Showing entry for Group 10 secretory phospholipase A2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004175
Protein NameGroup 10 secretory phospholipase A2
Uniport IdO15496
GenePLA2G10
Gene Id8399
DomainPhospholip_A2_1
Pfam PF00068  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00564 Glycerophospholipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00565 Ether lipid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00591 Linoleic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00592 alpha-Linolenic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04975 Fat digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019369 arachidonic acid metabolic process
Biological Process GO:0050482 arachidonic acid secretion
Biological Process GO:0007411 axon guidance
Biological Process GO:1990830 cellular response to leukemia inhibitory factor
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0051607 defense response to virus
Biological Process GO:0043249 erythrocyte maturation
Biological Process GO:0009566 fertilization
Biological Process GO:0031069 hair follicle morphogenesis
Biological Process GO:0036335 intestinal stem cell homeostasis
Biological Process GO:0034374 low-density lipoprotein particle remodeling
Biological Process GO:0051977 lysophospholipid transport
Biological Process GO:0042116 macrophage activation
Biological Process GO:0090370 negative regulation of cholesterol efflux
Biological Process GO:1900016 negative regulation of cytokine production involved in inflammatory response
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0006654 phosphatidic acid biosynthetic process
Biological Process GO:0046473 phosphatidic acid metabolic process
Biological Process GO:0036151 phosphatidylcholine acyl-chain remodeling
Biological Process GO:0034638 phosphatidylcholine catabolic process
Biological Process GO:0046470 phosphatidylcholine metabolic process
Biological Process GO:0036152 phosphatidylethanolamine acyl-chain remodeling
Biological Process GO:0046337 phosphatidylethanolamine metabolic process
Biological Process GO:0036148 phosphatidylglycerol acyl-chain remodeling
Biological Process GO:0046471 phosphatidylglycerol metabolic process
Biological Process GO:0036149 phosphatidylinositol acyl-chain remodeling
Biological Process GO:0036150 phosphatidylserine acyl-chain remodeling
Biological Process GO:0006658 phosphatidylserine metabolic process
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0062234 platelet activating factor catabolic process
Biological Process GO:2000344 positive regulation of acrosome reaction
Biological Process GO:0090238 positive regulation of arachidonic acid secretion
Biological Process GO:0032270 positive regulation of cellular protein metabolic process
Biological Process GO:0010884 positive regulation of lipid storage
Biological Process GO:0010744 positive regulation of macrophage derived foam cell differentiation
Biological Process GO:0032308 positive regulation of prostaglandin secretion
Biological Process GO:0002532 production of molecular mediator involved in inflammatory response
Biological Process GO:0001516 prostaglandin biosynthetic process
Biological Process GO:0043030 regulation of macrophage activation
molecular function GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
molecular function GO:0047498 calcium-dependent phospholipase A2 activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0004623 phospholipase A2 activity
molecular function GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
molecular function GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
molecular function GO:0004620 phospholipase activity
molecular function GO:0005543 phospholipid binding
cellular component GO:0001669 acrosomal vesicle
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005764 lysosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1483166 Synthesis of PA
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001486 BXGD000056 Adenovirus Infections Infections
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0032231 BXGD002339 Pleurisy Infections; Respiratory Tract Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035220 BXGD002512 Respiratory Distress Syndrome, Newborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0039292 BXGD002807 Tangier Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0270500 BXGD006077 Coprophilia (disorder) Mental Disorders
C0334037 BXGD006980 Intestinal metaplasia
C0338106 BXGD007167 Adenocarcinoma of colon Digestive System Diseases; Neoplasms
C0349218 BXGD007895 Recurrent depressive disorder Mental Disorders
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684256 BXGD009791 Bacterial sepsis Pathological Conditions, Signs and Symptoms; Infections
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C1257915 BXGD011813 Intestinal Polyposis Digestive System Diseases
C1260881 BXGD011838 Allergic bronchitis Infections; Respiratory Tract Diseases; Immune System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1654637 BXGD013484 androgen independent prostate cancer
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2350019 BXGD017066 Solitary Pulmonary Nodule Respiratory Tract Diseases
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0002064 Amentoflavone 538.46
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0014122 Ochnaflavone 538.09
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein