic onset juvenile chronic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519346 BXGD013235 Skin Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1857108 BXGD015677 Limitation of joint mobility
C1858558 BXGD015806 Rheumatoid Arthritis, Systemic Juvenile Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931171 BXGD017967 Juvenile pauciarticular chronic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3150797 BXGD018337 AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
C3160909 BXGD018497 Autoimmune arthritis
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3495798 BXGD019003 Periodontal inflammation
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3665419 BXGD019285 intracranial glioma Neoplasms; Nervous System Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3890205 BXGD020020 Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3898105 BXGD020059 Oligoarticular Juvenile Idiopathic Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4014795 BXGD020166 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
C4023452 BXGD021191 Elevated C-reactive protein level
C4049006 BXGD021912 Selective immunoglobulin A deficiency
C4310768 BXGD022658 AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
C4331504 BXGD022814 Vitamin D Dependent Rickets 2 Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C4520714 BXGD023034 Stage II Breast Cancer AJCC v6 and v7
C4528554 BXGD023163 Anatomic Stage II Breast Cancer AJCC v8
C4528580 BXGD023171 Prognostic Stage II Breast Cancer AJCC v8
C4529962 BXGD023178 Fatty Liver Disease
C4721209 BXGD023734 Metastatic human epidermal growth factor 2 positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001879 Chlorogenic acid 354.31
BXGC0003803 Oleanolic acid 3-acetate 498.75
BXGC0003997 3-Oxo-olean-12-en-28-oic acid 454.7
BXGC0005535 Licoagrone 742.81
BXGC0006466 Oleanolic acid 456.71
BXGC0007171 Licoagroaurone 338.35
BXGC0008219 11-Keto-beta-boswellic acid 470.68
BXGC0008469 3-Epioleanolic acid 456.7
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0012524 Erythrodiol 442.38
BXGC0012913 Pentagalloyl Glucose 940.12
BXGC0014385 1,2,3,4,6-Penta-O-Galloyl-D-Glucopyranose 940.12
BXGC0015729 (1Alpha,4Alpha,5Beta,10Beta)-4,5-Dihydroxy-7(11)-Guaien-8-One 252.17
BXGC0016006 5-Methoxycanthinone 250.07
BXGC0017212 Glycybenzofuran 354.15
BXGC0021441 Glisoflavone 368.13
BXGC0026592 Bruguiesulfurol 153.98
BXGC0027621 (3Beta,24R)-Stigmasta-5,28-Diene-3,24-Diol 428.37
BXGC0030981 n.a 456.36
BXGC0032040 (3Beta,24S)-Stigmasta-5,28-Diene-3,24-Diol 428.37
BXGC0032802 Methyl Oleanolate 470.38
BXGC0035122 Asiatic Acid 488.35
BXGC0035706 Oleanonic Acid 454.34
BXGC0035976 Trans-Phytol 296.31
BXGC0035993 n.a 462.37
BXGC0037407 Lithocholic Acid 376.3
BXGC0037549 Picrasidine L 250.07
BXGC0039611 Eurycomine E 280.08
BXGC0040349 Procurcumenol 234.16
BXGC0041001 Madecassic Acid 504.35
BXGC0041145 Augustic Acid 472.36
BXGC0042728 3beta-Hydroxycholesta-5,22-diene-24-one 398.32
BXGC0045069 Heyneanone A 268.17
BXGC0045071 Heyneanones C 268.17
BXGC0045407 n.a 461.35
BXGC0045408 (23e)-3beta-hydroxystigmasta-5,23-dien-28-one 426.35
BXGC0046524 (R)-5-Ethyl-3-Hexadecanoyl-4-Methyl-5H-Furan-2-Oneo 368.26
BXGC0047088 Ursolic Acid 456.36
BXGC0047138 3-Epimaslinic Acid 472.36
BXGC0048283 (E)-15,16-Bisnorlabda-8(17),11-Dien-13-One 260.21
BXGC0048386 Alpha-Tocoquinone 446.38
BXGC0049132 Aerugidiol 250.16
BXGC0049758 Corosolic Acid 472.36
BXGC0049929 Isobavachalcone 324.14
BXGC0050429 Zerumin A 318.22
BXGC0050651 Cryptotanshinone 296.14
BXGC0051666 Maslinic Acid 472.36
BXGC0051978 Boswellic Acid 456.36
BXGC0053458 Phytyl acetate 338.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein