Showing entry for Amentoflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0002064
Compound NameAmentoflavone
Structure
FormulaC30H18O10
InchiKeyYUSWMAULDXZHPY-UHFFFAOYSA-N
SMILESOC1=CC=C(C=C1)C1=CC(=O)C2=C(O)C=C(O)C(=C2O1)C1=C(O)C=CC(=C1)C1=CC(=O)C2=C(O)C=C(O)C=C2O1
InchiInChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
IUPAC8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Molecular Weight538.46
Pubchem Id5281600
Chembl IdCHEMBL63354
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL63354
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9ES14 BXGT020314 Gamma-aminobutyric acid receptor subunit epsilon reviewed - Gabre IC50 '=' 14 nM
Q91ZM7 BXGT019327 GABA theta subunit unreviewed - Gabrq IC50 '=' 14 nM
P63138 BXGT011502 Gamma-aminobutyric acid receptor subunit beta-2 reviewed - Gabrb2 IC50 '=' 14 nM
P63079 BXGT011491 Gamma-aminobutyric acid receptor subunit beta-3 reviewed - Gabrb3 IC50 '=' 14 nM
P62813 BXGT011460 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed - Gabra1 IC50 '=' 14 nM
P30191 BXGT009410 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed - Gabra6 IC50 '=' 14 nM
P28473 BXGT009261 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed - Gabrg3 IC50 '=' 14 nM
P28471 BXGT009259 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed - Gabra4 IC50 '=' 14 nM
P23576 BXGT008885 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed - Gabra2 IC50 '=' 14 nM
P23574 BXGT008884 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed - Gabrg1 IC50 '=' 14 nM
P20236 BXGT008551 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed - Gabra3 IC50 '=' 14 nM
P19969 BXGT008536 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed - Gabra5 IC50 '=' 14 nM
P18508 BXGT008412 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed - Gabrg2 IC50 '=' 14 nM
P18506 BXGT008410 Gamma-aminobutyric acid receptor subunit delta reviewed - Gabrd IC50 '=' 14 nM
P15431 BXGT008122 Gamma-aminobutyric acid receptor subunit beta-1 reviewed - Gabrb1 IC50 '=' 14 nM
O09028 BXGT004049 Gamma-aminobutyric acid receptor subunit pi reviewed - Gabrp IC50 '=' 14 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 17782 nM
Q16445 BXGT013629 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed Ion channel GABRA6 Ki '=' 6 nM
P31644 BXGT009557 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed Ion channel GABRA5 Ki '=' 6 nM
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed Ion channel GABRA2 Ki '=' 6 nM
P78334 BXGT011834 Gamma-aminobutyric acid receptor subunit epsilon reviewed Ion channel GABRE Ki '=' 6 nM
P18505 BXGT008409 Gamma-aminobutyric acid receptor subunit beta-1 reviewed Ion channel GABRB1 Ki '=' 6 nM
Q8N1C3 BXGT018498 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed Ion channel GABRG1 Ki '=' 6 nM
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta reviewed Ion channel GABRD Ki '=' 6 nM
O00591 BXGT003939 Gamma-aminobutyric acid receptor subunit pi reviewed Ion channel GABRP Ki '=' 6 nM
P34903 BXGT009769 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed Ion channel GABRA3 Ki '=' 6 nM
Q9UN88 BXGT021783 Gamma-aminobutyric acid receptor subunit theta reviewed Ion channel GABRQ Ki '=' 6 nM
Q99928 BXGT019975 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed Ion channel GABRG3 Ki '=' 6 nM
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed Ion channel GABRA4 Ki '=' 6 nM
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 reviewed Ion channel GABRB3 Ki '=' 6 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 Ki '=' 6 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 Ki '=' 6 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 Ki '=' 6 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 2555 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 '=' 1540 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ke '=' 6000 nM
P15692 BXGT008147 Vascular endothelial growth factor A reviewed Signaling VEGFA Kd '=' 16 nM
Q8IEK1 BXGT018263 M1-family alanyl aminopeptidase unreviewed - PF3D7_1311800 IC50 '=' 108390 nM
P0C6X7 BXGT007440 Replicase polyprotein 1ab reviewed - rep IC50 '=' 8300 nM
P08487 BXGT006778 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 reviewed - PLCG1 IC50 '=' 29000 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki '=' 36 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 79432 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Intrinsic activity - - -
P79400 BXGT011863 5-hydroxytryptamine receptor 1D reviewed - HTR1D Ki '=' 4094 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 100 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7079 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 19952 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 19952 nM
P10520 BXGT007576 Streptokinase A reviewed - ska EC50 '=' 2298 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki '=' 36 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 IC50 '=' 281838293 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 IC50 '=' 281838293 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 IC50 '=' 281838293 nM
P65502 BXGT011541 Probable nicotinate-nucleotide adenylyltransferase reviewed - nadD IC50 - 29400 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Intrinsic activity - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ke '>' 10000 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 25118 nM
P04055 BXGT006137 Phospholipase A2 reviewed - Pla2g1b IC50 '>' 100000 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 56234 nM
P79291 BXGT011860 Delta-type opioid receptor reviewed - OPRD1 Ki '=' 36 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '=' 1241 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse Inhibition '=' 97 %
P19174 BXGT008467 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 reviewed Enzyme PLCG1 IC50 '=' 29000 nM
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase reviewed - VCP IC50 '=' 8984 nM
Q9WKE8 BXGT021921 Reverse transcriptase unreviewed - reverse IC50 '=' 119000 nM
P14555 BXGT008020 Phospholipase A2, membrane associated reviewed Enzyme PLA2G2A IC50 '=' 23800 nM
P10520 BXGT007576 Streptokinase A reviewed - ska EC50 '>' 150000 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 EC50 '=' 3600 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 EC50 '=' 3600 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 EC50 '=' 3600 nM
P43235 BXGT010368 Cathepsin K reviewed Enzyme CTSK IC50 '=' 1 ug.mL-1
P17405 BXGT008304 Sphingomyelin phosphodiesterase reviewed Enzyme SMPD1 Potency - 89125 nM
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 Activity - - -
P0C6X7 BXGT007440 Replicase polyprotein 1ab reviewed - rep Ki '=' 13800 nM
P65502 BXGT011541 Probable nicotinate-nucleotide adenylyltransferase reviewed - nadD IC50 - 9380 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 44668 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 39810 nM
P47712 BXGT010577 Cytosolic phospholipase A2 reviewed Enzyme PLA2G4A IC50 '>' 100000 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 10000 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 14125 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 44668 nM
O15496 BXGT004175 Group 10 secretory phospholipase A2 reviewed Enzyme PLA2G10 IC50 '>' 100000 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 1634 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 5173 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 5173 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 5173 nM
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase reviewed - VCP IC50 '>' 50000 nM
P49763 BXGT010737 Placenta growth factor reviewed Signaling PGF Kd '=' 8 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 22387 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 19952 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 50118 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Kd '=' 2180 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 47754 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 35300 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 4466 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition - - -
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 IC50 '=' 30310 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 50118 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Ki '=' 7800 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 125892 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 31622 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 IC50 '=' 7400 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 33807 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 70794 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Intrinsic activity - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ke '=' 490 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 31622 nM
Q60795 BXGT016000 Nuclear factor erythroid 2-related factor 2 reviewed - Nfe2l2 FC '=' 1 -
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 21192 nM
P35821 BXGT009871 Tyrosine-protein phosphatase non-receptor type 1 reviewed - Ptpn1 Inhibition - - -
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 IC50 '>' 100000 nM
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 39810 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 '=' 1270 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 '=' 2580 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00002 Savoy cabbage Brassica oleracea var. sabauda Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00823 Fruits Fruits
BXGF00966 Tristania conferta Tristania conferta Others
BXGF00972 Plectranthus myrianthus Plectranthus myrianthus Others
BXGF01024 Pentaclethra macrophylla Pentaclethra macrophylla Medicinal Plant
BXGF01085 Veronica polita Veronica polita Medicinal Plant
BXGF01108 Eurybia divaricata Eurybia divaricata Garden Plant
BXGF01183 Glycosmis macrophylla Glycosmis macrophylla Others
BXGF01253 Stephania zippeliana Stephania zippeliana Others
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF01329 Eucalyptus apodophylla Eucalyptus apodophylla Medicinal Plant
BXGF01416 Hypericum polyanthemum Hypericum polyanthemum Others
BXGF01418 Distephanus angulifolius Distephanus angulifolius Others
BXGF01467 Torreya fargesii var. yunnanensis Torreya fargesii var. yunnanensis Medicinal Plant
BXGF01480 Periploca sepium Periploca sepium Medicinal Plant
BXGF01495 Pleione yunnanensis Pleione yunnanensis Others
BXGF01548 Campylotropis hirtella Campylotropis hirtella Medicinal Plant
BXGF01728 Selaginella uncinata Selaginella uncinata Medicinal Plant
BXGF01780 Selaginella tamariscina Selaginella tamariscina Medicinal Plant
BXGF02009 Phyllosma capensis Phyllosma capensis Others
BXGF02035 Proustia ilicifolia Proustia ilicifolia Others
BXGF02204 Apocynum venetum Apocynum venetum Medicinal Plant
BXGF02268 Ginkgo semen Ginkgo semen Others
BXGF02463 Selaginella doederleinii hieron Selaginella doederleinii hieron Others
BXGF02479 Torreya nuncifera Torreya nuncifera Others
BXGF02496 Pleione bulbocodioides Pleione bulbocodioides Others
BXGF02499 Cremastra appendiculata Cremastra appendiculata Medicinal Plant
BXGF02574 Torreya grandis Torreya grandis Medicinal Plant
BXGF02633 Breonia chinensis Breonia chinensis Medicinal Plant
BXGF02791 Cephalotaxus fortunei Cephalotaxus fortunei Medicinal Plant
BXGF02979 Panax stipuleanatus Panax stipuleanatus Others
BXGF03069 Quercus canariensis Quercus canariensis Others
BXGF03105 Soulamea pancheri Soulamea pancheri Others
BXGF03139 Pinus longifolia Pinus longifolia Medicinal Plant
BXGF03161 Dendrobium chrysotoxum Dendrobium chrysotoxum Medicinal Plant
BXGF03260 Garcinia xanthochymus Garcinia xanthochymus Medicinal Plant
BXGF03334 Sciadotenia toxifera Sciadotenia toxifera Others
BXGF03518 Mentha cardiaca Mentha cardiaca Others
BXGF03524 Aglaia forbesii Aglaia forbesii Human Edible Plant
BXGF03558 Valeriana microphylla Valeriana microphylla Others
BXGF03569 Hydnocarpus hainanensis Hydnocarpus hainanensis Others
BXGF03637 Rhodiola semenovii Rhodiola semenovii Others
BXGF03866 Toxicodendron succedaneum Toxicodendron succedaneum Medicinal Plant
BXGF04054 Taxodium mucronatum Taxodium mucronatum Medicinal Plant
BXGF04602 Platycladus orientalis Platycladus orientalis Medicinal Plant
BXGF04643 Selaginella pulvinata Selaginella pulvinata Medicinal Plant
BXGF04664 Torreya nucifera Torreya nucifera Medicinal Plant
BXGF05043 mammea siamensis mammea siamensis Medicinal Plant
BXGF05170 Crotalaria candicans Crotalaria candicans Others
BXGF05171 Erucastrum gallicum Erucastrum gallicum Others
BXGF05269 Hypericum perforatum Hypericum perforatum Medicinal Plant
BXGF05385 Eria japonica Eria japonica Others
BXGF05395 Cycas revoluta Cycas revoluta Medicinal Plant
BXGF05427 Salvia sessei Salvia sessei Others
BXGF05466 Juniperus drupacea Juniperus drupacea Medicinal Plant
BXGF05551 Etlingera elatior Etlingera elatior Medicinal Plant
BXGF05615 Ceropegia dichotoma Ceropegia dichotoma Garden Plant
BXGF05708 Ononis spinosa Ononis spinosa Medicinal Plant
BXGF05903 Crinum moorei Crinum moorei Others
BXGF05913 Eucalyptus globulus subsp. bicostata Eucalyptus globulus subsp. bicostata Medicinal Plant
BXGF05980 Podocarpus montanus Podocarpus montanus Medicinal Plant
BXGF06069 Dendrobium loddigesii Dendrobium loddigesii Medicinal Plant
BXGF06119 Gypsophila perfoliata Gypsophila perfoliata Others
BXGF06127 Juniperus occidentalis Juniperus occidentalis Medicinal Plant
BXGF06195 Pterocaulon virgatum Pterocaulon virgatum Medicinal Plant
BXGF06241 Vernonia cistifolia Vernonia cistifolia Others
BXGF06274 Sonneratia caseolaris Sonneratia caseolaris Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease