Showing entry for Sorbin and SH3 domain-containing protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020158
Protein NameSorbin and SH3 domain-containing protein 1
Uniport IdQ9BX66
GeneSORBS1
Gene Id10580
DomainSH3_1; SH3_2; SH3_9; Sorb
Pfam PF00018   PF07653   PF14604   PF02208  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0006936 muscle contraction
Biological Process GO:0046326 positive regulation of glucose import
Biological Process GO:0045725 positive regulation of glycogen biosynthetic process
Biological Process GO:0046628 positive regulation of insulin receptor signaling pathway
Biological Process GO:0046889 positive regulation of lipid biosynthetic process
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0043149 stress fiber assembly
molecular function GO:0003779 actin binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0005158 insulin receptor binding
molecular function GO:0030159 signaling receptor complex adaptor activity
cellular component GO:0005912 adherens junction
cellular component GO:0030055 cell-substrate junction
cellular component GO:0005813 centrosome
cellular component GO:0005829 cytosol
cellular component GO:0005925 focal adhesion
cellular component GO:0045121 membrane raft
cellular component GO:0016363 nuclear matrix
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0001725 stress fiber
cellular component GO:0005915 zonula adherens
Reactome
Pathway Id Pathway Name
R-HSA-397014 Muscle contraction
R-HSA-445355 Smooth Muscle Contraction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0003175 BXGD000187 Anthrax disease Infections
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007125 BXGD000438 Carcinoma, Ehrlich Tumor Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014009 BXGD000876 Empyema Pathological Conditions, Signs and Symptoms; Infections
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018621 BXGD001210 Hay fever Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032300 BXGD002346 Lobar Pneumonia Infections; Respiratory Tract Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041912 BXGD002937 Upper Respiratory Infections Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0155862 BXGD003827 Streptococcal pneumonia Infections; Respiratory Tract Diseases
C0205969 BXGD004143 Thymic Carcinoma Neoplasms; Hemic and Lymphatic Diseases
C0206081 BXGD004152 Hyperandrogenism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0206526 BXGD004180 Tuberculosis, Multidrug-Resistant Infections
C0237123 BXGD004845 Alcohol or Other Drugs use
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0266815 BXGD005717 Cow milk allergy Digestive System Diseases; Immune System Diseases
C0271994 BXGD006290 Hereditary persistence of fetal hemoglobin thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0275524 BXGD006376 Coinfection Infections
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0312414 BXGD006886 Menstrual spotting
C0333559 BXGD006960 Infarction, Lacunar Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0333875 BXGD006972 High-Grade Squamous Intraepithelial Lesions Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0339901 BXGD007289 Acute respiratory infections Infections; Respiratory Tract Diseases
C0342541 BXGD007499 Precocious pubarche Endocrine System Diseases
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0472767 BXGD008918 Beta thalassemia intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0476227 BXGD008981 pricking of skin
C0581381 BXGD009567 Recurrent upper respiratory tract infection Infections; Respiratory Tract Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0694549 BXGD009851 Community acquired pneumonia Infections; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740919 BXGD010016 Allergy to grass pollen Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C0751955 BXGD010652 Brain Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0871470 BXGD011316 Systolic Pressure
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0917799 BXGD011410 Hypersomnia Nervous System Diseases; Mental Disorders
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0949570 BXGD011579 Wheat Hypersensitivity Immune System Diseases
C1142536 BXGD011759 Pneumonia due to methicillin resistant Staphylococcus aureus Infections; Respiratory Tract Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1320214 BXGD012421 Invasive Streptococcus pneumoniae disease Infections
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1443237 BXGD013069 Healthcare associated pneumonia Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512127 BXGD013185 HER2 gene amplification
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1827301 BXGD013769 Extensively Drug-Resistant Tuberculosis Infections
C1868594 BXGD016511 Perry Syndrome Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3280586 BXGD018846 Mannose-Binding Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3662483 BXGD019270 Allergic sensitization
C3669246 BXGD019326 Mammary adenocarcinoma
C3841475 BXGD019800 beta^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4024896 BXGD021461 Motor neuron atrophy
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4723838 BXGD023809 Metastatic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0006368 Formic acid 46.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein