Showing entry for Histone-binding protein RBBP4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013025
Protein NameHistone-binding protein RBBP4
Uniport IdQ09028
GeneRBBP4
Gene Id5928
DomainCAF1C_H4-bd; WD40
Pfam PF12265   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043044 ATP-dependent chromatin remodeling
Biological Process GO:0007049 cell cycle
Biological Process GO:0034080 CENP-A containing nucleosome assembly
Biological Process GO:0031497 chromatin assembly
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006260 DNA replication
Biological Process GO:0006335 DNA replication-dependent nucleosome assembly
Biological Process GO:0006336 DNA replication-independent nucleosome assembly
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0070317 negative regulation of G0 to G1 transition
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
molecular function GO:0042393 histone binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
cellular component GO:0033186 CAF-1 complex
cellular component GO:0005829 cytosol
cellular component GO:0035098 ESC/E(Z) complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016581 NuRD complex
cellular component GO:0016589 NURF complex
cellular component GO:0032991 protein-containing complex
cellular component GO:0016580 Sin3 complex
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266738 Developmental Biology
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-4839726 Chromatin organization
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5663205 Infectious disease
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-6807070 PTEN Regulation
R-HSA-6807070 PTEN Regulation
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69205 G1/S-Specific Transcription
R-HSA-69206 G1/S Transition
R-HSA-69242 S Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-73886 Chromosome Maintenance
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-774815 Nucleosome assembly
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029458 BXGD002158 Osteoporosis, Postmenopausal Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041341 BXGD002918 Tuberous Sclerosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0231341 BXGD004492 Premature aging syndrome Pathological Conditions, Signs and Symptoms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0853662 BXGD010975 Oestrogen deficiency
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2363741 BXGD017100 HIV-1 infection
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0004266 2-Propanol 60.1
BXGC0012404 Tanshindiol C 312.1
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein