Showing entry for Spectrin alpha chain, erythrocytic 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005890
Protein NameSpectrin alpha chain, erythrocytic 1
Uniport IdP02549
GeneSPTA1
Gene Id6708
DomainEFhand_Ca_insen; SH3_1; Spectrin
Pfam PF08726   PF00018   PF00435  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051693 actin filament capping
Biological Process GO:0007015 actin filament organization
Biological Process GO:0007411 axon guidance
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0002260 lymphocyte homeostasis
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0007009 plasma membrane organization
Biological Process GO:0006779 porphyrin-containing compound biosynthetic process
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0008360 regulation of cell shape
molecular function GO:0051015 actin filament binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0005200 structural constituent of cytoskeleton
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0030424 axon
cellular component GO:0032437 cuticular plate
cellular component GO:0005829 cytosol
cellular component GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane
cellular component GO:0008091 spectrin
cellular component GO:0014731 spectrin-associated cytoskeleton
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9607240 FLT3 Signaling
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002881 BXGD000140 Anemia, Hemolytic, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007196 BXGD000453 Restrictive cardiomyopathy Cardiovascular Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013902 BXGD000865 Elliptocytosis, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018834 BXGD001238 Heartburn Pathological Conditions, Signs and Symptoms
C0018952 BXGD001257 Extramedullary Hematopoiesis Function
C0019034 BXGD001268 Hemoglobin SC Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022353 BXGD001539 Neonatal Jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0023508 BXGD001675 White Blood Cell Count procedure
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0035435 BXGD002549 Rheumatism Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0037889 BXGD002709 Hereditary spherocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0085593 BXGD003196 Chills Pathological Conditions, Signs and Symptoms
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0200635 BXGD004041 Lymphocyte Count measurement
C0206160 BXGD004166 Reticulocytosis Pathological Conditions, Signs and Symptoms
C0206161 BXGD004167 Reticulocyte count (procedure)
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221409 BXGD004460 Anemia, hereditary spherocytic hemolytic Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0238013 BXGD004855 Invasive aspergillosis Infections
C0272048 BXGD006297 stomatocytic anemia Hemic and Lymphatic Diseases
C0398623 BXGD008202 Thrombophilia Hemic and Lymphatic Diseases
C0423791 BXGD008509 Maculopapular Lesion Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0427480 BXGD008617 Elliptocytosis found
C0456070 BXGD008863 Growth delay
C0474535 BXGD008954 Mean corpuscular hemoglobin concentration determination
C0520739 BXGD009106 Hereditary pyropoikilocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0553681 BXGD009406 Hypofibrinogenemia
C0553720 BXGD009414 Spherocytosis
C0677598 BXGD009719 Stomatocytosis Result
C0857007 BXGD011131 Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1849478 BXGD015056 Increased red cell osmotic fragility
C1851741 BXGD015232 ELLIPTOCYTOSIS 2 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1859778 BXGD015931 Postnatal growth retardation
C2674218 BXGD017240 SPHEROCYTOSIS, TYPE 1 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2678338 BXGD017404 SPHEROCYTOSIS, TYPE 3 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C2931788 BXGD018064 Atypical Hemolytic Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C4025184 BXGD021580 Spontaneous hemolytic crises Hemic and Lymphatic Diseases
C4025285 BXGD021625 Microspherocytosis
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4531297 BXGD023215 Increased mean corpuscular hemoglobin concentration
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein