Showing entry for High-Grade Squamous Intraepithelial Lesions


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD006972
Disease NameHigh-Grade Squamous Intraepithelial Lesions
Disease CUI IdC0333875
MeSH Codes C23   C04   C13  
Disease Class NamePathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O76054 BXGT005172 SEC14-like protein 2 23541 reviewed
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05546 BXGT006367 Heparin cofactor 2 3053 reviewed Enzyme modulator
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P25786 BXGT009068 Proteasome subunit alpha type-1 5682 reviewed
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29350 BXGT009335 Tyrosine-protein phosphatase non-receptor type 6 5777 reviewed
P29372 BXGT009336 DNA-3-methyladenine glycosylase 4350 reviewed Enzyme
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31151 BXGT009510 Protein S100-A7 6278 reviewed Calcium-binding protein
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P40261 BXGT010170 Nicotinamide N-methyltransferase 4837 reviewed Enzyme
P40967 BXGT010212 Melanocyte protein PMEL 6490 reviewed Signaling
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P43403 BXGT010385 Tyrosine-protein kinase ZAP-70 7535 reviewed Kinase
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P61088 BXGT011358 Ubiquitin-conjugating enzyme E2 N 7334 reviewed
P62266 BXGT011416 40S ribosomal protein S23 6228 reviewed Nucleic acid binding
P78396 BXGT011842 Cyclin-A1 8900 reviewed Enzyme modulator
Q13257 BXGT013333 Mitotic spindle assembly checkpoint protein MAD2A 4085 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q96GD0 BXGT019665 Pyridoxal phosphate phosphatase 57026 reviewed Enzyme
Q96T88 BXGT019747 E3 ubiquitin-protein ligase UHRF1 29128 reviewed
Q99933 BXGT019976 BAG family molecular chaperone regulator 1 573 reviewed
Q9BX66 BXGT020158 Sorbin and SH3 domain-containing protein 1 10580 reviewed
Q9UIQ6 BXGT021721 Leucyl-cystinyl aminopeptidase 4012 reviewed Enzyme
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
Q05086 BXGT025648 Ubiquitin-protein ligase E3A 7337 reviewed
Q9P2E7 BXGT025815 Protocadherin-10 57575 reviewed
P09471 BXGT026153 Guanine nucleotide-binding protein G(o) subunit alpha 2775 reviewed Enzyme modulator
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease