Showing entry for Hepatocyte growth factor-regulated tyrosine kinase substrate


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004116
Protein NameHepatocyte growth factor-regulated tyrosine kinase substrate
Uniport IdO14964
GeneHGS
Gene Id9146
DomainFYVE; Hrs_helical; VHS
Pfam PF01363   PF12210   PF00790  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0016197 endosomal transport
Biological Process GO:0016236 macroautophagy
Biological Process GO:0010324 membrane invagination
Biological Process GO:0061024 membrane organization
Biological Process GO:0036258 multivesicular body assembly
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
Biological Process GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0072657 protein localization to membrane
Biological Process GO:0006622 protein targeting to lysosome
Biological Process GO:0043405 regulation of MAP kinase activity
Biological Process GO:0042176 regulation of protein catabolic process
Biological Process GO:0007165 signal transduction
molecular function GO:0046872 metal ion binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0044389 ubiquitin-like protein ligase binding
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0005768 endosome
cellular component GO:0033565 ESCRT-0 complex
cellular component GO:0070062 extracellular exosome
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005764 lysosome
cellular component GO:0032585 multivesicular body membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-177929 Signaling by EGFR
R-HSA-182971 EGFR downregulation
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-392499 Metabolism of proteins
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-6806834 Signaling by MET
R-HSA-6807004 Negative regulation of MET activity
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8876384 Listeria monocytogenes entry into host cells
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-9635644 Inhibition of membrane repair
R-HSA-9636383 Prevention of phagosomal-lysosomal fusion
R-HSA-9637687 Suppression of phagosomal maturation
R-HSA-9637690 Response of Mtb to phagocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003431 BXGD000190 Antisocial Personality Disorder Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019212 BXGD001306 Hepatorenal Syndrome Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022672 BXGD001574 Acute Kidney Tubular Necrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0036346 BXGD002602 Schizophrenia, Childhood Mental Disorders
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221043 BXGD004377 Liddle Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242966 BXGD005201 Systemic Inflammatory Response Syndrome Pathological Conditions, Signs and Symptoms
C0270549 BXGD006079 Generalized Anxiety Disorder Mental Disorders
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0347016 BXGD007846 Secondary malignant neoplasm of spinal cord Neoplasms; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0730285 BXGD009943 Diabetic macular edema Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0872084 BXGD011319 Sarcopenia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1141890 BXGD011721 Congenital long QT syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1333064 BXGD012587 Classical Hodgkin's Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347747 BXGD017040 Adult Classical Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein