Showing entry for Leucyl-cystinyl aminopeptidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021721
Protein NameLeucyl-cystinyl aminopeptidase
Uniport IdQ9UIQ6
GeneLNPEP
Gene Id4012
DomainERAP1_C; Peptidase_M1; Peptidase_M1_N
Pfam PF11838   PF01433  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04614 Renin-angiotensin system
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007565 female pregnancy
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0043171 peptide catabolic process
Biological Process GO:0030163 protein catabolic process
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0060395 SMAD protein signal transduction
molecular function GO:0004177 aminopeptidase activity
molecular function GO:0070006 metalloaminopeptidase activity
molecular function GO:0008237 metallopeptidase activity
molecular function GO:0042277 peptide binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0005829 cytosol
cellular component GO:0031905 early endosome lumen
cellular component GO:0005576 extracellular region
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005765 lysosomal membrane
cellular component GO:0016020 membrane
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-1280218 Adaptive Immune System
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0003175 BXGD000187 Anthrax disease Infections
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004623 BXGD000282 Bacterial Infections Infections
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007125 BXGD000438 Carcinoma, Ehrlich Tumor Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009319 BXGD000596 Colitis Digestive System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0010633 BXGD000679 Cystadenoma Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011848 BXGD000750 Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014009 BXGD000876 Empyema Pathological Conditions, Signs and Symptoms; Infections
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018621 BXGD001210 Hay fever Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022665 BXGD001573 Kidney Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025261 BXGD001843 Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032227 BXGD002336 Pleural effusion disorder Respiratory Tract Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032300 BXGD002346 Lobar Pneumonia Infections; Respiratory Tract Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036631 BXGD002626 Seminoma Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039538 BXGD002819 Teratoma Neoplasms
C0039730 BXGD002826 Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041912 BXGD002937 Upper Respiratory Infections Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0087031 BXGD003319 Juvenile-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0152244 BXGD003571 Bone Cysts, Aneurysmal Neoplasms; Musculoskeletal Diseases
C0155862 BXGD003827 Streptococcal pneumonia Infections; Respiratory Tract Diseases
C0162283 BXGD003927 Nephrogenic Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0162739 BXGD003979 HELLP Syndrome Female Urogenital Diseases and Pregnancy Complications
C0200635 BXGD004041 Lymphocyte Count measurement
C0205969 BXGD004143 Thymic Carcinoma Neoplasms; Hemic and Lymphatic Diseases
C0206526 BXGD004180 Tuberculosis, Multidrug-Resistant Infections
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0237123 BXGD004845 Alcohol or Other Drugs use
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266815 BXGD005717 Cow milk allergy Digestive System Diseases; Immune System Diseases
C0271994 BXGD006290 Hereditary persistence of fetal hemoglobin thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0275524 BXGD006376 Coinfection Infections
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0312414 BXGD006886 Menstrual spotting
C0333875 BXGD006972 High-Grade Squamous Intraepithelial Lesions Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0339901 BXGD007289 Acute respiratory infections Infections; Respiratory Tract Diseases
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0472767 BXGD008918 Beta thalassemia intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0476227 BXGD008981 pricking of skin
C0581381 BXGD009567 Recurrent upper respiratory tract infection Infections; Respiratory Tract Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678213 BXGD009748 Complete hydatidiform mole Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0694549 BXGD009851 Community acquired pneumonia Infections; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740919 BXGD010016 Allergy to grass pollen Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C0751292 BXGD010380 Age-Related Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751293 BXGD010381 Memory Disorder, Semantic Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751294 BXGD010382 Memory Disorder, Spatial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751295 BXGD010383 Memory Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0917799 BXGD011410 Hypersomnia Nervous System Diseases; Mental Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0949570 BXGD011579 Wheat Hypersensitivity Immune System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1142536 BXGD011759 Pneumonia due to methicillin resistant Staphylococcus aureus Infections; Respiratory Tract Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1320214 BXGD012421 Invasive Streptococcus pneumoniae disease Infections
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1368898 BXGD012904 Adult Teratoma Neoplasms
C1384600 BXGD012945 Systemic onset juvenile chronic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C1411966 BXGD013047 Clostridium; difficile (disorder)
C1443237 BXGD013069 Healthcare associated pneumonia Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C1455728 BXGD013105 Acute fatty liver of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1512127 BXGD013185 HER2 gene amplification
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1827301 BXGD013769 Extensively Drug-Resistant Tuberculosis Infections
C1853959 BXGD015372 Birdshot chorioretinopathy
C1858558 BXGD015806 Rheumatoid Arthritis, Systemic Juvenile Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C1868594 BXGD016511 Perry Syndrome Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347762 BXGD017050 Childhood Teratoma Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931171 BXGD017967 Juvenile pauciarticular chronic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C2932666 BXGD018096 Gestational Diabetes Insipidus Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3280586 BXGD018846 Mannose-Binding Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3662483 BXGD019270 Allergic sensitization
C3669246 BXGD019326 Mammary adenocarcinoma
C3841475 BXGD019800 beta^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3890205 BXGD020020 Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3898105 BXGD020059 Oligoarticular Juvenile Idiopathic Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4024896 BXGD021461 Motor neuron atrophy
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4723838 BXGD023809 Metastatic Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001380 Succinic acid 118.09
BXGC0014116 Lysine 147.11
BXGC0018397 beta-1,4-mannan 180.06
BXGC0030612 tetraethylene glycol 194.12
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein