protein

Showing entry for Tyrosine-protein kinase ZAP-70

General Target Information
BXGT Id	BXGT010385
Protein Name	Tyrosine-protein kinase ZAP-70
Uniport Id	P43403
Gene	ZAP70
Gene Id	7535
Domain	Pkinase_Tyr; SH2
Pfam	PF07714 PF00017
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
3. Environmental Information Processing	3.2 Signal transduction	hsa04014	Ras signaling pathway
3. Environmental Information Processing	3.2 Signal transduction	hsa04064	NF-kappa B signaling pathway
5. Organismal Systems	5.1 Immune system	hsa04650	Natural killer cell mediated cytotoxicity
5. Organismal Systems	5.1 Immune system	hsa04658	Th1 and Th2 cell differentiation
5. Organismal Systems	5.1 Immune system	hsa04659	Th17 cell differentiation
5. Organismal Systems	5.1 Immune system	hsa04660	T cell receptor signaling pathway
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05135	Yersinia infection
6. Human Diseases	6.1 Cancers: Overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer
6. Human Diseases	6.3 Immune diseases	hsa05340	Primary immunodeficiency

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0042113	B cell activation
Biological Process	GO:0043366	beta selection
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0006955	immune response
Biological Process	GO:0045087	innate immune response
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0045060	negative thymic T cell selection
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation
Biological Process	GO:0046638	positive regulation of alpha-beta T cell differentiation
Biological Process	GO:0046641	positive regulation of alpha-beta T cell proliferation
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling
Biological Process	GO:0045582	positive regulation of T cell differentiation
Biological Process	GO:0045059	positive thymic T cell selection
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0042127	regulation of cell population proliferation
Biological Process	GO:0042110	T cell activation
Biological Process	GO:0070489	T cell aggregation
Biological Process	GO:0030217	T cell differentiation
Biological Process	GO:0072678	T cell migration
Biological Process	GO:0050852	T cell receptor signaling pathway
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
molecular function	GO:0005524	ATP binding
molecular function	GO:0004715	non-membrane spanning protein tyrosine kinase activity
molecular function	GO:0001784	phosphotyrosine residue binding
molecular function	GO:0004713	protein tyrosine kinase activity
molecular function	GO:0005102	signaling receptor binding
cellular component	GO:0005911	cell-cell junction
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
cellular component	GO:0001772	immunological synapse
cellular component	GO:0005886	plasma membrane
cellular component	GO:0042101	T cell receptor complex

Reactome

Pathway Id	Pathway Name
R-HSA-1280218	Adaptive Immune System
R-HSA-168256	Immune System
R-HSA-202403	TCR signaling
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse
R-HSA-202433	Generation of second messenger molecules

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002880	BXGD000139	Autoimmune hemolytic anemia	Immune System Diseases; Hemic and Lymphatic Diseases
C0003257	BXGD000189	Antibody Deficiency Syndrome	Immune System Diseases
C0003811	BXGD000222	Cardiac Arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114	BXGD000255	Astrocytoma	Neoplasms
C0004238	BXGD000262	Atrial Fibrillation	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004368	BXGD000271	Autoimmune state
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006413	BXGD000397	Burkitt Lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0008626	BXGD000559	Congenital chromosomal disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009663	BXGD000618	Condylomata Acuminata	Infections; Skin and Connective Tissue Diseases
C0009812	BXGD000634	Constitutional Symptom
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0011615	BXGD000738	Dermatitis, Atopic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0012236	BXGD000772	DiGeorge Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0013595	BXGD000858	Eczema	Skin and Connective Tissue Diseases
C0014060	BXGD000882	Encephalitis, St. Louis	Infections; Nervous System Diseases
C0014457	BXGD000915	Eosinophilia	Hemic and Lymphatic Diseases
C0015230	BXGD000969	Exanthema	Skin and Connective Tissue Diseases
C0015544	BXGD001003	Failure to Thrive	Pathological Conditions, Signs and Symptoms
C0017638	BXGD001132	Glioma	Neoplasms
C0018081	BXGD001171	Gonorrhea	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0018939	BXGD001253	Hematological Disease	Hemic and Lymphatic Diseases
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0019209	BXGD001305	Hepatomegaly	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019214	BXGD001307	Hepatosplenomegaly	Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0019348	BXGD001325	Herpes Simplex Infections	Infections; Skin and Connective Tissue Diseases
C0019829	BXGD001350	Hodgkin Disease	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020981	BXGD001474	Angioimmunoblastic Lymphadenopathy	Immune System Diseases; Hemic and Lymphatic Diseases
C0021051	BXGD001475	Immunologic Deficiency Syndromes	Immune System Diseases
C0023055	BXGD001604	Laryngeal neoplasm	Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023418	BXGD001642	leukemia	Neoplasms
C0023434	BXGD001643	Chronic Lymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023448	BXGD001649	Lymphoid leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449	BXGD001650	Acute lymphocytic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023473	BXGD001661	Myeloid Leukemia, Chronic	Neoplasms; Hemic and Lymphatic Diseases
C0023485	BXGD001667	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023493	BXGD001672	Adult T-Cell Lymphoma/Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024205	BXGD001744	Lymphadenitis	Hemic and Lymphatic Diseases
C0024282	BXGD001755	Lymphocytosis	Hemic and Lymphatic Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301	BXGD001759	Lymphoma, Follicular	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305	BXGD001763	Lymphoma, Non-Hodgkin	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312	BXGD001766	Lymphopenia	Immune System Diseases; Hemic and Lymphatic Diseases
C0024314	BXGD001767	Lymphoproliferative Disorders	Immune System Diseases; Hemic and Lymphatic Diseases
C0024419	BXGD001769	Waldenstrom Macroglobulinemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026764	BXGD001928	Multiple Myeloma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026847	BXGD001940	Spinal Muscular Atrophy	Nervous System Diseases
C0026936	BXGD001950	Mycoplasma Infections	Infections
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028945	BXGD002099	oligodendroglioma	Neoplasms
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030354	BXGD002214	Papilloma	Neoplasms
C0030489	BXGD002230	Paraproteinemias	Immune System Diseases; Hemic and Lymphatic Diseases
C0030805	BXGD002256	Bullous pemphigoid	Skin and Connective Tissue Diseases; Immune System Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0033581	BXGD002410	prostatitis	Male Urogenital Diseases
C0033687	BXGD002415	Proteinuria	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035243	BXGD002522	Respiratory Tract Infections	Infections; Respiratory Tract Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0036916	BXGD002643	Sexually Transmitted Diseases	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0037274	BXGD002676	Dermatologic disorders	Skin and Connective Tissue Diseases
C0038002	BXGD002723	Splenomegaly	Pathological Conditions, Signs and Symptoms
C0038015	BXGD002726	Spondyloepiphyseal Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0038362	BXGD002749	Stomatitis	Stomatognathic Diseases
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0039128	BXGD002794	Syphilis	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0041976	BXGD002946	Urethritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042769	BXGD002999	Virus Diseases	Infections
C0079731	BXGD003087	B-Cell Lymphomas	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744	BXGD003090	Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772	BXGD003099	T-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079774	BXGD003101	Peripheral T-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110	BXGD003126	Severe Combined Immunodeficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085166	BXGD003136	Bacterial Vaginosis	Female Urogenital Diseases and Pregnancy Complications; Infections
C0085183	BXGD003139	Neoplasms, Second Primary	Neoplasms
C0086543	BXGD003294	Cataract	Eye Diseases
C0149678	BXGD003346	Epstein-Barr Virus Infections	Infections
C0149985	BXGD003399	Syphilis, secondary	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0151281	BXGD003409	Genital ulcers
C0206180	BXGD004170	Ki-1+ Anaplastic Large Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220597	BXGD004292	Adult Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644	BXGD004306	Childhood Hodgkin Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0242510	BXGD005173	Drug usage	Chemically-Induced Disorders; Mental Disorders
C0242583	BXGD005178	Bare Lymphocyte Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0242596	BXGD005181	Neoplasm, Residual	Pathological Conditions, Signs and Symptoms; Neoplasms
C0242647	BXGD005184	Mucosa-Associated Lymphoid Tissue Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0264700	BXGD005415	Acute Inferior Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0265253	BXGD005484	Stickler syndrome (disorder)	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases
C0265279	BXGD005496	Kniest dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Respiratory Tract Diseases; Endocrine System Diseases; Stomatognathic Diseases
C0271093	BXGD006162	Stargardt's disease
C0275524	BXGD006376	Coinfection	Infections
C0278764	BXGD006581	Adult Burkitt Lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879	BXGD006610	Childhood Burkitt Lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279070	BXGD006625	Adult Oligodendroglioma	Neoplasms
C0279626	BXGD006657	Squamous cell carcinoma of esophagus	Digestive System Diseases; Neoplasms
C0280475	BXGD006749	Childhood Oligodendroglioma	Neoplasms
C0333875	BXGD006972	High-Grade Squamous Intraepithelial Lesions	Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334633	BXGD007143	Malignant lymphoma - lymphoplasmacytic	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0343641	BXGD007636	Human papilloma virus infection	Infections
C0344530	BXGD007688	Congenital keratoglobus	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0349631	BXGD007938	Richter's syndrome	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0349636	BXGD007941	Pre B-cell acute lymphoblastic leukemia
C0398650	BXGD008212	Immune thrombocytopenic purpura	Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0401151	BXGD008274	Chronic diarrhea	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0409652	BXGD008390	Seronegative rheumatoid arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432408	BXGD008785	Trisomy 12	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0456889	BXGD008881	Enteropathy-Associated T-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0475801	BXGD008971	Leukemia, Prolymphocytic, B-Cell	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0494261	BXGD009023	Combined immunodeficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0497156	BXGD009053	Lymphadenopathy	Hemic and Lymphatic Diseases
C0518948	BXGD009072	Chlamydia trachomatis infection	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0521707	BXGD009166	Bilateral cataracts (disorder)	Eye Diseases
C0524909	BXGD009247	Hepatitis B, Chronic	Digestive System Diseases; Infections
C0553580	BXGD009399	Ewings sarcoma	Neoplasms
C0574785	BXGD009506	Lower Urinary Tract Symptoms	Pathological Conditions, Signs and Symptoms
C0596887	BXGD009648	mathematical ability
C0677932	BXGD009736	Progressive Neoplastic Disease
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684275	BXGD009792	Hemophilia, NOS	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0700216	BXGD009881	Structural Clinical Interview for DSM-III
C0700345	BXGD009886	Candidiasis, Vulvovaginal	Female Urogenital Diseases and Pregnancy Complications; Infections
C0729353	BXGD009924	Subfertility	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751396	BXGD010425	Well Differentiated Oligodendroglioma	Neoplasms
C0751606	BXGD010523	Adult Acute Lymphocytic Leukemia
C0795845	BXGD010749	Chromosome 12, 12p trisomy	Pathological Conditions, Signs and Symptoms
C0855139	BXGD011076	Monocytoid B-cell lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0855146	BXGD011077	B Lymphoblastic Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0949690	BXGD011584	Spondylarthritis	Musculoskeletal Diseases
C1112709	BXGD011682	non-gonococcal urethritis (NGU)	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C1261473	BXGD011855	Sarcoma	Neoplasms
C1263762	BXGD011896	Endocervical adenocarcinoma
C1269955	BXGD012005	Tumor Cell Invasion
C1274233	BXGD012028	T-lymphocyte immunodeficiency	Immune System Diseases
C1292769	BXGD012230	Precursor B-cell lymphoblastic leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1299237	BXGD012253	Endocervical Carcinoma
C1301362	BXGD012291	Primary Cutaneous Anaplastic Large Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1302424	BXGD012304	Plasma cell myeloma/plasmacytoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C1302547	BXGD012305	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1302773	BXGD012312	Low Grade Squamous Intraepithelial Neoplasia	Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306759	BXGD012374	Eosinophilic disorder	Hemic and Lymphatic Diseases
C1321551	BXGD012436	Shprintzen-Goldberg syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C1328587	BXGD012473	Panhypogammaglobulinemia
C1332201	BXGD012502	Adult Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1334170	BXGD012683	Indolent Non-Hodgkin Lymphoma
C1334274	BXGD012695	Invasive Carcinoma	Neoplasms
C1519680	BXGD013244	Tumor Immunity	Pathological Conditions, Signs and Symptoms
C1536220	BXGD013341	ST segment elevation myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1744558	BXGD013748	T-lymphocyte deficiency
C1832324	BXGD013828	Recurrent opportunistic infections	Infections
C1835686	BXGD014043	Recurrent bacterial skin infections
C1837066	BXGD014190	Recurrent viral infection	Infections
C1842777	BXGD014537	Recurrent upper and lower respiratory tract infections
C1849236	BXGD015026	Severe combined immunodeficiency, atypical	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1854495	BXGD015410	Recurrent infection of the gastrointestinal tract
C1860128	BXGD015957	Recurrent candida infections
C1868683	BXGD016526	B-CELL MALIGNANCY, LOW-GRADE
C1883018	BXGD016594	Severe Aplastic Anemia	Hemic and Lymphatic Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C1961102	BXGD016673	Precursor Cell Lymphoblastic Leukemia Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2004493	BXGD016875	Leukemia, B-Cell	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2020284	BXGD016881	Stickler syndrome, type 1	Pathological Conditions, Signs and Symptoms; Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2363741	BXGD017100	HIV-1 infection
C2700553	BXGD017472	Omenn Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C2745959	BXGD017570	Spondyloepiphyseal dysplasia, congenita	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2931299	BXGD018000	ZAP70 deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C2931320	BXGD018002	T cell immunodeficiency primary	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3160909	BXGD018497	Autoimmune arthritis
C3539781	BXGD019086	Progressive cGVHD
C3553449	BXGD019174	PONTOCEREBELLAR HYPOPLASIA, TYPE 1B
C3854222	BXGD019826	Human immunodeficiency virus (HIV) II infection category B1
C3854434	BXGD019834	Bone marrow infiltration	Hemic and Lymphatic Diseases
C3896960	BXGD020042	Childhood Pre-B Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C3896961	BXGD020043	Adult Pre-B Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4023438	BXGD021185	Recurrent mycobacterial infections
C4024599	BXGD021333	Chronic oral candidiasis	Infections; Skin and Connective Tissue Diseases
C4025197	BXGD021587	Absence of CD8-positive T cells
C4086152	BXGD022123	Childhood Astrocytoma	Neoplasms
C4255010	BXGD022310	Non-ST Elevated Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4275079	BXGD022364	Posterior cortical atrophy syndrome
C4290046	BXGD022507	trachomatis
C4310768	BXGD022658	AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
C4524092	BXGD023092	Chronic rhinosinusitis with nasal polyps
C4531166	BXGD023200	Decreased lymphocyte proliferation in response to mitogen
C4551686	BXGD023391	Malignant neoplasm of soft tissue	Neoplasms
C4552766	BXGD023523	Miscarriage	Female Urogenital Diseases and Pregnancy Complications
C4721414	BXGD023738	Mantle cell lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721452	BXGD023743	Intestinal T-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum
C4749304	BXGD024055	Monosomy 13q14 syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002588	Magnesium		24.31
BXGC0002702	Lead		207.2
BXGC0012352	Chelerythrine		348.12
BXGC0016254	Dehydroabietic Acid		300.21
BXGC0044857	Sp-600125		220.06
BXGC0045254	Sb-202190		331.11
BXGC0047692	Gefitinib		446.15
BXGC0050099	(2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione		362.14

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}