Showing entry for DNA-3-methyladenine glycosylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009336
Protein NameDNA-3-methyladenine glycosylase
Uniport IdP29372
GeneMPG
Gene Id4350
DomainPur_DNA_glyco
Pfam PF02245  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0045007 depurination
Biological Process GO:0006307 DNA dealkylation involved in DNA repair
molecular function GO:0003905 alkylbase DNA N-glycosylase activity
molecular function GO:0003684 damaged DNA binding
molecular function GO:0008725 DNA-3-methyladenine glycosylase activity
molecular function GO:0052822 DNA-3-methylguanine glycosylase activity
molecular function GO:0052821 DNA-7-methyladenine glycosylase activity
molecular function GO:0043916 DNA-7-methylguanine glycosylase activity
molecular function GO:0019104 DNA N-glycosylase activity
cellular component GO:0005829 cytosol
cellular component GO:0042645 mitochondrial nucleoid
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331 Cleavage of the damaged purine
R-HSA-110357 Displacement of DNA glycosylase by APEX1
R-HSA-73884 Base Excision Repair
R-HSA-73894 DNA Repair
R-HSA-73927 Depurination
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-73933 Resolution of Abasic Sites (AP sites)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008055 BXGD000514 Chikungunya Fever Infections
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021364 BXGD001500 Male infertility Male Urogenital Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022283 BXGD001533 Incontinentia Pigmenti Achromians Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0333875 BXGD006972 High-Grade Squamous Intraepithelial Lesions Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0343641 BXGD007636 Human papilloma virus infection Infections
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349458 BXGD007906 Cervical intraepithelial neoplasia grade 1 Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0851140 BXGD010916 Carcinoma in situ of uterine cervix Neoplasms
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1334274 BXGD012695 Invasive Carcinoma Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2752147 BXGD017769 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000340 Kaempferol 286.24
BXGC0000430 Gossypol 518.55
BXGC0001857 Caffeic acid 180.16
BXGC0002018 Morin 302.24
BXGC0002682 Zinc 65.41
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0005683 Quercetin 302.24
BXGC0006306 Myricetin 318.24
BXGC0023321 Quercetin Dihydrate 302.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein